RLCP 3.103.70000.350 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms

R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.103.-.- : Phosphate group from Phosphate oxygen to Hydroxyl oxygen (Ligand group involved)

C 3.103.70000.- : Thymidine kinase-like mechanism (Base/Stabilizer); Base activation of acceptor group; nucleophilic attack on transferred group by acceptor group; Inorganic-cofactor-assisted stabilization of transferred group and leaving group; SN2-like direct reacion (Catalytic mechanism)

P 3.103.70000.350 : An acidic residue + Arg/Lys cluster + magnesium ion bound to acidic residue and [Ser or Thr] (Residues/cofactors in Protein)


1st Nucleophile : an acceptor group in substrate
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : non-existent

Related Enzymes

There is one entry in this class.
  • S00302 : 2.7.1.21; Thymidine kinase (Catalytic domain; 3.40.50.300)