RLCP 1.15.72000.565 :EzCatDB EzCatDB

Hierarchic Classification of Catalytic Mechanisms

R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.15.-.- : Phosphoric Ester (Ligand group involved)

C 1.15.72000.- : Phosphoinositide phospholipase-C-delta-1-like mechanism (Base-Acid/Acid-Base/Stabilizer); Inorganic cofactor-assisted activation of substrate nucleophile by base; Intramolecular covalent bond within substrate induced by substrate-assisted nucleophilic attack & protonation to leaving group by general acid (SN2-like reaction); Inorganic cofactor-assisted stabilization of transition-state; 2nd base-activated water attacks on intermediate; Protonation to 2nd leaving group (1st nucleophile); 2nd leaving group stabilized by inorganic cofactor (Catalytic mechanism)

P 1.15.72000.565 : Glu/His + His/Glu/Asn + calcium ion bound to His/Asn + acidic residues (Residues/cofactors in Protein)

1st Nucleophile : a group in substrate
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There are 2 entries in this class.
  • M00118 :; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 (Catalytic domain;
  • M00183 :; Putative uncharacterized protein (Catalytic domain;