RLCP 3.103.106000.1163 :EzCatDB EzCatDB

Hierarchic Classification of Catalytic Mechanisms

R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.103.-.- : Phosphate group from Phosphate oxygen to Hydroxyl oxygen (Ligand group involved)

C 3.103.106000.- : PI3-kinase-p110-like mechanism (Base/Stabilizer); Base activation of acceptor group; Nucleophilic attack on transferred group by acceptor group; Inorganic-cofactor-assisted stabilization of transition-state; Inorganic-cofactor interacting with transferred group and leaving group; SN1/SN2 unclear (Catalytic mechanism)

P 3.103.106000.1163 : Asp/His + Ser/Lys + two magnesium ions bound to Asp/Asn (Residues/cofactors in Protein)

1st Nucleophile : an acceptor group in substrate
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : non-existent

Related Enzymes

There is one entry in this class.
  • M00043 :; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Catalytic domains; 1.10.1070.11, 3.30.1010.10)