EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 4.-.-.- : Addition to double-bond (new bond formation and decreased bond-order) (Reaction)

L 4.15.-.- : Water (H2O; hydration) to CO2 [leading to hydorxyl group & carboxylate; fixation of CO2] (Ligand group involved)

C 4.15.1107000.- : Base-stabilizer/Proton-shuttle/Stabilizer; Inorganic-cofactor-assisted base deprotonation of added group through proton shuttle; Addition-site of unsaturated group stabilized; Activated added group attacks on the addition-site (Catalytic mechanism)

P 4.15.1107000.480 : Two acidic residues + Arg/Gln/Asn + zinc ion bound to His cluster (Residues/cofactors in Protein)


1st Nucleophile : Added group (substrate or water)
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : non-existent

Related Enzymes

There is one entry in this class.
  • S00167 : 4.2.1.1; Carbonic anhydrase (Catalytic domain; 2.160.10.10)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)