RLCP 6.40.477300.5510 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms

R 6.-.-.- : Exchange of double-bonded atoms (Schiff-base related reaction) (Reaction)

L 6.40.-.- : Exchange of Schiff-base nitrogen atoms (internal aldimine formation) (Ligand group involved)

C 6.40.477300.- : Nucleophile/Base-Acid-Base; Base-activated nucleophile attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; 2nd base deprotonation of nucleophile; Lone pair on nucleophile attacks again on double-bond partner atom; Organic-cofactor-assisted reaction (Catalytic mechanism)

P 6.40.477300.5510 : Lys/His + PLP double-bonded to substrate/intermediate (Residues/cofactors in Protein)


1st Nucleophile : a catalytic residue
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There is one entry in this class.
  • T00089 : (reaction 7) 4.2.1.20; Tryptophan synthase alpha chain (Catalytic domains; 3.20.20.70, 3.40.50.1100)