EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.113.-.- : Phosphate group from Phosphate oxygen to Carboxyl oxygen (Ligand group involved)

C 3.113.310400.- : Succinyl-CoA synthetase phosphoryl transfer mechanism (Nucleophile/Modulator/Stabilizer); Modulator-assisted nucleophilic attack on transferred group; Inorganic-cofactor-assisted stabilization of transition-state; Covalent-bonded intermediate formation; 2nd nucleophilic attack by acceptor group on intermediate; SN2-like reactions (Catalytic mechanism)

P 3.113.310400.385 : His/Acidic residue + Arg/Thr + mainchain amide + magnesium bound to acidic residue/Asn or Gln (Residues/cofactors in Protein)


1st Nucleophile : a catalytic residue
Catalytic groups : cofactor + groups in residue/substrate
General Base : non-existent
General Acid : non-existent

Related Enzymes

There is one entry in this class.
  • M00035 : (reaction 1) 6.2.1.4; Succinyl-CoA ligase [GDP-forming] subunit alpha (Catalytic domains; 3.30.470.20, 3.30.1490.20, 3.40.50.261)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)