EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 8.-.-.- : Isomerization (shift of double-bond position) (Reaction)

L 8.311.-.- : Adjacent bond; C=N-C to C-N=C (Ligand group involved)

C 8.311.591510.- : Base-Acid/Modulator; Organic-cofactor-bound to central atom; Modulator-assisted stabilization of organic cofactor; Base deprotonation of initially single-bonded atom leading to intermediate; Acid protonation to initially double-bonded atom (Catalytic mechanism)


1st Nucleophile : non-existent
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Residues/Cofactors involved in Proteins

  • 8.311.591510.5526 : Lys + acidic residue + Tyr + PLP double-bonded to substrate/intermediate
  • 8.311.591510.5527 : Lys + acidic residue + Tyr + PLP covalently bound to substrate/intermediate
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Corporation (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Corporation (JST) (September 2005 - September 2010)
    Funded by BIRD/Japan Science and Technology Corporation (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)

    © Computational Biology Research Center, AIST, 2004 All Rights Reserved.