EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.103.-.- : Phosphate group from Phosphate oxygen to Hydroxyl oxygen (Ligand group involved)

C 3.103.130000.- : Insulin receptor-like mechanism (Base/Modulator); Inorganic-cofactor-assisted SN1-like transition state between acceptor/transferred/leaving groups; Base deprotonation of acceptor group; Covalent bond formed between acceptor and transferred group; Inorganic-cofactor interacting with transferred/leaving groups (Catalytic mechanism)

P 3.103.130000.1162 : Asp/Arg + two magnesium ions bound to Asp/Asn (Residues/cofactors in Protein)


1st Nucleophile : an acceptor group in substrate
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : non-existent

Related Enzymes

There are 20 entries in this class.
  • M00124 : 2.7.10.1; Ephrin type-B receptor 2 (Catalytic domain; 1.10.510.10)
  • M00127 : 2.7.10.1; Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr)AltName: CD_antigen=CD331; (Catalytic domain; 1.10.510.10)
  • M00129 : 2.7.10.1; Insulin receptor (IR) (EC 2.7.10.1)AltName: CD_antigen=CD220; (Catalytic domain; 1.10.510.10)
  • M00130 : 2.7.10.2; Tyrosine-protein kinase ABL1 (Catalytic domain; 1.10.510.10)
  • M00131 : 2.7.10.1; Vascular endothelial growth factor receptor 1 (Catalytic domain; 1.10.510.10)
  • M00132 : 2.7.10.1; High affinity nerve growth factor receptor (Catalytic domain; 1.10.510.10)
  • M00304 : 2.7.10.2; Tyrosine-protein kinase CSK (Catalytic domain; 1.10.510.10)
  • M00323 : 2.7.10.1; Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog)AltName: CD_antigen=CD117; (Catalytic domain; 1.10.510.10)
  • M00325 : 2.7.10.1; Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK)AltName: CD_antigen=CD202b; (Catalytic domain; 1.10.510.10)
  • M00326 : 2.7.10.1; Proto-oncogene tyrosine-protein kinase receptor Ret (Catalytic domain; 1.10.510.10)
  • M00327 : 2.7.10.1; Muscle (Catalytic domain; 1.10.510.10)
  • M00328 : 2.7.10.1; ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase)AltName: CD_antigen=CD246; (Catalytic domain; 1.10.510.10)
  • M00329 : 2.7.10.1; Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron)AltName: CD_antigen=CD136; (Catalytic domain; 1.10.510.10)
  • M00330 : 2.7.10.1; Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms)AltName: CD_antigen=CD115; (Catalytic domain; 1.10.510.10)
  • M00331 : 2.7.10.1; Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1)AltName: CD_antigen=CD135; (Catalytic domain; 1.10.510.10)
  • M00332 : 2.7.10.1; Tyrosine-protein kinase Mer (Catalytic domain; 1.10.510.10)
  • M00333 : 2.7.10.2; Tyrosine-protein kinase ZAP-70 (Catalytic domain; 1.10.510.10)
  • M00335 : 2.7.10.2, 2.7.11.1; Activated CDC42 kinase 1 (Catalytic domain; 1.10.510.10)
  • M00339 : 2.7.10.2; Tyrosine-protein kinase Fes/Fps (Catalytic domain; 1.10.510.10)
  • M00344 : 2.7.10.2; Cytoplasmic tyrosine-protein kinase BMX (Catalytic domain; 1.10.510.10)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)