EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 5.-.-.- : Eliminative double-bond formation (bond cleavage and increased bond-order) (Reaction)

L 5.10.-.- : Hydroxyl group (dehydration) from Carbon (sp3) (Ligand group involved)

C 5.10.68000.- : Base-Acid/Stabilizer/Modulators; Base deprotonates deprotonation site; Intermediate formation stabilized; Modulator-activated water protonates leaving group (non-deprotonation/elimination site) & Acid protonation to eliminated group leading to bond cleavage; Water deprotonates leaving group (non-deprotonation/elimination site) ; E1cb-like reaction (Catalytic mechanism)

P 5.10.68000.77 : His + His+ Asp + Tyr cluster (Residues/cofactors in Protein)


1st Nucleophile : non-existent
Catalytic groups : groups in residue/substrate
General Base : a catalytic residue
General Acid : a group in substrate/cofactor

Related Enzymes

There is one entry in this class.
  • S00176 : (reaction 1) 4.2.1.94; Scytalone dehydratase (Catalytic domain; 3.10.450.50)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)