RLCP 1.13.30100.40 :EzCatDB EzCatDB

Hierarchic Classification of Catalytic Mechanisms

R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.13.-.- : Amide bond (One of Carbonyl Ester bonds; including peptide bond) (Ligand group involved)

C 1.13.30100.- : Caspase-1-like mechanism (Nucleophile/Acid-Base/Stabilizer); Base-activation of nucleophile; covalent bond formation between nucleophile and target atom; intermediate stablilized; protonation to 1st leaving group; covalent bond attacked by base-activated water; intermediate stabilized; protonation to nucleophile (Catalytic mechanism)

P 1.13.30100.40 : Cys/His + mainchain amide (Residues/cofactors in Protein)

1st Nucleophile : a catalytic residue
Catalytic groups : groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There is one entry in this class.
  • D00522 :; Caspase-1 (Catalytic domain;