RLCP 1.15.8240.1167 :EzCatDB EzCatDB

Hierarchic Classification of Catalytic Mechanisms

R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.15.-.- : Phosphoric Ester (Ligand group involved)

C 1.15.8240.- : Nuclease P1-like mechanism (Base/Stabilizer); Cofactor-assisted water activation by base; Nucleophilic attack by activated water; Cofactor-assisted stabilization of transition-state; rather SN2 reaction (Catalytic mechanism)

P 1.15.8240.1167 : An acidic residue + Arg/Lys + two magnesium ions bound to acidic residues/mainchain carbonyl + another magnesium ion bound to leaving group (Residues/cofactors in Protein)

1st Nucleophile : water
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : non-existent

Related Enzymes

There is one entry in this class.
  • S00920 :; Diadenosine 5'',5''''''-P1,P4-tetraphosphate hydrolase (Catalytic domain;