RLCP 3.1143.80000.1190 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms

R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.1143.-.- : Acyl group from Phosphate oxygen to Amine nitrogen (sp3) (Ligand group involved)

C 3.1143.80000.- : Folylpolyglutamate synthase acyl transfer mechanism (Base); Substrate-assisted base activation of acceptor group; Inorganic-cofactor-assisted nucleophilic attack by acceptor group on transferred group; Inorganic-cofactor-assisted stabilization of transition-state; SN2-like direct reaction; Base deprotonation of acceptor group facilitates release of leaving group; Inorganic-cofactor interacting with transferred/leaving groups (Catalytic mechanism)

P 3.1143.80000.1190 : His + two magnesium ions bound (Residues/cofactors in Protein)


1st Nucleophile : an acceptor group in substrate
Catalytic groups : cofactor + groups in residue/substrate
General Base : a group in substrate/cofactor
General Acid : non-existent

Related Enzymes

There are 2 entries in this class.
  • T00109 : (reaction 2) 6.3.2.9; UDP-N-acetylmuramoylalanine--D-glutamate ligase (Catalytic domain; 3.40.1190.10)
  • D00516 : (reaction 2) 6.3.2.17; Folylpolyglutamate synthase (Catalytic domain; 3.40.1190.10)