EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.13.-.- : Amide bond (One of Carbonyl Ester bonds; including peptide bond) (Ligand group involved)

C 1.13.30000.- : Trypsin-like mechanism (Nucleophile/Acid-Base/Modulator/Stabilizer); Modulator-assisted base activation of nucleophile; Nucleophilic attack on target bond; SN2-like reaction; covalent bond between enzyme and substrate; followed by protonation to leaving group; hydrolysis by base-activated water (Catalytic mechanism)

P 1.13.30000.10 : Ser/His/Asp + mainchain amide (Residues/cofactors in Protein)


1st Nucleophile : a catalytic residue
Catalytic groups : groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue



Related Enzymes

There are 44 entries in this class.
  • S00353 : 3.4.11.5; Proline iminopeptidase (Catalytic domain; 3.40.50.1820)
  • S00374 : 3.4.16.6; Serine carboxypeptidase 2 (Catalytic domain; 3.40.50.1820)
  • S00517 : 3.4.16.5; Lysosomal protective protein (Catalytic domain; 3.40.50.1820)
  • D00189 : 3.4.16.5; Carboxypeptidase Y (Catalytic domain; 3.40.50.1820)
  • D00194 : 3.4.21.1; Chymotrypsin-1 (Catalytic domain; 2.40.10.10)
  • D00197 : 3.4.21.4; Trypsin (Catalytic domain; 2.40.10.10)
  • D00211 : 3.4.21.32; Brachyurin (Catalytic domain; 2.40.10.10)
  • D00212 : 3.4.21.35; Glandular kallikrein (Catalytic domain; 2.40.10.10)
  • D00214 : 3.4.21.36; Elastase-1 (Catalytic domain; 2.40.10.10)
  • D00216 : 3.4.21.37; Neutrophil elastase (Catalytic domain; 2.40.10.10)
  • D00224 : 3.4.21.81; Streptogrisin-B (Catalytic domain; 2.40.10.10)
  • D00426 : 3.4.21.20; Cathepsin G (Catalytic domain; 2.40.10.10)
  • D00428 : 3.4.21.39; Chymase (Catalytic domain; 2.40.10.10)
  • D00429 : 3.4.21.46; Complement factor D (Catalytic domain; 2.40.10.10)
  • D00430 : 3.4.21.50; Protease 1 (Catalytic domain; 2.40.10.10)
  • D00431 : 3.4.21.59; Tryptase beta-2 (Catalytic domain; 2.40.10.10)
  • D00432 : 3.4.21.71; Elastase-2A (Catalytic domain; 2.40.10.10)
  • D00433 : 3.4.21.76; Myeloblastin (Catalytic domain; 2.40.10.10)
  • D00434 : 3.4.21.80; Streptogrisin-A (Catalytic domain; 2.40.10.10)
  • D00435 : 3.4.21.82; Glutamyl endopeptidase 2 (Catalytic domain; 2.40.10.10)
  • D00497 : 3.4.21.35; Tonin (Catalytic domain; 2.40.10.10)
  • D00528 : 3.4.21.119; Epidermal growth factor-binding protein type B (Catalytic domain; 2.40.10.10)
  • D00848 : 3.4.21.-; Snake venom serine protease Dav-PA (Catalytic domain; 2.40.10.10)
  • D00850 : 3.4.21.118; Kallikrein-8 (Catalytic domain; 2.40.10.10)
  • D00851 : 3.4.21.19; Glutamyl endopeptidase (Catalytic domain; 2.40.10.10)
  • D00852 : 3.4.21.78; Granzyme A (Catalytic domain; 2.40.10.10)
  • D00855 : 3.4.21.79; Granzyme B (Catalytic domain; 2.40.10.10)
  • T00074 : 3.4.21.5; Prothrombin (Catalytic domain; 2.40.10.10)
  • T00410 : 3.4.21.10; Acrosin (Catalytic domain; 2.40.10.10)
  • T00411 : 3.4.21.108; Serine protease HTRA2 (Catalytic domain; 2.40.10.10)
  • M00122 : 3.4.21.92; ATP-dependent Clp protease proteolytic subunit (Catalytic domain; 3.90.226.10)
  • M00133 : 3.4.21.22; Coagulation factor IX (Catalytic domain; 2.40.10.10)
  • M00139 : 3.4.21.41; Complement C1r subcomponent (Catalytic domain; 2.40.10.10)
  • M00152 : 3.4.21.73; Urokinase-type plasminogen activator (Catalytic domain; 2.40.10.10)
  • M00155 : 3.4.21.68; Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68)AltName: INN=Alteplase;AltName: INN=Reteplase; (Catalytic domain; 2.40.10.10)
  • M00167 : 3.4.21.12; Alpha-lytic protease (Catalytic domain; 2.40.10.10)
  • M00181 : 3.4.21.35; Kallikrein 1-related peptidase b3 (Catalytic domain; 2.40.10.10)
  • M00212 : 3.4.21.69; Vitamin K-dependent protein C (Catalytic domain; 2.40.10.10)
  • M00227 : 3.4.21.9; Enteropeptidase (Catalytic domain; 2.40.10.10)
  • M00315 : 3.4.21.104; Mannan-binding lectin serine protease 2 (Catalytic domain; 2.40.10.10)
  • M00316 : 3.4.21.42; Complement C1s subcomponent (Catalytic domain; 2.40.10.10)
  • M00317 : 3.4.21.47; Complement factor B (Catalytic domain; 2.40.10.10)
  • M00348 : 3.4.21.109; Suppressor of tumorigenicity 14 protein (Catalytic domain; 2.40.10.10)
  • M00349 : 3.4.21.106; Serine protease hepsin (Catalytic domain; 2.40.10.10)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)