RLCP 1.13.10000.- :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms

R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.13.-.- : Amide bond (One of Carbonyl Ester bonds; including peptide bond) (Ligand group involved)

C 1.13.10000.- : Two zinc beta-lactamase mechanism (Stabilizer); Cofactor-assisted water activation for SN2-like nucleophilic attack; Bond cleavage; cofactor-assisted stabilization of transition state; Water protonation to leaving group (Catalytic mechanism)


1st Nucleophile : water
Catalytic groups : cofactor + groups in residue/substrate
General Base : non-existent
General Acid : non-existent

Residues/Cofactors involved in Proteins

  • 1.13.10000.1220 : Asn + two zinc ions bound to His/Cys/Asp cluster