RLCP 5.10.68000.77 :EzCatDB EzCatDB

Hierarchic Classification of Catalytic Mechanisms

R 5.-.-.- : Eliminative double-bond formation (bond cleavage and increased bond-order) (Reaction)

L 5.10.-.- : Hydroxyl group (dehydration) from Carbon (sp3) (Ligand group involved)

C 5.10.68000.- : Base-Acid/Stabilizer/Modulators; Base deprotonates deprotonation site; Intermediate formation stabilized; Modulator-activated water protonates leaving group (non-deprotonation/elimination site) & Acid protonation to eliminated group leading to bond cleavage; Water deprotonates leaving group (non-deprotonation/elimination site) ; E1cb-like reaction (Catalytic mechanism)

P 5.10.68000.77 : His + His+ Asp + Tyr cluster (Residues/cofactors in Protein)

1st Nucleophile : non-existent
Catalytic groups : groups in residue/substrate
General Base : a catalytic residue
General Acid : a group in substrate/cofactor

Related Enzymes

There is one entry in this class.
  • S00176 : (reaction 1); Scytalone dehydratase (Catalytic domain; 3.10.450.50)