EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 6.-.-.- : Exchange of double-bonded atoms (Schiff-base related reaction) (Reaction)

L 6.10.-.- : Carbonyl oxygen to Schiff-base nitrogen (Schiff-base formation; dehydration) (Ligand group involved)

C 6.10.82600.- : Acid-Base-Acid/Modulator; Substituted group attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; Base deprotonation of substituted group; Lone pair on nucleophile attacks again on double-bond partner atom & 2nd Acid protonation to leaving group; Organic-cofactor-assisted reaction (Catalytic mechanism)

P 6.10.82600.5900 : Lys/Tyr + PMP bound (Residues/cofactors in Protein)


1st Nucleophile : Substituted group (substrate or water)
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There are 3 entries in this class.
  • D00101 : (reaction 4) 2.6.1.1; Aspartate aminotransferase (Catalytic domain; 3.40.640.10)
  • D00102 : (reaction 4) 2.6.1.5; Tyrosine aminotransferase (Catalytic domain; 3.40.640.10)
  • D00108 : (reaction 4) 2.6.1.57; Aromatic-amino-acid aminotransferase (Catalytic domain; 3.40.640.10)
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)