DB code: D00093

CATH domain 3.30.70.520 : Alpha-Beta Plaits
3.30.70.550 : Alpha-Beta Plaits
E.C. 2.3.1.101
CSA
M-CSA
MACiE

CATH domain Related DB codes (homologues)

Uniprot Enzyme Name
UniprotKB Protein name Synonyms RefSeq Pfam
Q49610 Formylmethanofuran--tetrahydromethanopterin formyltransferase
EC 2.3.1.101
H4MPT formyltransferase
NP_613403.1 (Protein)
NC_003551.1 (DNA/RNA sequence)
PF01913 (FTR)
PF02741 (FTR_C)
[Graphical View]

KEGG enzyme name
formylmethanofuran---tetrahydromethanopterin N-formyltransferase
formylmethanofuran-tetrahydromethanopterin formyltransferase
formylmethanofuran:tetrahydromethanopterin formyltransferase
N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT)formyltransferase
FTR
formylmethanofuran:5,6,7,8-tetrahydromethanopterinN5-formyltransferase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
Q49610 FTR_METKA Formylmethanofuran + 5,6,7,8- tetrahydromethanopterin = methanofuran + 5-formyl-5,6,7,8- tetrahydromethanopterin. Homotetramer composed of two dimers. Dimerization is sufficient for enzyme activity, but tetramerization is required for high thermostability. Cytoplasm.

KEGG Pathways
Map code Pathways E.C.
MAP00680 Methane metabolism
MAP00790 Folate biosynthesis

Compound table
Substrates Products Intermediates
KEGG-id C01001 C01217 C00862 C01274
E.C.
Compound Formylmethanofuran 5,6,7,8-Tetrahydromethanopterin Methanofuran N5-Formyl-5,6,7,8-tetrahydromethanopterin
Type amide group,aromatic ring (only carbon atom),carbohydrate,carboxyl group,aromatic ring (with hetero atoms other than nitrogen atoms),peptide/protein amide group,amine group,aromatic ring (only carbon atom),aromatic ring (with nitrogen atoms),carbohydrate,carboxyl group,phosphate group/phosphate ion amine group,aromatic ring (only carbon atom),carbohydrate,carboxyl group,aromatic ring (with hetero atoms other than nitrogen atoms),peptide/protein amide group,amine group,aromatic ring (only carbon atom),aromatic ring (with nitrogen atoms),carbohydrate,carboxyl group,phosphate group/phosphate ion
ChEBI 17321
PubChem 21122662
5462234
21122601
5462235
1ftrA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1ftrB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1ftrC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1ftrD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1ftrA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1ftrB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1ftrC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1ftrD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1ftrA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1ftrB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1ftrC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1ftrD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1ftrA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1ftrB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1ftrC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1ftrD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain

References for Catalytic Mechanism
References Sections No. of steps in catalysis

References
[1]
Resource
Comments
Medline ID
PubMed ID 8880936
Journal Proteins
Year 1996
Volume 26
Pages 118-20
Authors Shima S, Thauer RK, Michel H, Ermler U
Title Crystallization and preliminary X-ray diffraction studies of formylmethanofuran: tetrahydromethanopterin formyltransferase from Methanopyrus kandleri.
Related PDB
Related UniProtKB
[2]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS)
Medline ID 97341227
PubMed ID 9195883
Journal Structure
Year 1997
Volume 5
Pages 635-46
Authors Ermler U, Merckel M, Thauer R, Shima S
Title Formylmethanofuran: tetrahydromethanopterin formyltransferase from Methanopyrus kandleri - new insights into salt-dependence and thermostability.
Related PDB 1ftr
Related UniProtKB Q49610
[3]
Resource
Comments
Medline ID
PubMed ID 11532013
Journal Eur J Biochem
Year 2001
Volume 268
Pages 4769-75
Authors Pomper BK, Vorholt JA
Title Characterization of the formyltransferase from Methylobacterium extorquens AM1.
Related PDB
Related UniProtKB

Comments

Created Updated
2004-03-17 2009-02-26