RLCP 6.30.115020.- :EzCatDB EzCatDB

Hierarchic Classification of Catalytic Mechanisms

R 6.-.-.- : Exchange of double-bonded atoms (Schiff-base related reaction) (Reaction)

L 6.30.-.- : Exchange of Schiff-base nitrogen atoms (external aldimine formation) (Ligand group involved)

C 6.30.115020.- : Modulator; Oraganic-cofactor/substrate-assisted activation of substituted group; Activated substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Cofactor-assisted activation of nucleophile; Lone pair on nucleophile attacks again on doulbe-bond partner atom (Catalytic mechanism)

1st Nucleophile : Substituted group (substrate or water)
Catalytic groups : cofactor + groups in residue/substrate
General Base : a group in substrate/cofactor
General Acid : a group in substrate/cofactor

Residues/Cofactors involved in Proteins

  • 6.30.115020.5300 : Tyr + PLP double-bonded to Lys