RLCP 1.12.30000.14 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms

R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.12.-.- : Carboxylic Ester (One of Carbonyl Ester bonds) (Ligand group involved)

C 1.12.30000.- : Trypsin-like mechanism (Nucleophile/Acid-Base/Modulator/Stabilizer); Modulator-assisted base activation of nucleophile; Nucleophilic attack on target bond; SN2-like reaction; covalent bond between enzyme and substrate; followed by protonation to leaving group; hydrolysis by base-activated water (Catalytic mechanism)

P 1.12.30000.14 : Ser/His/Glu + mainchain amide (Residues/cofactors in Protein)


1st Nucleophile : a catalytic residue
Catalytic groups : groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue



Related Enzymes

There are 2 entries in this class.
  • S00057 : 3.1.1.7; Acetylcholinesterase (Catalytic domain; 3.40.50.1820)
  • S00725 : 3.1.1.8; Cholinesterase (Catalytic domain; 3.40.50.1820)