EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 4.-.-.- : Addition to double-bond (new bond formation and decreased bond-order) (Reaction)

L 4.1244.-.- : Nitrogen atom in aromatic ring (sp2 nitrogen group) to Carbon (sp2) adjacent to double-bond; Opposition to non-beta-elimination (Ligand group involved)

C 4.1244.165000.- : Modulator/Stabilizer; Stabilization of protonation site of unsaturated group & Modulation of addition site of unsaturated group and substrate-assisted acid; Inorganic-cofactor-asisted stabilization of substrate-assisted acid; Added group attacks on unsaturated group & Substrate-assisted acid protonation to protonation site of unsaturated group (Catalytic mechanism)

P 4.1244.165000.313 : Ser/Gln + magnesium ion bound to acidic residues/phosphate (Residues/cofactors in Protein)


1st Nucleophile : Added group (substrate or water)
Catalytic groups : groups in residue/substrate
General Base : non-existent
General Acid : a group in substrate/cofactor

Related Enzymes

There is one entry in this class.
  • S00220 : (reaction 2) 2.5.1.3; Thiamine-phosphate pyrophosphorylase (Catalytic domain; 3.20.20.70)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)