RLCP 3.103.90020.1141 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms

R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.103.-.- : Phosphate group from Phosphate oxygen to Hydroxyl oxygen (Ligand group involved)

C 3.103.90020.- : DNA polymerase-like mechanism (Stabilizer); Inorganic-cofactor-assisted nucleophilic attack by acceptor group on transferred group; SN2-like direct reaction; Transition state stabilized by cofactor and stabilizer; Inorganic-cofactor interacting with acceptor/transferred/leaving groups (Catalytic mechanism)

P 3.103.90020.1141 : Arg/Lys/His + mainchain amide groups + two divalent metal ions bound to acidic residues/mainchain carbonyl (Residues/cofactors in Protein)


1st Nucleophile : an acceptor group in substrate
Catalytic groups : cofactor + groups in residue/substrate
General Base : non-existent
General Acid : non-existent

Related Enzymes

There are 2 entries in this class.
  • M00055 : (reaction 1) 2.7.7.7, 3.1.11.1, 3.1.11.3; DNA polymerase I (Catalytic domains; 1.10.473.10, 3.30.70.370, 3.30.420.10)
  • M00175 : (reaction 1) 2.7.7.7, 3.1.11.3; DNA polymerase I (Catalytic domains; 1.10.473.10, 3.30.70.370, 3.40.50.1010)