RLCP 3.103.90020.- :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms

R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.103.-.- : Phosphate group from Phosphate oxygen to Hydroxyl oxygen (Ligand group involved)

C 3.103.90020.- : DNA polymerase-like mechanism (Stabilizer); Inorganic-cofactor-assisted nucleophilic attack by acceptor group on transferred group; SN2-like direct reaction; Transition state stabilized by cofactor and stabilizer; Inorganic-cofactor interacting with acceptor/transferred/leaving groups (Catalytic mechanism)


1st Nucleophile : an acceptor group in substrate
Catalytic groups : cofactor + groups in residue/substrate
General Base : non-existent
General Acid : non-existent

Residues/Cofactors involved in Proteins

  • 3.103.90020.1131 : Arg/Lys/Asn + two magnesium ions bound to acidic residues
  • 3.103.90020.1134 : Arg/Lys/Asn + two magnesium ions bound to acidic residues/Ser/mainchain carbonyl
  • 3.103.90020.1135 : Arg/Lys/His/Tyr + two magnesium ions bound to acidic residues/mainchain carbonyl
  • 3.103.90020.1136 : Arg/Lys + two magnesium ions bound to acidic residues/mainchain carbonyl
  • 3.103.90020.1140 : Arg/Lys + mainchain amide + magnesium ion bound to Thr + a divalent metal ion bound to His/Asp/Lys
  • 3.103.90020.1141 : Arg/Lys/His + mainchain amide groups + two divalent metal ions bound to acidic residues/mainchain carbonyl