EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 5.-.-.- : Eliminative double-bond formation (bond cleavage and increased bond-order) (Reaction)

L 5.501.-.- : Sulfide from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] (Ligand group involved)

C 5.501.400060.- : HMG-CoA reductase class II 2nd reaction step-like mechanism (Acid/Stabilizer/Modulator); Modulator-assisted stabilization of deprotonation site of leaving group; Acid protonation to elimination site of eliminated group; E1cB-like reaction (Catalytic mechanism)

P 5.501.400060.67 : His/Lys + two acidic residues (Residues/cofactors in Protein)


1st Nucleophile : non-existent
Catalytic groups : groups in residue/substrate
General Base : non-existent
General Acid : a catalytic residue

Related Enzymes

There are 2 entries in this class.
  • D00607 : (reaction 2) 1.1.1.88; 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Catalytic domain; 3.90.770.10)
  • M00180 : (reaction 2) 1.1.1.34; 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Catalytic domains; 3.30.70.420, 3.90.770.10)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)