DB code: D00490

CATH domain 3.90.180.10 : Quinone Oxidoreductase; Chain A, domain 1 Catalytic domain
3.40.50.720 : Rossmann fold Catalytic domain
E.C. 1.1.1.1
CSA
M-CSA
MACiE

CATH domain Related DB codes (homologues)
3.90.180.10 : Quinone Oxidoreductase; Chain A, domain 1 D00001 D00002 D00018 D00048 D00481 D00482 D00492 D00615
3.40.50.720 : Rossmann fold S00543 S00551 S00552 S00553 S00602 S00604 S00605 S00608 S00610 S00625 S00319 S00328 S00329 S00330 S00331 S00332 D00456 D00457 D00458 S00324 S00320 S00325 S00326 S00327 D00459 S00335 S00336 S00334 T00219 S00339 D00513 D00001 D00002 D00003 D00005 D00007 D00008 D00010 D00012 D00017 D00018 D00023 D00027 D00028 D00031 D00032 D00033 D00034 D00035 D00037 D00048 D00071 D00476 D00481 D00482 D00492 D00494 D00545 D00601 D00603 D00604 D00605 D00615 D00845 D00857 D00858 M00161 M00171 M00210 T00002 T00010 T00011 T00015 T00227 T00247 T00408 T00414 D00827 D00262 D00274 D00275 M00035 T00109

Uniprot Enzyme Name
UniprotKB Protein name Synonyms Pfam
P26325 Alcohol dehydrogenase 1
EC 1.1.1.1
PF08240 (ADH_N)
PF00107 (ADH_zinc_N)
[Graphical View]

KEGG enzyme name
alcohol dehydrogenase
aldehyde reductase
ADH
alcohol dehydrogenase (NAD)
aliphatic alcohol dehydrogenase
ethanol dehydrogenase
NAD-dependent alcohol dehydrogenase
NAD-specific aromatic alcohol dehydrogenase
NADH-alcohol dehydrogenase
NADH-aldehyde dehydrogenase
primary alcohol dehydrogenase
yeast alcohol dehydrogenase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P26325 ADH1_GADCA An alcohol + NAD(+) = an aldehyde or ketone + NADH. Homodimer. Cytoplasm. Binds 2 zinc ions per subunit.

KEGG Pathways
Map code Pathways E.C.
MAP00010 Glycolysis / Gluconeogenesis
MAP00071 Fatty acid metabolism
MAP00120 Bile acid biosynthesis
MAP00260 Glycine, serine and threonine metabolism
MAP00350 Tyrosine metabolism
MAP00624 1- and 2-Methylnaphthalene degradation
MAP00641 3-Chloroacrylic acid degradation
MAP00830 Retinol metabolism
MAP00980 Metabolism of xenobiotics by cytochrome P450
MAP00982 Drug metabolism - cytochrome P450

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00038 C00003 C00226 C00069 C00004 C00071 C00709 C00080
E.C.
Compound Zinc NAD+ Primary alcohol Alcohol NADH Aldehyde Ketone H+
Type heavy metal amide group,amine group,nucleotide carbohydrate carbohydrate amide group,amine group,nucleotide carbohydrate carbohydrate others
ChEBI 29105
15846
16908
15378
PubChem 32051
5893
439153
1038
1cdoA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_ZN Bound:NAD Unbound Unbound Unbound Unbound Unbound
1cdoB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_ZN Bound:NAD Unbound Unbound Unbound Unbound Unbound
1cdoA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:NAD Unbound Unbound Unbound Unbound Unbound
1cdoB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:NAD Unbound Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
Swiss-prot;P40394, P00325, P00327, P00326, P00328,P26325

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1cdoA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 47;THR 48 CYS 46;HIS 68;CYS 175(Catalytic zinc binding)
1cdoB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 47;THR 48 CYS 46;HIS 68;CYS 175(Catalytic zinc binding)
1cdoA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1cdoB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[3]
p.582-586
[6]
p.437-438
[9]
Fig.4, p.1065-1067
[12]
Fig.2, p.619-621, p.624-625
[31]
p.5235-5237
[33]
p.273
[34]
p.425-428
[43]
Fig.2, p.9786-9789, p.9790-9791
[44]
p.135-136
[49]
p.666-667
[61]
Scheme 1, p.13957-13959
[66]
Chart 1, Chart 2, p.11955-11956, p.11957-11959
[67]
Fig.5, p.9320
[70]
Scheme 2, p.480
[73]
Fig.3
[78]
Scheme 1, p.3023-3025

References
[1]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
Medline ID 76193761
PubMed ID 178875
Journal J Mol Biol
Year 1976
Volume 102
Pages 27-59
Authors Eklund H, Nordstrom B, Zeppezauer E, Soderlund G, Ohlsson I, Boiwe T, Soderberg BO, Tapia O, Branden CI, Akeson A
Title Three-dimensional structure of horse liver alcohol dehydrogenase at 2-4 A resolution.
Related PDB
Related UniProtKB P00327 P00328
[2]
Resource
Comments
Medline ID
PubMed ID 202459
Journal Eur J Biochem
Year 1977
Volume 81
Pages 403-9
Authors Samama JP, Zeppezauer E, Biellmann JF, Branden CI
Title The crystal structure of complexes between horse liver alcohol dehydrogenase and the coenzyme analogues 3-iodopyridine-adenine dinucleotide and pyridine-adenine dinucleotide.
Related PDB
Related UniProtKB
[3]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 7024556
Journal J Mol Biol
Year 1981
Volume 146
Pages 561-87
Authors Eklund H, Samma JP, Wallen L, Branden CI, Akeson A, Jones TA
Title Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 A resolution.
Related PDB 6adh
Related UniProtKB
[4]
Resource
Comments X-RAY CRYSTALLOGRAPHY.
Medline ID 85122661
PubMed ID 6098306
Journal Biochemistry
Year 1984
Volume 23
Pages 5982-96
Authors Eklund H, Samama JP, Jones TA
Title Crystallographic investigations of nicotinamide adenine dinucleotide binding to horse liver alcohol dehydrogenase.
Related PDB
Related UniProtKB P00327 P00328
[5]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 3771574
Journal J Biol Chem
Year 1986
Volume 261
Pages 15273-80
Authors Colonna-Cesari F, Perahia D, Karplus M, Eklund H, Braden CI, Tapia O
Title Interdomain motion in liver alcohol dehydrogenase. Structural and energetic analysis of the hinge bending mode.
Related PDB 5adh 7adh 8adh
Related UniProtKB
[6]
Resource
Comments
Medline ID
PubMed ID 3608931
Journal Eur Biophys J
Year 1987
Volume 14
Pages 431-9
Authors Bertini I, Lanini G, Luchinat C, Haas C, Maret W, Zeppezauer M
Title The influence of anions and inhibitors on the catalytic metal ion in Co(II)-substituted horse liver alcohol dehydrogenase.
Related PDB
Related UniProtKB
[7]
Resource
Comments
Medline ID
PubMed ID 2322541
Journal Biochemistry
Year 1990
Volume 29
Pages 196-203
Authors Strambini GB, Gonnelli M
Title Tryptophan luminescence from liver alcohol dehydrogenase in its complexes with coenzyme. A comparative study of protein conformation in solution.
Related PDB
Related UniProtKB
[8]
Resource
Comments
Medline ID
PubMed ID 1772423
Journal Biochem Int
Year 1991
Volume 24
Pages 451-60
Authors Fong WP, Keung WM
Title Examination of subunit interaction in human ADH: carboxymethylation of the heterodimer beta 2 gamma 1.
Related PDB
Related UniProtKB
[9]
Resource
Comments
Medline ID
PubMed ID 1989677
Journal Biochemistry
Year 1991
Volume 30
Pages 1062-8
Authors Ehrig T, Hurley TD, Edenberg HJ, Bosron WF
Title General base catalysis in a glutamine for histidine mutant at position 51 of human liver alcohol dehydrogenase.
Related PDB
Related UniProtKB
[10]
Resource
Comments
Medline ID
PubMed ID 2054345
Journal Biochemistry
Year 1991
Volume 30
Pages 6397-401
Authors Fan F, Lorenzen JA, Plapp BV
Title An aspartate residue in yeast alcohol dehydrogenase I determines the specificity for coenzyme.
Related PDB
Related UniProtKB
[11]
Resource
Comments
Medline ID
PubMed ID 1807973
Journal Eur Biophys J
Year 1991
Volume 20
Pages 215-21
Authors Bauer R, Adolph HW, Andersson I, Danielsen E, Formicka G, Zeppezauer M
Title Coordination geometry for cadmium in the catalytic zinc site of horse liver alcohol dehydrogenase: studies by PAC spectroscopy.
Related PDB
Related UniProtKB
[12]
Resource
Comments
Medline ID
PubMed ID 1935957
Journal Eur J Biochem
Year 1991
Volume 201
Pages 615-25
Authors Adolph HW, Maurer P, Schneider-Bernlohr H, Sartorius C, Zeppezauer M
Title Substrate specificity and stereoselectivity of horse liver alcohol dehydrogenase. Kinetic evaluation of binding and activation parameters controlling the catalytic cycles of unbranched, acyclic secondary alcohols and ketones as substrates of the native and active-site-specific Co(II)-substituted enzyme.
Related PDB
Related UniProtKB
[13]
Resource
Comments
Medline ID
PubMed ID 1712777
Journal J Biol Chem
Year 1991
Volume 266
Pages 13296-302
Authors Park DH, Plapp BV
Title Isoenzymes of horse liver alcohol dehydrogenase active on ethanol and steroids. cDNA cloning, expression, and comparison of active sites.
Related PDB
Related UniProtKB
[14]
Resource
Comments X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
Medline ID 91376103
PubMed ID 1896463
Journal Proc Natl Acad Sci U S A
Year 1991
Volume 88
Pages 8149-53
Authors Hurley TD, Bosron WF, Hamilton JA, Amzel LM
Title Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.
Related PDB 3hud
Related UniProtKB P00325
[15]
Resource
Comments
Medline ID
PubMed ID 1368113
Journal Enzyme Microb Technol
Year 1992
Volume 14
Pages 371-5
Authors Kawakami K, Abe T, Yoshida T
Title Silicone-immobilized biocatalysts effective for bioconversions in nonaqueous media.
Related PDB
Related UniProtKB
[16]
Resource
Comments
Medline ID
PubMed ID 1572355
Journal Eur J Biochem
Year 1992
Volume 205
Pages 519-26
Authors Hoog JO, Eklund H, Jornvall H
Title A single-residue exchange gives human recombinant beta beta alcohol dehydrogenase gamma gamma isozyme properties.
Related PDB
Related UniProtKB
[17]
Resource
Comments
Medline ID
PubMed ID 1324852
Journal FEBS Lett
Year 1992
Volume 309
Pages 92-6
Authors Formicka G, Zeppezauer M, Fey F, Huttermann J
Title Copper(II)-substituted horse liver alcohol dehydrogenase: structure of the minor species.
Related PDB
Related UniProtKB
[18]
Resource
Comments
Medline ID
PubMed ID 1544927
Journal J Biol Chem
Year 1992
Volume 267
Pages 5527-33
Authors Park DH, Plapp BV
Title Interconversion of E and S isoenzymes of horse liver alcohol dehydrogenase. Several residues contribute indirectly to catalysis.
Related PDB
Related UniProtKB
[19]
Resource
Comments
Medline ID
PubMed ID 8493927
Journal Adv Exp Med Biol
Year 1993
Volume 328
Pages 481-91
Authors Henehan GT, Kenyon GL, Oppenheimer NJ
Title The oxidation of aldehydes by horse liver alcohol dehydrogenase.
Related PDB
Related UniProtKB
[20]
Resource
Comments
Medline ID
PubMed ID 8493923
Journal Adv Exp Med Biol
Year 1993
Volume 328
Pages 451-5
Authors Hubatsch I, Zeppezauer M, Waidelich D, Bayer E
Title Horse liver alcohol dehydrogenase-S-isozyme: confirmation of the primary structure by protein sequencing and ion spray mass spectrometry.
Related PDB
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID 8493917
Journal Adv Exp Med Biol
Year 1993
Volume 328
Pages 391-400
Authors Plapp BV, Green DW, Sun HW, Park DH, Kim K
Title Substrate specificity of alcohol dehydrogenases.
Related PDB
Related UniProtKB
[22]
Resource
Comments
Medline ID
PubMed ID 8504071
Journal Biochemistry
Year 1993
Volume 32
Pages 5503-7
Authors Bahnson BJ, Park DH, Kim K, Plapp BV, Klinman JP
Title Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis.
Related PDB
Related UniProtKB
[23]
Resource
Comments
Medline ID
PubMed ID 8422379
Journal Biochemistry
Year 1993
Volume 32
Pages 735-8
Authors Henehan GT, Oppenheimer NJ
Title Horse liver alcohol dehydrogenase-catalyzed oxidation of aldehydes: dismutation precedes net production of reduced nicotinamide adenine dinucleotide.
Related PDB
Related UniProtKB
[24]
Resource
Comments
Medline ID
PubMed ID 8218182
Journal Biochemistry
Year 1993
Volume 32
Pages 11186-94
Authors Shearer GL, Kim K, Lee KM, Wang CK, Plapp BV
Title Alternative pathways and reactions of benzyl alcohol and benzaldehyde with horse liver alcohol dehydrogenase.
Related PDB
Related UniProtKB
[25]
Resource
Comments
Medline ID
PubMed ID 8490046
Journal Biochim Biophys Acta
Year 1993
Volume 1163
Pages 144-8
Authors Adlercreutz P
Title Activation of enzymes in organic media at low water activity by polyols and saccharides.
Related PDB
Related UniProtKB
[26]
Resource
Comments
Medline ID
PubMed ID 7684231
Journal Enzyme Microb Technol
Year 1993
Volume 15
Pages 383-92
Authors Creagh AL, Prausnitz JM, Blanch HW
Title Structural and catalytic properties of enzymes in reverse micelles.
Related PDB
Related UniProtKB
[27]
Resource
Comments
Medline ID
PubMed ID 8354263
Journal Eur J Biochem
Year 1993
Volume 215
Pages 567-72
Authors Shilton BH, Campbell RL, Walton DJ
Title Site specificity of glycation of horse liver alcohol dehydrogenase in vitro.
Related PDB
Related UniProtKB
[28]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS)
Medline ID
PubMed ID
Journal Acta Crystallogr D Biol Crystallogr
Year 1994
Volume 50
Pages 793-807
Authors Al-Karadaghi S, Cedergren-Zeppezauer ES, Hovmoeller S, Petratos K, Terry H, Wilson KS
Title Refined crystal structure of liver alcohol dehydrogenase-NADH complex at 1.8-A resolution.
Related PDB
Related UniProtKB P00327
[29]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 8286346
Journal Biochemistry
Year 1994
Volume 33
Pages 23-32
Authors Li H, Hallows WH, Punzi JS, Marquez VE, Carrell HL, Pankiewicz KW, Watanabe KA, Goldstein BM
Title Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Related PDB 1adf 1adg
Related UniProtKB
[30]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 7918390
Journal Biochemistry
Year 1994
Volume 33
Pages 11734-44
Authors Li H, Hallows WH, Punzi JS, Pankiewicz KW, Watanabe KA, Goldstein BM
Title Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.
Related PDB 1adb 1adc
Related UniProtKB
[31]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 8172897
Journal Biochemistry
Year 1994
Volume 33
Pages 5230-7
Authors Ramaswamy S, Eklund H, Plapp BV
Title Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols.
Related PDB 1hld
Related UniProtKB
[32]
Resource
Comments
Medline ID
PubMed ID 7957193
Journal Eur J Biochem
Year 1994
Volume 225
Pages 1015-9
Authors Jelokova J, Karlsson C, Estonius M, Jornvall H, Hoog JO
Title Features of structural zinc in mammalian alcohol dehydrogenase. Site-directed mutagenesis of the zinc ligands.
Related PDB
Related UniProtKB
[33]
Resource
Comments
Medline ID
PubMed ID 8032158
Journal EXS
Year 1994
Volume 71
Pages 269-77
Authors Eklund H, Ramaswamy S, Plapp BV, el-Ahmad M, Danielsson O, Hoog JO, Jornvall H
Title Crystallographic investigations of alcohol dehydrogenases.
Related PDB
Related UniProtKB
[34]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS).
Medline ID 94260547
PubMed ID 8201622
Journal J Mol Biol
Year 1994
Volume 239
Pages 415-29
Authors Hurley TD, Bosron WF, Stone CL, Amzel LM
Title Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.
Related PDB 1hdx 1hdy 1hdz
Related UniProtKB P00325
[35]
Resource
Comments
Medline ID
PubMed ID 8127901
Journal Proc Natl Acad Sci U S A
Year 1994
Volume 91
Pages 1893-7
Authors Pares X, Cederlund E, Moreno A, Hjelmqvist L, Farres J, Jornvall H
Title Mammalian class IV alcohol dehydrogenase (stomach alcohol dehydrogenase): structure, origin, and correlation with enzymology.
Related PDB
Related UniProtKB
[36]
Resource
Comments
Medline ID
PubMed ID 7484400
Journal Adv Exp Med Biol
Year 1995
Volume 372
Pages 365-71
Authors el-Ahmad M, Ramaswamy S, Danielsson O, Karlsson C, Estonius M, Hoog JO, Eklund H, Jornvall H
Title Crystallizations of novel forms of alcohol dehydrogenase.
Related PDB
Related UniProtKB
[37]
Resource
Comments
Medline ID
PubMed ID 7484389
Journal Adv Exp Med Biol
Year 1995
Volume 372
Pages 281-94
Authors Jornvall H, Danielsson O, Hjelmqvist L, Persson B, Shafqat J
Title The alcohol dehydrogenase system.
Related PDB
Related UniProtKB
[38]
Resource
Comments
Medline ID
PubMed ID 7766625
Journal Biochemistry
Year 1995
Volume 34
Pages 7145-53
Authors Hemmingsen L, Bauer R, Bjerrum MJ, Zeppezauer M, Adolph HW, Formicka G, Cedergren-Zeppezauer E
Title Cd-substituted horse liver alcohol dehydrogenase: catalytic site metal coordination geometry and protein conformation.
Related PDB
Related UniProtKB
[39]
Resource
Comments
Medline ID
PubMed ID 7479907
Journal Proc Natl Acad Sci U S A
Year 1995
Volume 92
Pages 10904-8
Authors Hjelmqvist L, Estonius M, Jornvall H
Title The vertebrate alcohol dehydrogenase system: variable class II type form elucidates separate stages of enzymogenesis.
Related PDB
Related UniProtKB
[40]
Resource
Comments
Medline ID
PubMed ID 7549877
Journal Protein Sci
Year 1995
Volume 4
Pages 1124-32
Authors Ryde U
Title On the role of Glu-68 in alcohol dehydrogenase.
Related PDB
Related UniProtKB
[41]
Resource
Comments
Medline ID
PubMed ID 8638928
Journal Arch Biochem Biophys
Year 1996
Volume 328
Pages 173-83
Authors Edwards KJ, Barton JD, Rossjohn J, Thorn JM, Taylor GL, Ollis DL
Title Structural and sequence comparisons of quinone oxidoreductase, zeta-crystallin, and glucose and alcohol dehydrogenases.
Related PDB
Related UniProtKB
[42]
Resource
Comments
Medline ID
PubMed ID 8713071
Journal Biochem J
Year 1996
Volume 317
Pages 447-56
Authors Farrar JA, Formicka G, Zeppezauer M, Thomson AJ
Title Magnetic and optical properties of copper-substituted alcohol dehydrogenase: a bisthiolate copper (II) complex.
Related PDB
Related UniProtKB
[43]
Resource
Comments
Medline ID
PubMed ID 8703951
Journal Biochemistry
Year 1996
Volume 35
Pages 9782-91
Authors Olson LP, Luo J, Almarsson O, Bruice TC
Title Mechanism of aldehyde oxidation catalyzed by horse liver alcohol dehydrogenase.
Related PDB
Related UniProtKB
[44]
Resource
Comments
Medline ID
PubMed ID 8695638
Journal Biochim Biophys Acta
Year 1996
Volume 1295
Pages 125-38
Authors Vanhommerig SA, Sluyterman LA, Meijer EM
Title Kinetic and modelling studies of NAD+ and poly(ethylene glycol)-bound NAD+ in horse liver alcohol dehydrogenase.
Related PDB
Related UniProtKB
[45]
Resource
Comments
Medline ID
PubMed ID 8917454
Journal Eur J Biochem
Year 1996
Volume 241
Pages 546-51
Authors Hemmingsen L, Bauer R, Bjerrum MJ, Adolph HW, Zeppezauer M, Cedergren-Zeppezauer E
Title The protein conformation of Cd-substituted horse liver alcohol dehydrogenase and its metal-site coordination geometry in binary and ternary inhibitor complexes.
Related PDB
Related UniProtKB
[46]
Resource
Comments
Medline ID
PubMed ID 8612630
Journal Eur J Biochem
Year 1996
Volume 236
Pages 563-70
Authors Hjelmqvist L, Shafqat J, Siddiqi AR, Jornvall H
Title Linking of isozyme and class variability patterns in the emergence of novel alcohol dehydrogenase functions. Characterization of isozymes in Uromastix hardwickii.
Related PDB
Related UniProtKB
[47]
Resource
Comments
Medline ID
PubMed ID 8898073
Journal FEBS Lett
Year 1996
Volume 395
Pages 99-102
Authors Moreno A, Farres J, Pares X, Jornvall H, Persson B
Title Molecular modelling of human gastric alcohol dehydrogenase (class IV) and substrate docking: differences towards the classical liver enzyme (class I).
Related PDB
Related UniProtKB
[48]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
Medline ID 96291846
PubMed ID 8663387
Journal J Biol Chem
Year 1996
Volume 271
Pages 17057-61
Authors Davis GJ, Bosron WF, Stone CL, Owusu-Dekyi K, Hurley TD
Title X-ray structure of human beta3beta3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding.
Related PDB 1deh 1htb
Related UniProtKB P00325
[49]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).
Medline ID 96259224
PubMed ID 8845755
Journal Protein Sci
Year 1996
Volume 5
Pages 663-71
Authors Ramaswamy S, el Ahmad M, Danielsson O, Jornvall H, Eklund H
Title Crystal structure of cod liver class I alcohol dehydrogenase: substrate pocket and structurally variable segments.
Related PDB 1cdo
Related UniProtKB P26325
[50]
Resource
Comments
Medline ID
PubMed ID 9059633
Journal Adv Exp Med Biol
Year 1997
Volume 414
Pages 291-302
Authors Hurley TD, Steinmetz CG, Xie P, Yang ZN
Title Three-dimensional structures of human alcohol dehydrogenase isoenzymes reveal the molecular basis for their functional diversity.
Related PDB
Related UniProtKB
[51]
Resource
Comments
Medline ID
PubMed ID 9059632
Journal Adv Exp Med Biol
Year 1997
Volume 414
Pages 281-9
Authors Jornvall H, Shafqat J, el-Ahmad M, Hjelmqvist L, Persson B, Danielsson O
Title Alcohol dehydrogenase variability. Evolutionary and functional conclusions from characterization of further variants.
Related PDB
Related UniProtKB
[52]
Resource
Comments
Medline ID
PubMed ID 9220961
Journal Biochemistry
Year 1997
Volume 36
Pages 8743-54
Authors Adolph HW, Kiefer M, Cedergren-Zeppezauer E
Title Electrostatic effects in the kinetics of coenzyme binding to isozymes of alcohol dehydrogenase from horse liver.
Related PDB
Related UniProtKB
[53]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 9003191
Journal Biochemistry
Year 1997
Volume 36
Pages 382-9
Authors Cho H, Ramaswamy S, Plapp BV
Title Flexibility of liver alcohol dehydrogenase in stereoselective binding of 3-butylthiolane 1-oxides.
Related PDB 1bto 3bto
Related UniProtKB
[54]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 9132002
Journal Biochemistry
Year 1997
Volume 36
Pages 3522-7
Authors Ramaswamy S, Scholze M, Plapp BV
Title Binding of formamides to liver alcohol dehydrogenase.
Related PDB 1lde 1ldy
Related UniProtKB
[55]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 9371755
Journal Proc Natl Acad Sci U S A
Year 1997
Volume 94
Pages 12797-802
Authors Bahnson BJ, Colby TD, Chin JK, Goldstein BM, Klinman JP
Title A link between protein structure and enzyme catalyzed hydrogen tunneling.
Related PDB 1axe 1axg
Related UniProtKB
[56]
Resource
Comments
Medline ID
PubMed ID 9521768
Journal Biochemistry
Year 1998
Volume 37
Pages 4482-9
Authors Cho H, Plapp BV
Title Specificity of alcohol dehydrogenases for sulfoxides.
Related PDB
Related UniProtKB
[57]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 9649310
Journal Biochemistry
Year 1998
Volume 37
Pages 9295-304
Authors Colby TD, Bahnson BJ, Chin JK, Klinman JP, Goldstein BM
Title Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Related PDB 1a71 1a72
Related UniProtKB
[58]
Resource
Comments
Medline ID
PubMed ID 9485460
Journal Biochemistry
Year 1998
Volume 37
Pages 3068-77
Authors Piersma SR, Visser AJ, de Vries S, Duine JA
Title Optical spectroscopy of nicotinoprotein alcohol dehydrogenase from Amycolatopsis methanolica: a comparison with horse liver alcohol dehydrogenase and UDP-galactose epimerase.
Related PDB
Related UniProtKB
[59]
Resource
Comments
Medline ID
PubMed ID 9572895
Journal J Med Chem
Year 1998
Volume 41
Pages 1696-701
Authors Schindler JF, Berst KB, Plapp BV
Title Inhibition of human alcohol dehydrogenases by formamides.
Related PDB
Related UniProtKB
[60]
Resource
Comments
Medline ID
PubMed ID 10352708
Journal Adv Exp Med Biol
Year 1999
Volume 463
Pages 373-7
Authors Persson B, Nordling E, Kallberg Y, Lundh D, Oppermann UC, Marschall HU, Jornvall H
Title Bioinformatics in studies of SDR and MDR enzymes.
Related PDB
Related UniProtKB
[61]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 10529241
Journal Biochemistry
Year 1999
Volume 38
Pages 13951-9
Authors Ramaswamy S, Park DH, Plapp BV
Title Substitutions in a flexible loop of horse liver alcohol dehydrogenase hinder the conformational change and unmask hydrogen transfer.
Related PDB 1qlh 1qlj
Related UniProtKB
[62]
Resource
Comments
Medline ID
PubMed ID 10407146
Journal Biochim Biophys Acta
Year 1999
Volume 1432
Pages 239-50
Authors Foglio MH, Duester G
Title Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis.
Related PDB
Related UniProtKB
[63]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11041853
Journal Biochemistry
Year 2000
Volume 39
Pages 12885-97
Authors Adolph HW, Zwart P, Meijers R, Hubatsch I, Kiefer M, Lamzin V, Cedergren-Zeppezauer E
Title Structural basis for substrate specificity differences of horse liver alcohol dehydrogenase isozymes.
Related PDB 1ee2
Related UniProtKB
[64]
Resource
Comments Theoretical model
Medline ID
PubMed ID 10733557
Journal Hepatology
Year 2000
Volume 31
Pages 990-6
Authors Marschall HU, Oppermann UC, Svensson S, Nordling E, Persson B, Hoog JO, Jornvall H
Title Human liver class I alcohol dehydrogenase gammagamma isozyme: the sole cytosolic 3beta-hydroxysteroid dehydrogenase of iso bile acids.
Related PDB 1dda
Related UniProtKB
[65]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11601993
Journal Biochemistry
Year 2001
Volume 40
Pages 12686-94
Authors Rubach JK, Ramaswamy S, Plapp BV
Title Contributions of valine-292 in the nicotinamide binding site of liver alcohol dehydrogenase and dynamics to catalysis.
Related PDB 1ju9
Related UniProtKB
[66]
Resource
Comments
Medline ID
PubMed ID 11724603
Journal J Am Chem Soc
Year 2001
Volume 123
Pages 11952-9
Authors Luo J, Bruice TC
Title Dynamic structures of horse liver alcohol dehydrogenase (HLADH): results of molecular dynamics simulations of HLADH-NAD(+)-PhCH(2)OH, HLADH-NAD(+)-PhCH(2)O(-), and HLADH-NADH-PhCHO.
Related PDB
Related UniProtKB
[67]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11134046
Journal J Biol Chem
Year 2001
Volume 276
Pages 9316-21
Authors Meijers R, Morris RJ, Adolph HW, Merli A, Lamzin VS, Cedergren-Zeppezauer ES
Title On the enzymatic activation of NADH.
Related PDB 1het 1heu
Related UniProtKB
[68]
Resource
Comments
Medline ID
PubMed ID 11173978
Journal J Biomed Sci
Year 2001
Volume 8
Pages 71-6
Authors Hoog JO, Hedberg JJ, Stromberg P, Svensson S
Title Mammalian alcohol dehydrogenase - functional and structural implications.
Related PDB
Related UniProtKB
[69]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11274460
Journal Protein Sci
Year 2001
Volume 10
Pages 697-706
Authors Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD
Title Three-dimensional structures of the three human class I alcohol dehydrogenases.
Related PDB 1hso 1hsz 1ht0
Related UniProtKB
[70]
Resource
Comments
Medline ID
PubMed ID 12491384
Journal Angew Chem Int Ed Engl
Year 2002
Volume 41
Pages 478-81
Authors Lo HC, Fish RH
Title Biomimetic NAD(+) models for tandem cofactor regeneration, horse liver alcohol dehydrogenase recognition of 1,4-NADH derivatives, and chiral synthesis.
Related PDB
Related UniProtKB
[71]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12501206
Journal Biochemistry
Year 2002
Volume 41
Pages 15770-9
Authors Rubach JK, Plapp BV
Title Mobility of fluorobenzyl alcohols bound to liver alcohol dehydrogenases as determined by NMR and X-ray crystallographic studies.
Related PDB 1mg0 1mgo
Related UniProtKB
[72]
Resource
Comments
Medline ID
PubMed ID 11916410
Journal J Am Chem Soc
Year 2002
Volume 124
Pages 3270-6
Authors Caratzoulas S, Mincer JS, Schwartz SD
Title Identification of a protein-promoting vibration in the reaction catalyzed by horse liver alcohol dehydrogenase.
Related PDB
Related UniProtKB
[73]
Resource
Comments
Medline ID
PubMed ID 11942822
Journal J Am Chem Soc
Year 2002
Volume 124
Pages 3858-64
Authors Kohen A, Jensen JH
Title Boundary conditions for the Swain-Schaad relationship as a criterion for hydrogen tunneling.
Related PDB
Related UniProtKB
[74]
Resource
Comments
Medline ID
PubMed ID 12481026
Journal Proc Natl Acad Sci U S A
Year 2002
Volume 99
Pages 16597-600
Authors Luo J, Bruice TC
Title Ten-nanosecond molecular dynamics simulation of the motions of the horse liver alcohol dehydrogenase.PhCH2O- complex.
Related PDB
Related UniProtKB
[75]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12627956
Journal Biochemistry
Year 2003
Volume 42
Pages 2907-15
Authors Rubach JK, Plapp BV
Title Amino acid residues in the nicotinamide binding site contribute to catalysis by horse liver alcohol dehydrogenase.
Related PDB 1n8k 1n92
Related UniProtKB
[76]
Resource
Comments
Medline ID
PubMed ID 14523561
Journal Cell Mol Life Sci
Year 2003
Volume 60
Pages 2009-16
Authors Hjelmqvist L, Norin A, El-Ahmad M, Griffiths W, Jornvall H
Title Distinct but parallel evolutionary patterns between alcohol and aldehyde dehydrogenases: addition of fish/human betaine aldehyde dehydrogenase divergence.
Related PDB
Related UniProtKB
[77]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12855684
Journal J Biol Chem
Year 2003
Volume 278
Pages 36699-706
Authors Venkataramaiah TH, Plapp BV
Title Formamides mimic aldehydes and inhibit liver alcohol dehydrogenases and ethanol metabolism.
Related PDB 1p1r
Related UniProtKB
[78]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 15023053
Journal Biochemistry
Year 2004
Volume 43
Pages 3014-26
Authors LeBrun LA, Park DH, Ramaswamy S, Plapp BV
Title Participation of histidine-51 in catalysis by horse liver alcohol dehydrogenase.
Related PDB 1qv6 1qv7
Related UniProtKB
[79]
Resource
Comments
Medline ID
PubMed ID 15331786
Journal Proc Natl Acad Sci U S A
Year 2004
Volume 101
Pages 13152-6
Authors Luo J, Bruice TC
Title Anticorrelated motions as a driving force in enzyme catalysis: the dehydrogenase reaction.
Related PDB
Related UniProtKB

Comments
This enzyme is structurally similar to class III of zinc-containing alcohol dehydrogenase superfamily.
Although this enzyme binds two zinc ions, only one zinc ion is involved in catalysis.

Created Updated
2005-01-11 2009-02-26