DB code: D00469

CATH domain 1.25.40.10 : Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
-.-.-.- :
E.C. 3.1.3.16
CSA
M-CSA
MACiE

CATH domain Related DB codes (homologues)
1.25.40.10 : Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat M00184

Uniprot Enzyme Name
UniprotKB Protein name Synonyms RefSeq Pfam
P53041 Serine/threonine-protein phosphatase 5
PP5
EC 3.1.3.16
Protein phosphatase T
PP-T
PPT
NP_006238.1 (Protein)
NM_006247.3 (DNA/RNA sequence)
PF00149 (Metallophos)
PF08321 (PPP5)
PF00515 (TPR_1)
[Graphical View]

KEGG enzyme name
phosphoprotein phosphatase
protein phosphatase-1
protein phosphatase-2A
protein phosphatase-2B
protein phosphatase-2C
protein D phosphatase
phosphospectrin phosphatase
casein phosphatase
Aspergillus awamori acid protein phosphatase
calcineurin
phosphatase 2A
phosphatase 2B
phosphatase II
phosphatase IB
phosphatase C-II
polycation modulated (PCM-) phosphatase
phosphopyruvate dehydrogenase phosphatase
phosphatase SP
branched-chain alpha-keto acid dehydrogenase phosphatase
BCKDH phosphatase
3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
HMG-CoA reductase phosphatase
phosphatase H-II
phosphatase III
phosphatase I
protein phosphatase
phosphatase IV

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P53041 PPP5_HUMAN A phosphoprotein + H(2)O = a protein + phosphate. Interacts with CDC16 and CDC27. Nucleus. Cytoplasm. Note=Predominantly nuclear. But also present in the cytoplasm. Binds 1 iron ion per subunit (By similarity). Binds 1 manganese ion per subunit (By similarity).

KEGG Pathways
Map code Pathways E.C.

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00076 C00391 C00023 C00034 C00562 C00001 L00078 C02734 C01976 C00017 C00009
E.C.
Compound Calcium Calmodulin Iron Manganese Phosphoprotein H2O Casein Phenolic phosphate Phosphoamide Protein Orthophosphate
Type divalent metal (Ca2+, Mg2+) peptide/protein heavy metal heavy metal peptide/protein,phosphate group/phosphate ion H2O peptide/protein,phosphate group/phosphate ion aromatic ring (only carbon atom),phosphate group/phosphate ion amine group,phosphate group/phosphate ion peptide/protein phosphate group/phosphate ion
ChEBI 29108
18248
82664
18291
35154
15377
37548
26078
PubChem 271
23925
23930
22247451
962
12793
1004
22486802
1a17A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Analogue:SO4

Reference for Active-site residues
resource references E.C.

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1a17A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain

References for Catalytic Mechanism
References Sections No. of steps in catalysis

References
[1]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 19-177.
Medline ID
PubMed ID 9482716
Journal EMBO J
Year 1998
Volume 17
Pages 1192-9.
Authors Das AK, Cohen PW, Barford D
Title The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.
Related PDB 1a17
Related UniProtKB P53041
[2]
Resource
Comments
Medline ID
PubMed ID 11881984
Journal J Med Chem
Year 2002
Volume 45
Pages 1151-75.
Authors McCluskey A, Sim AT, Sakoff JA
Title Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.
Related PDB
Related UniProtKB

Comments
The tertiary structure of the C-terminal catalytic domain has not been determined yet.

Created Updated
2004-03-19 2012-06-26