RLCP 5.14.3200000.372 :EzCatDB EzCatDB

Hierarchic Classification of Catalytic Mechanisms

R 5.-.-.- : Eliminative double-bond formation (bond cleavage and increased bond-order) (Reaction)

L 5.14.-.- : Hydroxyl group (dehydration) from Carbon (sp3) adjacent to double-bond (Ligand group involved)

C 5.14.3200000.- : Acid/Stabilizer; Acid protonation to eliminated group leading to bond cleavage; Inorganic cofactor-assisted stabilization of intermediate; Inorganic cofactor contribution to leaving group (non-deprotonation/elimination site); E1-like reaction (Catalytic mechanism)

P 5.14.3200000.372 : His + Tyr/Lys/Asn + magnesium ion bound to Asp/Glu/Asn (Residues/cofactors in Protein)

1st Nucleophile : non-existent
Catalytic groups : cofactor + groups in residue/substrate
General Base : non-existent
General Acid : a catalytic residue

Related Enzymes

There is one entry in this class.
  • D00261 : (reaction 2); Glucarate dehydratase (Catalytic domain;