DB code: D00214

RLCP classification 1.13.30000.10 : Hydrolysis
CATH domain 2.40.10.10 : Thrombin, subunit H Catalytic domain
2.40.10.10 : Thrombin, subunit H Catalytic domain
E.C. 3.4.21.36
CSA
M-CSA
MACiE

CATH domain Related DB codes (homologues)
2.40.10.10 : Thrombin, subunit H M00139 M00167 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00197 D00211 D00212 D00216 M00212 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00317 M00348 M00349 T00074 T00410 T00411

Uniprot Enzyme Name
UniprotKB Protein name Synonyms MEROPS Pfam RefSeq
Q7SIG3 Elastase-1
EC 3.4.21.36
S01.153 (Serine)
PF00089 (Trypsin)
[Graphical View]
P00772 Elastase-1
EC 3.4.21.36
S01.153 (Serine)
PF00089 (Trypsin)
[Graphical View]
NP_998988.1 (Protein)
NM_213823.1 (DNA/RNA sequence)

KEGG enzyme name
pancreatic elastase
pancreatopeptidase E
pancreatic elastase I
elastase
elaszym
serine elastase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
Q7SIG3 ELA1_SALSA Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa. Secreted. Binds 1 calcium ion per subunit.
P00772 ELA1_PIG Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa. Secreted. Binds 1 calcium ion per subunit.

KEGG Pathways
Map code Pathways E.C.

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00076 C00017 C00012 C00373 C00001 C00098 C00017 C00012 I00087 I00085 I00086
E.C.
Compound Calcium Protein Peptide Elastin H2O Oligopeptide Protein Peptide Peptidyl-tetrahedral intermediate Acyl-enzyme Tetrahedral intermediate
Type divalent metal (Ca2+, Mg2+) peptide/protein peptide/protein peptide/protein H2O amine group,carboxyl group,peptide/protein peptide/protein peptide/protein
ChEBI 29108
15377
PubChem 271
439221
22247451
962
1eltA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1b0eA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:SEI Unbound Unbound
1bmaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:TFA-LEU-MBH-ISO (chain B) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1btuA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:2BL Unbound
1c1mA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1e34B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:TPX Unbound
1e35B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:TPX Unbound
1e36B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:TPY Unbound
1e37B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:TPY Unbound
1e38B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:TPY Unbound
1eaiA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:LEU_31-MET_32 (chain C) Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1eaiB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:LEU_31-MET_32 (chain D) Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1easA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:TFK Unbound Unbound
1eatA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:TFI Unbound Unbound
1eauA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:BDK Unbound Unbound
1elaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:TFA-LYS-PRO-ISO (chain B) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1elbA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:TFA-LYS-LEU-ISO (chain B) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1elcA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:TFA-LYS-PHE-ISO (chain B) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1eldE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:TFA-PHE-ALA-ANI (chain I) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1eleE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:TFA-VAL-ALA-ANI (chain I) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1elfA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:BAF Unbound
1elgA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:BAA Unbound
1esaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1esbA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1estA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:TOS
1fleE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:ALA_24-MET_25 (chain I) Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fzzA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:681 Unbound Unbound
1gvkB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:ACE-ASN-PRO-ILE (chain A) Unbound
1gwaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1h9lB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:VAL-GLU-PRO-ILE (chain A) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1haxB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-bound:VAL-GLU-PRO-ILE (chain A) Unbound
1hayB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1hazB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-bound:VAL-GLU-PRO-ILE (chain A)
1hb0B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1hv7A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:616 Unbound
1incA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:ICL Unbound
1jimA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:ICU Unbound
1l0zA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1l1gA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lkaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Analogue:ACT Unbound Unbound Unbound Unbound Unbound
1lkbA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lvyA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mcvA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mmjN01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:FR1 Unbound Unbound
1nesE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Bound:ACE-ALA-PRO-ALA (chain J) Unbound Analogue:ACE-ALA-PRO-ALA (chain I) Unbound Unbound Unbound
1okxA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:1BO-ALA-THR-THR-LEU-SUJ-CNT-VAL (chain C) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1okxB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:1BO-ALA-THR-THR-LEU-SUJ-CNT-VAL (chain D) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qgfA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:TPX Unbound
1qixB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-bound:VAL-GLU-PRO-ILE (chain A) Unbound
1qnjA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qr3E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:AIB-ORN-THR-ABA-AA4-PHE-AA6-VAL (chain I) Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1uo6A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1uvoA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Analogue:ACT Unbound Unbound Unbound Unbound Unbound
1uvpA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Analogue:ACT Unbound Unbound Unbound Unbound Unbound
2estE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:TFA-LYS-ALA-ANI (chain I) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3estA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
4estE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ACE-ALA-PRO-VAL-FPA (chain I) Unbound Unbound
5estE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHQ-ALA-B2I (chain I) Unbound
6estA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
7estE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:TFA-LEU-ALA-ANI (chain I) Unbound Unbound Unbound Unbound Unbound Unbound Unbound
8estE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:GIS Unbound
9estA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:IBR Unbound
1eltA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1b0eA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1bmaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1btuA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c1mA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1e34B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1e35B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1e36B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1e37B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1e38B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1eaiA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1eaiB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1easA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1eatA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1eauA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1elaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1elbA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1elcA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1eldE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1eleE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1elfA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1elgA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1esaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1esbA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1estA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fleE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fzzA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gvkB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gwaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1h9lB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1haxB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1hayB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1hazB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1hb0B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1hv7A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1incA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jimA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1l0zA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1l1gA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lkaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lkbA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lvyA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mcvA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mmjN02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1nesE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1okxA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1okxB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qgfA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qixB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qnjA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qr3E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1uo6A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1uvoA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CD Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1uvpA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CD Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2estE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3estA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
4estE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
5estE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
6estA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
7estE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
8estE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
9estA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
Swiss-prot;P00772 & PDB;1bma

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1eltA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1b0eA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1bmaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1btuA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1c1mA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1e34B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1e35B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1e36B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1e37B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1e38B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1eaiA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1eaiB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1easA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1eatA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1eauA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1elaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1elbA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1elcA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1eldE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1eleE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1elfA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1elgA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1esaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1esbA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1estA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1fleE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1fzzA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1gvkB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1gwaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1h9lB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1haxB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1hayB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1hazB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1hb0B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1hv7A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1incA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1jimA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1l0zA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 188 GLY 186;SER 188
1l1gA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 188 GLY 186;SER 188
1lkaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 188 GLY 186;SER 188
1lkbA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 188 GLY 186;SER 188
1lvyA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1mcvA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1mmjN01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 188 GLY 186;SER 188
1nesE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1okxA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1okxB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 203 GLY 201;SER 203
1qgfA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1qixB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1qnjA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1qr3E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1uo6A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 188 GLY 186;SER 188
1uvoA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 188 GLY 186;SER 188
1uvpA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 188 GLY 186;SER 188
2estE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
3estA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
4estE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
5estE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
6estA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
7estE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
8estE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
9estA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1eltA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;THR 75;GLU 77;GLU 80(Calcium binding)
1b0eA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1bmaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1btuA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1c1mA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding)
1e34B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1e35B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1e36B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1e37B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1e38B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1eaiA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding)
1eaiB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding)
1easA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1eatA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1eauA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1elaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1elbA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1elcA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1eldE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1eleE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1elfA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1elgA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1esaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1esbA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1estA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1fleE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1fzzA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding)
1gvkB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1gwaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding)
1h9lB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1haxB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1hayB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1hazB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1hb0B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1hv7A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASP 81;GLU 84(Calcium binding)
1incA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1jimA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1l0zA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 45;ASP 93 GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding)
1l1gA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 45;ASP 93 GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding)
1lkaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 45;ASP 93 GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding)
1lkbA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 45;ASP 93 GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding)
1lvyA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1mcvA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding)
1mmjN02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 45;ASP 93 GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding)
1nesE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1okxA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1okxB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 60;ASP 108 GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding)
1qgfA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1qixB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1qnjA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding)
1qr3E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
1uo6A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 45;ASP 93 GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding)
1uvoA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 45;ASP 93 GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding)
1uvpA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 45;ASP 93 GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding)
2estE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
3estA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
4estE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
5estE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
6estA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
7estE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
8estE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)
9estA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102 GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding)

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[7]
Fig.2
[10]
p.1958
[26]
Scheme 1, p.7755
[30]
Fig.3
[33]
Fig.7
[37]
Fig.1
[38]
Scheme 2
[42]
Scheme 2
[43]
Fig.1
[50]
Fig.1

References
[1]
Resource
Comments X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS), AND ACTIVE SITE
Medline ID
PubMed ID 5415110
Journal Nature
Year 1970
Volume 225
Pages 811-6
Authors Shotton DM, Watson HC
Title Three-dimensional structure of tosyl-elastase.
Related PDB
Related UniProtKB P00772
[2]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
Medline ID
PubMed ID 628010
Journal J Mol Biol
Year 1978
Volume 118
Pages 137-208
Authors Sawyer L, Shotton DM, Campbell JW, Wendell PL, Muirhead H, Watson HC
Title The atomic structure of crystalline porcine pancreatic elastase at 2.5 A resolution: comparisons with the structure of alpha-chymotrypsin.
Related PDB 1est
Related UniProtKB P00772
[3]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 6926029
Journal J Mol Biol
Year 1982
Volume 162
Pages 645-58
Authors Hughes DL, Sieker LC, Bieth J, Dimicoli JL
Title Crystallographic study of the binding of a trifluoroacetyl dipeptide anilide inhibitor with elastase.
Related PDB 2est
Related UniProtKB
[4]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID
Journal J Am Chem Soc
Year 1985
Volume 107
Pages 4091-3
Authors Meyer EF Jr, Presta LG, Radhakrishnan R
Title Stereospecific reaction of 3-methoxy-4-chloro-7-aminoisocoumarin with crystalline porcine pancreatic elastase.
Related PDB 1jim
Related UniProtKB
[5]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 3640831
Journal J Mol Biol
Year 1986
Volume 189
Pages 533-9
Authors Meyer EF Jr, Radhakrishnan R, Cole GM, Presta LG
Title Structure of the product complex of acetyl-Ala-Pro-Ala with porcine pancreatic elastase at 1.65 A resolution.
Related PDB 1nes
Related UniProtKB
[6]
Resource
Comments
Medline ID
PubMed ID 3504964
Journal J Comput Aided Mol Des
Year 1987
Volume 1
Pages 211-7
Authors Lesyng B, Meyer EF Jr
Title Energy minimization and molecular dynamics studies of Asn-102 elastase.
Related PDB
Related UniProtKB
[7]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 3430613
Journal J Mol Biol
Year 1987
Volume 198
Pages 417-24
Authors Radhakrishnan R, Presta LG, Meyer EF Jr, Wildonger R
Title Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors.
Related PDB 1inc
Related UniProtKB
[8]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 3271103
Journal Acta Crystallogr B
Year 1988
Volume 44
Pages 26-38
Authors Meyer E, Cole G, Radhakrishnan R, Epp O
Title Structure of native porcine pancreatic elastase at 1.65 A resolutions.
Related PDB 3est
Related UniProtKB
[9]
Resource
Comments
Medline ID
PubMed ID 3349061
Journal Biochemistry
Year 1988
Volume 27
Pages 725-30
Authors Meyer EF Jr, Clore GM, Gronenborn AM, Hansen HA
Title Analysis of an enzyme-substrate complex by X-ray crystallography and transferred nuclear Overhauser enhancement measurements: porcine pancreatic elastase and a hexapeptide.
Related PDB
Related UniProtKB
[10]
Resource
Comments
Medline ID
PubMed ID 2655701
Journal Biochemistry
Year 1989
Volume 28
Pages 1951-63
Authors Bode W, Meyer E Jr, Powers JC
Title Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
Related PDB
Related UniProtKB
[11]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 2611205
Journal Biochemistry
Year 1989
Volume 28
Pages 7610-7
Authors Takahashi LH, Radhakrishnan R, Rosenfield RE Jr, Meyer EF Jr
Title Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate.
Related PDB 5est
Related UniProtKB
[12]
Resource
Comments
Medline ID
PubMed ID 2930798
Journal Biochim Biophys Acta
Year 1989
Volume 995
Pages 201-3
Authors Fitzpatrick PF
Title Identification of the rate-limiting step in serine proteinases from the effect of temperature on steady-state kinetics.
Related PDB
Related UniProtKB
[13]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID
Journal J Am Chem Soc
Year 1989
Volume 111
Pages 3368-74
Authors Takahashi LH, Radhakrishnan R, Rosenfieldjunior RE, Meyer EF Jr, Trainor DA
Title Crystal structure of the covalent complex formed by a peptidyl .alpha.,.alpha.-difluoro-.beta.-keto amide with porcine pancreatic elastase at 1.78 .ANG. Resolution
Related PDB 4est
Related UniProtKB
[14]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 2337582
Journal Biochemistry
Year 1990
Volume 29
Pages 3108-18
Authors Powers JC, Oleksyszyn J, Narasimhan SL, Kam CM
Title Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin.
Related PDB 8est
Related UniProtKB
[15]
Resource
Comments
Medline ID
PubMed ID 2205243
Journal Biol Chem Hoppe Seyler
Year 1990
Volume 371 Suppl
Pages 59-64
Authors Meyer E, Geller M
Title Irregular elastase complexes: crystallographic and molecular dynamics studies of small inhibitors and water.
Related PDB
Related UniProtKB
[16]
Resource
Comments
Medline ID
PubMed ID 2275978
Journal Biopolymers
Year 1990
Volume 30
Pages 781-96
Authors Geller M, Carlson-Golab G, Lesyng B, Swanson SM, Meyer EF Jr
Title Dynamic properties of the first enzymatic reaction steps of porcine pancreatic elastase. How rigid is the active site of the native enzyme? Molecular dynamics simulation.
Related PDB
Related UniProtKB
[17]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 2354062
Journal J Mol Recognit
Year 1990
Volume 3
Pages 36-44
Authors de la Sierra IL, Papamichael E, Sakarellos C, Dimicoli JL, Prange T
Title Interaction of the peptide CF3-Leu-Ala-NH-C6H4-CF3 (TFLA) with porcine pancreatic elastase. X-ray studies at 1.8 A.
Related PDB 6est 7est
Related UniProtKB
[18]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 1998677
Journal Biochemistry
Year 1991
Volume 30
Pages 2175-83
Authors Vijayalakshmi J, Meyer EF Jr, Kam CM, Powers JC
Title Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex.
Related PDB 9est
Related UniProtKB
[19]
Resource
Comments
Medline ID
PubMed ID 8298497
Journal Biochem Mol Biol Int
Year 1993
Volume 31
Pages 685-92
Authors Bru R, Walde P
Title Catalytic activity of elastase in reverse micelles.
Related PDB
Related UniProtKB
[20]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 8049229
Journal Biochemistry
Year 1994
Volume 33
Pages 9285-93
Authors Ding X, Rasmussen BF, Petsko GA, Ringe D
Title Direct structural observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate by elastase.
Related PDB 1esa 1esb
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID 8005753
Journal Int J Pept Protein Res
Year 1994
Volume 43
Pages 297-304
Authors Amour A, Collet A, Dubar C, Reboud-Ravaux M
Title Synthesis and protease-catalyzed hydrolysis of a novel hydrazinopeptide.
Related PDB
Related UniProtKB
[22]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 7932559
Journal J Med Chem
Year 1994
Volume 37
Pages 3313-26
Authors Bernstein PR, Andisik D, Bradley PK, Bryant CB, Ceccarelli C, Damewood JR Jr, Earley R, Edwards PD, Feeney S, Gomes BC, et al
Title Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.
Related PDB 1eas
Related UniProtKB
[23]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 7656008
Journal Nat Struct Biol
Year 1994
Volume 1
Pages 55-8
Authors Mattos C, Rasmussen B, Ding X, Petsko GA, Ringe D
Title Analogous inhibitors of elastase do not always bind analogously.
Related PDB 1ela 1elb 1elc
Related UniProtKB
[24]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF COMPLEX WITH INHIBITOR
Medline ID
PubMed ID 7922044
Journal Structure
Year 1994
Volume 2
Pages 679-89
Authors Huang K, Strynadka NC, Bernard VD, Peanasky RJ, James MN
Title The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase.
Related PDB 1eai
Related UniProtKB P00772
[25]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 15299762
Journal Acta Crystallogr D Biol Crystallogr
Year 1995
Volume 51
Pages 925-37
Authors Berglund GI, Willassen NP, Hordvik A, Smalas AO
Title Structure of native pancreatic elastase from North Atlantic salmon at 1.61 A resolution.
Related PDB 1elt
Related UniProtKB
[26]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 7779821
Journal Biochemistry
Year 1995
Volume 34
Pages 7749-56
Authors Ding X, Rasmussen BF, Demuth HU, Ringe D, Steinmetz AC
Title Nature of the inactivation of elastase by N-peptidyl-O-aroyl hydroxylamine as a function of pH.
Related PDB 1elf 1elg
Related UniProtKB
[27]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 7880814
Journal Biochemistry
Year 1995
Volume 34
Pages 3193-203
Authors Mattos C, Giammona DA, Petsko GA, Ringe D
Title Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors.
Related PDB 1eld 1ele
Related UniProtKB
[28]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 7837235
Journal J Med Chem
Year 1995
Volume 38
Pages 212-5
Authors Bernstein PR, Gomes BC, Kosmider BJ, Vacek EP, Williams JC
Title Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone.
Related PDB 1eau
Related UniProtKB
[29]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 7837246
Journal J Med Chem
Year 1995
Volume 38
Pages 98-108
Authors Veale CA, Bernstein PR, Bryant C, Ceccarelli C, Damewood JR Jr, Earley R, Feeney SW, Gomes B, Kosmider BJ, Steelman GB, et al
Title Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones.
Related PDB 1eat
Related UniProtKB
[30]
Resource
Comments
Medline ID
PubMed ID 7837244
Journal J Med Chem
Year 1995
Volume 38
Pages 86-97
Authors Veale CA, Damewood JR Jr, Steelman GB, Bryant C, Gomes B, Williams J
Title Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of beta-carbolinone-containing trifluoromethyl ketones.
Related PDB
Related UniProtKB
[31]
Resource
Comments
Medline ID
PubMed ID 7613461
Journal Protein Sci
Year 1995
Volume 4
Pages 613-21
Authors Huntington JA, Patston PA, Gettins PG
Title S-ovalbumin, an ovalbumin conformer with properties analogous to those of loop-inserted serpins.
Related PDB
Related UniProtKB
[32]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 7604279
Journal Science
Year 1995
Volume 269
Pages 66-9
Authors Peisach E, Casebier D, Gallion SL, Furth P, Petsko GA, Hogan JC Jr, Ringe D
Title Interaction of a peptidomimetic aminimide inhibitor with elastase.
Related PDB 1bma
Related UniProtKB
[33]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 8794736
Journal Biochemistry
Year 1996
Volume 35
Pages 11570-6
Authors Tsunemi M, Matsuura Y, Sakakibara S, Katsube Y
Title Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution.
Related PDB 1fle
Related UniProtKB
[34]
Resource
Comments
Medline ID
PubMed ID 9630949
Journal Nat Biotechnol
Year 1996
Volume 14
Pages 595-9
Authors Mattos C, Ringe D
Title Locating and characterizing binding sites on proteins.
Related PDB
Related UniProtKB
[35]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 15299973
Journal Acta Crystallogr D Biol Crystallogr
Year 1997
Volume 53
Pages 78-92
Authors Schiltz M, Shepard W, Fourme R, Prange T, de la Fortelle E, Bricogne G
Title High-pressure krypton gas and statistical heavy-atom refinement: a successful combination of tools for macromolecular structure determination.
Related PDB 1lvy
Related UniProtKB
[36]
Resource
Comments
Medline ID
PubMed ID 9159490
Journal J Mol Biol
Year 1997
Volume 268
Pages 557-69
Authors Baker BM, Murphy KP
Title Dissecting the energetics of a protein-protein interaction: the binding of ovomucoid third domain to elastase.
Related PDB
Related UniProtKB
[37]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 9187653
Journal Nat Struct Biol
Year 1997
Volume 4
Pages 456-62
Authors Wilmouth RC, Clifton IJ, Robinson CV, Roach PL, Aplin RT, Westwood NJ, Hajdu J, Schofield CJ
Title Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase.
Related PDB 1qix
Related UniProtKB
[38]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 9860865
Journal Biochemistry
Year 1998
Volume 37
Pages 17506-13
Authors Wilmouth RC, Westwood NJ, Anderson K, Brownlee W, Claridge TD, Clifton IJ, Pritchard GJ, Aplin RT, Schofield CJ
Title Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex.
Related PDB 1btu
Related UniProtKB
[39]
Resource
Comments
Medline ID
PubMed ID 9504720
Journal Biol Chem
Year 1998
Volume 379
Pages 71-4
Authors Haensler M, Wehofsky N, Gerisch S, Wissmann JD, Jakubke HD
Title Reverse catalysis of elastase from porcine pancreas in frozen aqueous systems.
Related PDB
Related UniProtKB
[40]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 9651152
Journal J Med Chem
Year 1998
Volume 41
Pages 2461-80
Authors Cregge RJ, Durham SL, Farr RA, Gallion SL, Hare CM, Hoffman RV, Janusz MJ, Kim HO, Koehl JR, Mehdi S, Metz WA, Peet NP, Pelton JT, Schreuder HA, Sunder S, Tardif C
Title Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.
Related PDB 1b0e
Related UniProtKB
[41]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 9443341
Journal Proteins
Year 1998
Volume 30
Pages 61-73
Authors Prange T, Schiltz M, Pernot L, Colloc'h N, Longhi S, Bourguet W, Fourme R
Title Exploring hydrophobic sites in proteins with xenon or krypton.
Related PDB 1c1m
Related UniProtKB
[42]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 10387042
Journal Biochemistry
Year 1999
Volume 38
Pages 7989-98
Authors Wilmouth RC, Kassamally S, Westwood NJ, Sheppard RJ, Claridge TD, Aplin RT, Wright PA, Pritchard GJ, Schofield CJ
Title Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.
Related PDB 1qgf
Related UniProtKB
[43]
Resource
Comments
Medline ID
PubMed ID 10455164
Journal J Biol Chem
Year 1999
Volume 274
Pages 24901-5
Authors Taylor P, Anderson V, Dowden J, Flitsch SL, Turner NJ, Loughran K, Walkinshaw MD
Title Novel mechanism of inhibition of elastase by beta-lactams is defined by two inhibitor crystal complexes.
Related PDB
Related UniProtKB
[44]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 10739939
Journal Acta Crystallogr D Biol Crystallogr
Year 2000
Volume 56
Pages 520-3
Authors Wurtele M, Hahn M, Hilpert K, Hohne W
Title Atomic resolution structure of native porcine pancreatic elastase at 1.1 A.
Related PDB 1qnj
Related UniProtKB
[45]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11023818
Journal Biochem J
Year 2000
Volume 351 Pt 2
Pages 335-40
Authors Wright PA, Wilmouth RC, Clifton IJ, Schofield CJ
Title 'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes.
Related PDB 1e34 1e35 1e36 1e37 1e38
Related UniProtKB
[46]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 10738204
Journal Biopolymers
Year 2000
Volume 53
Pages 434-45
Authors Nakanishi I, Kinoshita T, Sato A, Tada T
Title Structure of porcine pancreatic elastase complexed with FR901277, a novel macrocyclic inhibitor of elastases, at 1.6 A resolution.
Related PDB 1qr3
Related UniProtKB
[47]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11310599
Journal Bioorg Med Chem
Year 2001
Volume 9
Pages 647-51
Authors Odagaki Y, Ohmoto K, Matsuoka S, Hamanaka N, Nakai H, Toda M, Katsuya Y
Title The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase.
Related PDB 1fzz
Related UniProtKB
[48]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11294386
Journal Bioorg Med Chem Lett
Year 2001
Volume 11
Pages 895-8
Authors Macdonald SJ, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H
Title The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.
Related PDB 1hv7
Related UniProtKB
[49]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11358514
Journal Eur J Biochem
Year 2001
Volume 268
Pages 2969-74
Authors Wright PA, Wilmouth RC, Clifton IJ, Schofield CJ
Title Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein.
Related PDB 1h9l
Related UniProtKB
[50]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11473259
Journal Nat Struct Biol
Year 2001
Volume 8
Pages 689-94
Authors Wilmouth RC, Edman K, Neutze R, Wright PA, Clifton IJ, Schneider TR, Schofield CJ, Hajdu J
Title X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.
Related PDB 1hax 1hay 1haz 1hb0
Related UniProtKB
[51]
Resource
Comments
Medline ID
PubMed ID 11730873
Journal Phytochemistry
Year 2001
Volume 58
Pages 1087-95
Authors Matern U, Oberer L, Falchetto RA, Erhard M, Konig WA, Herdman M, Weckesser J
Title Scyptolin A and B, cyclic depsipeptides from axenic cultures of Scytonema hofmanni PCC 7110.
Related PDB
Related UniProtKB
[52]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12037300
Journal Acta Crystallogr D Biol Crystallogr
Year 2002
Volume 58
Pages 976-91
Authors Evans G, Bricogne G
Title Triiodide derivatization and combinatorial counter-ion replacement: two methods for enhancing phasing signal using laboratory Cu Kalpha X-ray equipment.
Related PDB 1gwa
Related UniProtKB
[53]
Resource
Comments
Medline ID
PubMed ID 11914493
Journal Acta Crystallogr D Biol Crystallogr
Year 2002
Volume 58
Pages 672-4
Authors Hilpert K, Schneider-Mergener J, Ay J
Title Crystallization and preliminary X-ray analysis of the complex of porcine pancreatic elastase and a hybrid squash inhibitor.
Related PDB
Related UniProtKB
[54]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12198297
Journal Acta Crystallogr D Biol Crystallogr
Year 2002
Volume 58
Pages 1413-20
Authors Panjikar S, Tucker PA
Title Xenon derivatization of halide-soaked protein crystals.
Related PDB 1l0z 1l1g 1lka 1lkb
Related UniProtKB
[55]
Resource
Comments
Medline ID
PubMed ID 12109112
Journal Chem Commun (Camb)
Year 2002
Volume -12
Pages 1274-5
Authors Migaud ME, Wilmouth RC, Mills GI, Wayne GJ, Risley C, Chambers C, Macdonald SJ, Schofield CJ
Title 5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
Related PDB
Related UniProtKB
[56]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11896054
Journal J Biol Chem
Year 2002
Volume 277
Pages 21962-70
Authors Katona G, Wilmouth RC, Wright PA, Berglund GI, Hajdu J, Neutze R, Schofield CJ
Title X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution.
Related PDB 1gvk
Related UniProtKB
[57]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12554935
Journal Acta Crystallogr D Biol Crystallogr
Year 2003
Volume 59
Pages 247-54
Authors Ay J, Hilpert K, Krauss N, Schneider-Mergener J, Hohne W
Title Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution.
Related PDB 1mcv
Related UniProtKB
[58]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12467609
Journal Bioorg Med Chem Lett
Year 2003
Volume 13
Pages 21-4
Authors Kinoshita T, Nakanishi I, Sato A, Tada T
Title True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor.
Related PDB 1mmj
Related UniProtKB
[59]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 14583266
Journal Chem Biol
Year 2003
Volume 10
Pages 997-1001
Authors Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE
Title Binding structure of elastase inhibitor scyptolin A.
Related PDB 1okx
Related UniProtKB
[60]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID
Journal Acta Crystallogr D Biol Crystallogr
Year 2004
Volume 60
Pages 28-38
Authors Mueller-Dieckmann C, Polentarutti M, Djinovic-Carugo K, Panjikar S, Tucker PA, Weiss MS
Title On the Routine Use of Soft X-Rays in Macromolecular Crystallography. Part II. Data-Collection Wavelength and Scaling Models.
Related PDB 1uo6
Related UniProtKB
[61]
Resource
Comments
Medline ID
PubMed ID 14593107
Journal J Biol Chem
Year 2004
Volume 279
Pages 9264-9
Authors Dobo J, Gettins PG
Title alpha1-Proteinase inhibitor forms initial non-covalent and final covalent complexes with elastase analogously to other serpin-proteinase pairs, suggesting a common mechanism of inhibition.
Related PDB
Related UniProtKB

Comments
E.C. 3.4.21.11 was Transferred to EC 3.4.21.36 and 3.4.21.37.
This enzyme belongs to the peptidase family-S1.
Although this enzyme binds a calcium ion, it is not involved in catalysis.
As this enzyme has got a catalytic triad composed of Ser/His/Asp, it should have a similar mechanism to that of trypsin (D00197 in EzCatDB).

Created Updated
2004-03-25 2011-02-22