RLCP 1.13.11110.262 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms

R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.13.-.- : Amide bond (One of Carbonyl Ester bonds; including peptide bond) (Ligand group involved)

C 1.13.11110.- : Carboxypeptidase A-like mechanism (Acid-Base-Stabilizer/Stabilizer); Cofactor-assisted water activated by base; Cofactor-assisted stabilization of transition-state; Protonation to leaving group by acid; SN1/SN2 unclear (Catalytic mechanism)

P 1.13.11110.262 : An acidic residue + Arg + mainchain carbonyl + zinc ion bound to His/Glu cluster (Residues/cofactors in Protein)


1st Nucleophile : water
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There are 4 entries in this class.
  • S00407 : 3.4.17.18; Carboxypeptidase T (Catalytic domain; 3.40.630.10)
  • D00193 : 3.4.17.15; Carboxypeptidase A2 (Catalytic domain; 3.40.630.10)
  • D00467 : 3.4.17.1; Carboxypeptidase A (Catalytic domain; 3.40.630.10)
  • D00512 : 3.4.17.2; Carboxypeptidase B (Catalytic domain; 3.40.630.10)