EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.1144.-.- : Acyl group from Amine nitrogen (sp3) to Amine nitrogen (sp3) (Ligand group involved)


Catalytic mechanisms

  • 3.1144.1800.- : Methionyl-tRNA formyltransferase-like mechanism (Acid-Base/Stabilizer/Modulator); Modulator-assisted acid protonation to transferred group to facilitate nucleophilic attack of acceptor group on transferred group; SN2-like reaction; Transition-states stabilized; Modulator/water-assisted proton shuttle from acceptor group to leaving group & Modulator-assisted base deprotonation of transferred group
  • 3.1144.220195.- : Cofactor-dependent-phosphoglycerate-mutase-like mechanism (Nucleophile/Acid-Base/Modulator-Stabilizer/Stabilizer); Modulator-assisted activation of nucleophile; Nucleophilic attack on transferred group; SN2-like reaction; Stabilization of transition-state; covalent intermediate formed; followed by acid protonation to leaving group; Base activation of acceptor group; Nucleophilic attack of acceptor group on transferred group; SN2-like reaction
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)