EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 9.-.-.- : Hydride transfer (Reaction)

L 9.5010.-.- : From nicotinamide (NADH/NADPH) to C=O (Ligand group involved)


Catalytic mechanisms

  • 9.5010.194230.- : 6-phospho-alpha-glucosidase 6th reaction step-like mechanism; Inorganic cofactor-assisted protonation of adjacent atom to hydride acceptor; Hydride transfer
  • 9.5010.536000.- : HMG-CoA reductase class II 3rd reaction step-like mechanism (Acid/Stabilizer/Modulator); Modulator-assisted protonation of adjacent atom to hydride acceptor; Hydride transfer
  • 9.5010.536170.- : Shikimate dehydrogenase-like reduction mechanism (Acid/Modulator); Proton-shuttle-like modulation for acid; Modulator-assisted acid protonation of adjacent atom to hydride acceptor; Hydride transfer
  • 9.5010.536180.- : Ketopantoate reductase-like reduction mechanism (Acid/Modulator); Modulation of acid & NAD(P)-ribose & substrate; Modulator-assisted acid protonation of adjacent atom to hydride acceptor; Hydride transfer
  • 9.5010.536200.- : dTDP dehydrorhamnose reductase-like mechanism (Acid/Modulator); Modulation of adjacent atom to hydride acceptor; Modulator/NAD-assisted acid protonation of adjacent atom to hydride acceptor; Hydride transfer
  • 9.5010.536210.- : GDP mannose dehydratase-final reaction step-like mechanism (Acid/Modulator); Modulator/NAD-assisted acid protonation of adjacent atom through modulator (proton shuttle) to hydride acceptor; Hydride transfer
  • 9.5010.584100.- : HMG-CoA reductase class II 1st reaction step-like mechanism (Stabilizer/Modulator); Modulator-assisted stabilization of adjacent atom to hydride acceptor; Hydride transfer
  • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)