EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.1143.-.- : Acyl group from Phosphate oxygen to Amine nitrogen (sp3) (Ligand group involved)


Catalytic mechanisms

  • 3.1143.50000.- : Aspartate--ammonia ligase acyl transfer mechanism (Base-Stabilizer/Stabilizer); SN1-like reaction; Nucleophilic attack on transferred group by acceptor group; Stabilization of transferred group and acceptor group in SN1-like transition state; Base-deprotonation of acceptor group in transition-state
  • 3.1143.70030.- : NH(3)-dependent NAD+ synthetase acyl transfer mechanism (Base-Stabilizer); Base activates acceptor group; nucleophilic attack on transferred group by acceptor group; Inorganic-cofactor-assisted stabilization of transferred group and leaving group; SN2-like direct reacion
  • 3.1143.80000.- : Folylpolyglutamate synthase acyl transfer mechanism (Base); Substrate-assisted base activation of acceptor group; Inorganic-cofactor-assisted nucleophilic attack by acceptor group on transferred group; Inorganic-cofactor-assisted stabilization of transition-state; SN2-like direct reaction; Base deprotonation of acceptor group facilitates release of leaving group; Inorganic-cofactor interacting with transferred/leaving groups
  • 3.1143.90000.- : Gro-PCT-like mechanism (Stabilizer); Inorganic-cofactor-assisted nucleophilic attack by acceptor group on transferred group; SN2-like direct reaction; Transition state stabilized by cofactor and stabilizer; Inorganic-cofactor interacting with leaving group
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)