EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.51.-.- : C-C bond (Ketonic Carbon-Carbon bond; Carbonyl Carbon-Carbon adjacent to sp2 carbon) (Ligand group involved)


Catalytic mechanisms

  • 1.51.790.- : Beta-ketoacyl-ACP synthase II 2nd reaction step-like mechanism (Base/Stabilizer/Modulator); Modulation of nucleophile; Base deprotonation of nucleophile through a proton-shuttle residue; Nucleophilic attacks on transferred group forming an intermediate; Stabilization of intermediate; Acid protonation to leaving group (SN2-like reaction)
  • 1.51.3100.- : C-C hydrolase-like hydrolysis mechanism (Base/Stabilizer/Modulator); Base activation of water; Activated water attacks on scissile bond; Intermediate stabilized; Bond cleavage occurs
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)