EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.15.-.- : Phosphoric Ester (Ligand group involved)

C 1.15.72000.- : Phosphoinositide phospholipase-C-delta-1-like mechanism (Base-Acid/Acid-Base/Stabilizer); Inorganic cofactor-assisted activation of substrate nucleophile by base; Intramolecular covalent bond within substrate induced by substrate-assisted nucleophilic attack & protonation to leaving group by general acid (SN2-like reaction); Inorganic cofactor-assisted stabilization of transition-state; 2nd base-activated water attacks on intermediate; Protonation to 2nd leaving group (1st nucleophile); 2nd leaving group stabilized by inorganic cofactor (Catalytic mechanism)

P 1.15.72000.565 : Glu/His + His/Glu/Asn + calcium ion bound to His/Asn + acidic residues (Residues/cofactors in Protein)


1st Nucleophile : a group in substrate
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There are 2 entries in this class.
  • M00118 : 3.1.4.11; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Catalytic domain; 3.20.20.190)
  • M00183 : 3.1.4.11; Putative uncharacterized protein (Catalytic domain; 3.20.20.190)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)