RLCP 1.30.46030.482 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms

R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.30.-.- : C-O bond (O-glycoside bond) (Ligand group involved)

C 1.30.46030.- : alpha-mannosidase-like mechanism (Nucleophile/Acid-Base/Modulator); Protonation to leaving group by acid leading to inorganic-cofactor stabilized transition-state; Modulator-assisted SN1-like nucleophilic attack forming covalent intermediate; intermediate stabilized by inorganic-cofactor; base-activated water attack on intermediate leading to transition-state stabilized by inorganic cofactor (Catalytic mechanism)

P 1.30.46030.482 : Two acidic residues + Arg/Tyr + zinc ion bound to His/acidic residue + substrate/intermediate (Residues/cofactors in Protein)


1st Nucleophile : a catalytic residue
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There is one entry in this class.
  • M00314 : 3.2.1.24; Alpha-mannosidase (Catalytic domain; 3.20.110.10)