RLCP 5.305.2200100.675 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms

R 5.-.-.- : Eliminative double-bond formation (bond cleavage and increased bond-order) (Reaction)

L 5.305.-.- : Phosphate group from Carboxylate (sp2) [release of CO2] (Ligand group involved)

C 5.305.2200100.- : Base-Acid/Stabilizer; Base deprotonation of deprotonation site of leaving group; Bond cleavage of eliminated group and double-bond formation by E2-like reaction; Inorganic-cofactor-assisted stabilization of eliminated intermediate: Acid protonation to eliminated intermediate (Catalytic mechanism)

P 5.305.2200100.675 : His/Arg + hydrophobic residues + divalent metal ion bound to acidic residues (Residues/cofactors in Protein)


1st Nucleophile : non-existent
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There is one entry in this class.
  • T00217 : (reaction 2) 4.1.1.31; Phosphoenolpyruvate carboxylase (Catalytic domains; 1.20.1100.10, 3.20.20.60)