RLCP 1.13.30000.44 :EzCatDB EzCatDB

Hierarchic Classification of Catalytic Mechanisms

R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.13.-.- : Amide bond (One of Carbonyl Ester bonds; including peptide bond) (Ligand group involved)

C 1.13.30000.- : Trypsin-like mechanism (Nucleophile/Acid-Base/Modulator/Stabilizer); Modulator-assisted base activation of nucleophile; Nucleophilic attack on target bond; SN2-like reaction; covalent bond between enzyme and substrate; followed by protonation to leaving group; hydrolysis by base-activated water (Catalytic mechanism)

P 1.13.30000.44 : Cys/His/Asn + Gln/mainchain amide (Residues/cofactors in Protein)

1st Nucleophile : a catalytic residue
Catalytic groups : groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There are 9 entries in this class.
  • S00444 :; Cathepsin Z (Catalytic domain;
  • S00445 :; Cathepsin B (Catalytic domain;
  • S00446 :; Chymopapain (Catalytic domain;
  • S00447 :; Actinidain (Actinidin) (EC Allergen=Act c 1; (Catalytic domain;
  • S00448 :; Cathepsin H (Catalytic domain;
  • S00449 :; Papaya proteinase 4 (Catalytic domain;
  • S00450 :; Caricain (Catalytic domain;
  • S00451 :; Cathepsin K (Catalytic domain;
  • S00518 :; Cathepsin L1 (Catalytic domain;