EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.40.-.- : C-N bond (N-glycoside bond) (Ligand group involved)

C 1.40.6430.- : AlkA-DNA-glycosylase-like mechanism (Stabilizer); To-be-hydrolyzed group leads to transition-state; Stabilization of transition-state leads to SN1-like bond cleavage; Leaving group acts as a (substrate-assisted) base to activate water; Water attacks on the transition-state (Catalytic mechanism)

P 1.40.6430.132 : An acidic residue + Tyr/Trp (Residues/cofactors in Protein)


1st Nucleophile : water
Catalytic groups : groups in residue/substrate
General Base : a group in substrate/cofactor
General Acid : non-existent

Related Enzymes

There is one entry in this class.
  • T00070 : 3.2.2.21; DNA-3-methyladenine glycosylase 2 (Catalytic domains; 1.10.340.30, 1.10.1670.10)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)