EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 5.-.-.- : Eliminative double-bond formation (bond cleavage and increased bond-order) (Reaction)

L 5.14.-.- : Hydroxyl group (dehydration) from Carbon (sp3) adjacent to double-bond (Ligand group involved)

C 5.14.411700.- : GDP mannose dehydratase 3rd reaction step-like mechanism (Acid); Substrate-assisted modulation of acid; Acid protonation to eliminated group leading to bond cleavage; E1cb-like reaction (Catalytic mechanism)

P 5.14.411700.1 : An acidic residue (Residues/cofactors in Protein)


1st Nucleophile : non-existent
Catalytic groups : groups in residue/substrate
General Base : non-existent
General Acid : a catalytic residue

Related Enzymes

There are 2 entries in this class.
  • D00513 : (reaction 3) 4.2.1.47; GDP-mannose 4,6 dehydratase 2 (Catalytic domains; 3.40.50.720, 3.90.25.10)
  • D00543 : (reaction 3) 4.2.1.47; GDP-mannose 4,6-dehydratase (Catalytic domains; 3.40.50.720, 3.90.25.10)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)