EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.1147.-.- : Acyl group from Sulfur atom to Amine nitrogen (sp3) (Ligand group involved)


Catalytic mechanisms

  • 3.1147.900.- : Serotonin N-acetyltransferase-like mechanism (Acid/Base/Proton_shuttle/Stabilizer); Base-activation of acceptor group through proton_shuttle and water; SN2-like nucleophilic attack on transferred group by acceptor group; Transition state stabilized; Acid protonation to leaving group
  • 3.1147.6000.- : Histone acetyltransferase type B-like mechanism (Base/Modulator/Stabilizer); Base activation of acceptor group through water; SN2-like nucleophilic attack on transferred group by acceptor group; intermediate stabilized; Release of leaving group
  • 3.1147.6010.- : Glucosamine-1-phosphate N-acetyltransferase-like mechanism (Base/Modulator/Stabilizer); Base activation of acceptor group; SN2-like nucleophilic attack on transferred group by acceptor group; intermediate stabilized; Release of leaving group
  • 3.1147.37500.- : Histone acetyltransferase HPA2-like mechanism (Acid/Stabilizer/Modulator); Modulator-assisted deprotonation of acceptor group; Nucleophilic attack on transferred group by activated acceptor group; Intermediate stabilized; Acid Protonation to leaving group
  • 3.1147.47600.- : NMT-like mechanism (Base/Modulator-Stabilizer/Stabilizer); Modulator-assisted base activation of acceptor group & Another modulator-assisted activation of transferred group; Activated acceptor group stabilized; Activated acceptor group attacks on transferred group leading to transition-state formation; Transition-state stabilization; Substrate-assisted acid protonation to leaving group
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)