DB code: M00007

CATH domain 3.40.50.740 : Rossmann fold
3.40.228.10 : Dimethylsulfoxide Reductase; domain 2 Catalytic domain
3.90.55.10 : Dimethylsulfoxide Reductase; domain 3
2.40.40.20 : Barwin-like endoglucanases
E.C. 1.7.2.3
CSA 1tmo
M-CSA 1tmo
MACiE

CATH domain Related DB codes (homologues)
2.40.40.20 : Barwin-like endoglucanases S00101

Uniprot Enzyme Name
UniprotKB Protein name Synonyms Pfam
O87948 Trimethylamine-N-oxide reductase
TMAO reductase
Trimethylamine oxidase
EC 1.7.2.3
PF00384 (Molybdopterin)
PF01568 (Molydop_binding)
[Graphical View]

KEGG enzyme name
trimethylamine-N-oxide reductase (cytochrome c)
TMAO reductase
TOR

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
O87948 TORA_SHEMA Trimethylamine + 2 (ferricytochrome c)-subunit + H(2)O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H(+). Periplasm.

KEGG Pathways
Map code Pathways E.C.

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00150 C00126 C01104 C00080 C00125 C00565 C00001
E.C.
Compound Molybdenum Ferrocytochrome c Trimethylamine N-oxide H+ Ferricytochrome c Trimethylamine H2O
Type heavy metal amide group,amine group,aromatic ring (with nitrogen atoms),carboxyl group,heavy metal,sulfide group amine group others amide group,amine group,aromatic ring (with nitrogen atoms),carboxyl group,heavy metal,sulfide group amine group H2O
ChEBI 28685
15724
15378
18139
15377
PubChem 23932
1145
1038
1146
22247451
962
1tmoA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
1tmoA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2MO Unbound Unbound Unbound Unbound
1tmoA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
1tmoA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
PDB;1tmo

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1tmoA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1tmoA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 149 (Molybdenum binding)
1tmoA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1tmoA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain

References for Catalytic Mechanism
References Sections No. of steps in catalysis

References
[1]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
Medline ID 99033057
PubMed ID 9813128
Journal J Mol Biol
Year 1998
Volume 284
Pages 435-47
Authors Czjzek M, Dos Santos JP, Pommier J, Giordano G, Mejean V, Haser R
Title Crystal structure of oxidized trimethylamine N-oxide reductase from Shewanella massilia at 2.5 A resolution.
Related PDB 1tmo
Related UniProtKB O87948
[2]
Resource
Comments
Medline ID
PubMed ID 11781311
Journal J Biol Chem
Year 2002
Volume 277
Pages 10362-6
Authors Allen SC, Barrett CM, Ray N, Robinson C
Title Essential cytoplasmic domains in the Escherichia coli TatC protein.
Related PDB
Related UniProtKB

Comments

Created Updated
2004-03-25 2009-02-26