EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.1177.-.- : Acyl group from Sulfur atom to Sulfur atom (Ligand group involved)

C 3.1177.220080.- : Beta-ketoacyl-ACP synthase III 1st reaction step-like mechanism (Nucleophile/Base/Proton_shuttle/Modulator-Acid/Modulator/Stabilizer); Modulation of nucleophile; Base deprotonation of nucleophile through a proton-shuttle residue; Nucleophilic attacks on transferred group forming an intermediate; Stabilization of intermediate; Acid protonation to leaving group (SN2-like reaction) (Catalytic mechanism)

P 3.1177.220080.38 : Cys + an acidic residue + [Ser or Thr] + His/Asn + mainchain amide groups (Residues/cofactors in Protein)


1st Nucleophile : a catalytic residue
Catalytic groups : groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There are 3 entries in this class.
  • D00825 : (reaction 1) 2.3.1.180; 3-oxoacyl-[acyl-carrier-protein] synthase 3 (Catalytic domain; 3.40.47.10)
  • D00826 : (reaction 1) 2.3.1.180; 3-oxoacyl-[acyl-carrier-protein] synthase 3 (Catalytic domain; 3.40.47.10)
  • D00867 : (reaction 1) 2.3.1.180; 3-oxoacyl-[acyl-carrier-protein] synthase 3 (Catalytic domain; 3.40.47.10)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)