EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.100.-.- : Phosphate group from Hydroxyl oxygen to Hydroxyl oxygen (Ligand group involved)

C 3.100.305000.- : DNA topoisomerase II autotransfer mechanism (Nucleophile/Base/Stabilizer); Base activation of nucleophile; Nucleophilic attack on transferred group; Inroganic-cofactor-assisted stabilization of transition-state; followed by nucleophilic attack by acceptor group on transferred group (Catalytic mechanism)

P 3.100.305000.501 : Tyr + Acidic residues + Arg cluster + magnesium ion bound to acidic residues (Residues/cofactors in Protein)


1st Nucleophile : a catalytic residue
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : non-existent

Related Enzymes

There is one entry in this class.
  • M00048 : (reaction 2) 5.99.1.3; DNA topoisomerase 2 (Catalytic domains; 3.30.230.10, 3.30.565.10, 3.40.50.670, 3.90.199.10)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)