DB code: M00017

CATH domain 3.40.120.10 : Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Catalytic domain
3.40.120.10 : Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Catalytic domain
3.40.120.10 : Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Catalytic domain
3.30.310.50 : TATA-Binding Protein
E.C. 5.4.2.2
CSA
M-CSA
MACiE

CATH domain Related DB codes (homologues)

Uniprot Enzyme Name
UniprotKB Protein name Synonyms RefSeq Pfam
P00949 Phosphoglucomutase-1
PGM 1
EC 5.4.2.2
Glucose phosphomutase 1
NP_001075785.1 (Protein)
NM_001082316.1 (DNA/RNA sequence)
PF02878 (PGM_PMM_I)
PF02879 (PGM_PMM_II)
PF02880 (PGM_PMM_III)
PF00408 (PGM_PMM_IV)
[Graphical View]
P47244 Phosphoglucomutase-1
PGM 1
EC 5.4.2.2
Glucose phosphomutase 1
Parafusin
Pf
pp63
XP_001429571.1 (Protein)
XM_001429534.1 (DNA/RNA sequence)
PF02878 (PGM_PMM_I)
PF02879 (PGM_PMM_II)
PF02880 (PGM_PMM_III)
PF00408 (PGM_PMM_IV)
[Graphical View]

KEGG enzyme name
phosphoglucomutase
glucose phosphomutase
phosphoglucose mutase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P00949 PGM1_RABIT Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. Monomer. Isoform 1: Cytoplasm. Isoform 2: Sarcoplasmic reticulum. Note=Localizes to the junctional skeletal sarcoplasmic reticulum, probably by association with phospholipids and/or other proteins. Binds 1 magnesium ion per subunit.
P47244 PGM1_PARTE Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. Cytoplasm. Binds 1 magnesium ion per subunit.

KEGG Pathways
Map code Pathways E.C.
MAP00010 Glycolysis / Gluconeogenesis
MAP00030 Pentose phosphate pathway
MAP00052 Galactose metabolism
MAP00500 Starch and sucrose metabolism
MAP00521 Streptomycin biosynthesis

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00305 C00103 C00620 C01171 C00668 C03736 C03735 C00660
E.C.
Compound Magnesium alpha-D-Glucose 1-phosphate alpha-D-Ribose 1-phosphate alpha-D-Hexose 1-phosphate alpha-D-Glucose 6-phosphate alpha-D-Ribose 5-phosphate alpha-D-Hexose 6-phosphate D-Glucose 1,6-bisphosphate Transition from Ser to 6-OH
Type divalent metal (Ca2+, Mg2+) carbohydrate,phosphate group/phosphate ion carbohydrate,phosphate group/phosphate ion carbohydrate,phosphate group/phosphate ion carbohydrate,phosphate group/phosphate ion carbohydrate,phosphate group/phosphate ion carbohydrate,phosphate group/phosphate ion
ChEBI 18420
29042
16300
16326
17665
18189
PubChem 888
65533
439236
439426
439284
440101
440100
1c47A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c47B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c4gA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c4gB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jdyA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jdyB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lxtA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lxtB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1vklA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1vklB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2pmgA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2pmgB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3pmgA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3pmgB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfiA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfiB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfqA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfqB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c47A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CD Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c47B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CD Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c4gA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CO Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c4gB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jdyA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CD Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jdyB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CD Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lxtA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CD Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lxtB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CD Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1vklA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NI Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1vklB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NI Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2pmgA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2pmgB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3pmgA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3pmgB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfiA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_ZN Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfiB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_ZN Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfqA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfqB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CA Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c47A03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-bound:G16 Unbound
1c47B03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c4gA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:VG1
1c4gB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jdyA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jdyB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lxtA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lxtB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1vklA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1vklB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2pmgA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2pmgB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3pmgA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3pmgB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfiA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfiB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfqA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfqB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c47A04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c47B04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c4gA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1c4gB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jdyA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:SO4 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jdyB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:SO4 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lxtA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lxtB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1vklA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1vklB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2pmgA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2pmgB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3pmgA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3pmgB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfiA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:SO4 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfiB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:SO4 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfqA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1kfqB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
literature [14], [16], [17]

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1c47A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22;SER 116;HIS 117;LYS 129 SER 116(Magnesium binding)
1c47B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22;SER 116;HIS 117;LYS 129 SER 116(Magnesium binding)
1c4gA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22;SER 116;HIS 117;LYS 129 SER 116(Magnesium binding)
1c4gB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22;SER 116;HIS 117;LYS 129 SER 116(Magnesium binding)
1jdyA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22; ;HIS 117;LYS 129 SEP 116(Magnesium binding) SEP 116(Phosphonoserine)
1jdyB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22; ;HIS 117;LYS 129 SEP 116(Magnesium binding) SEP 116(Phosphonoserine)
1lxtA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22;SER 116;HIS 117;LYS 129 SER 116(Magnesium binding)
1lxtB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22;SER 116;HIS 117;LYS 129 SER 116(Magnesium binding)
1vklA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22; ;HIS 117;LYS 129 SER 116(Magnesium binding) SEP 116(Phosphonoserine)
1vklB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22; ;HIS 117;LYS 129 SER 116(Magnesium binding) SEP 116(Phosphonoserine)
2pmgA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22;SER 116;HIS 117;LYS 129 SER 116(Magnesium binding)
2pmgB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22;SER 116;HIS 117;LYS 129 SER 116(Magnesium binding)
3pmgA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22;SER 116;HIS 117;LYS 129 SER 116(Magnesium binding) SEP 116(Phosphorylation)
3pmgB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 22;SER 116;HIS 117;LYS 129 SER 116(Magnesium binding) SEP 116(Phosphorylation)
1kfiA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 27;SER 126;HIS 127;LYS 140 SER 126(Magnesium binding) SER 126(Phosphorylation)
1kfiB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 27;SER 126;HIS 127;LYS 140 SER 126(Magnesium binding) SER 126(Phosphorylation)
1kfqA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 27;SER 126;HIS 127;LYS 140 SER 126(Magnesium binding) SER 126(Phosphorylation)
1kfqB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 27;SER 126;HIS 127;LYS 140 SER 126(Magnesium binding) SER 126(Phosphorylation)
1c47A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
1c47B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
1c4gA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
1c4gB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
1jdyA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
1jdyB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
1lxtA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
1lxtB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
1vklA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
1vklB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
2pmgA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
2pmgB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
3pmgA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
3pmgB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 292 ASP 287;ASP 289;ASP 291(Magnesium binding)
1kfiA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 313 ASP 308;ASP 310;ASP 312(Magnesium binding)
1kfiB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 313 ASP 308;ASP 310;ASP 312(Magnesium binding)
1kfqA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 313 ASP 308;ASP 310;ASP 312(Magnesium binding)
1kfqB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 313 ASP 308;ASP 310;ASP 312(Magnesium binding)
1c47A03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
1c47B03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
1c4gA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
1c4gB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
1jdyA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
1jdyB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
1lxtA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
1lxtB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
1vklA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
1vklB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
2pmgA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
2pmgB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
3pmgA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
3pmgB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 388
1kfiA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 405
1kfiB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 405
1kfqA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 405
1kfqB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 405
1c47A04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1c47B04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1c4gA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1c4gB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1jdyA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1jdyB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lxtA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lxtB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1vklA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1vklB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2pmgA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2pmgB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3pmgA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3pmgB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1kfiA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1kfiB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1kfqA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1kfqB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[9]
Scheme II, p.504
[10]
p.511-512
[11]
p.6328-6329
[12]
p.52-55
[14]
p.404-405
[16]
p.148
[17]
Fig.5, p.275-277
[18]
Chart 1, p.9948-9950
[19]
Fig.1, p.60-61

References
[1]
Resource
Comments ACTIVE SITE
Medline ID 68368401
PubMed ID 5669853
Journal Biochem J
Year 1968
Volume 109
Pages 93-9
Authors Milstein CP, Milstein C
Title A tryptic peptide containing a unique serine phosphate residue in rabbit phosphoglucomutase.
Related PDB
Related UniProtKB P00949
[2]
Resource
Comments
Medline ID
PubMed ID 5041899
Journal Biochemistry
Year 1972
Volume 11
Pages 2800-4
Authors Ray WJ Jr, Goodin DS, Ng L
Title Cobalt (II) and nickel (II) complexes of phosphoglucomutase.
Related PDB
Related UniProtKB
[3]
Resource
Comments
Medline ID
PubMed ID 4830239
Journal J Biol Chem
Year 1974
Volume 249
Pages 3166-9
Authors Walinder O, Joshi JG
Title Mechanism of action of rabbit muscle phosphoglucomutase. Rate of enzyme phosphate turnover studied with a rapid mixing technique.
Related PDB
Related UniProtKB
[4]
Resource
Comments
Medline ID
PubMed ID 6115419
Journal Philos Trans R Soc Lond B Biol Sci
Year 1981
Volume 293
Pages 205-8
Authors Wierenga RK, Lewis DG, Rossmann MG, Ray WJ Jr
Title The structure determination of rabbit phosphoglucomutase.
Related PDB
Related UniProtKB
[5]
Resource
Comments
Medline ID
PubMed ID 2934384
Journal J Biol Chem
Year 1986
Volume 261
Pages 264-74
Authors Lin Z, Konno M, Abad-Zapatero C, Wierenga R, Murthy MR, Ray WJ Jr, Rossmann MG
Title The structure of rabbit muscle phosphoglucomutase at intermediate resolution.
Related PDB
Related UniProtKB
[6]
Resource
Comments
Medline ID
PubMed ID 2974722
Journal Biochemistry
Year 1988
Volume 27
Pages 7328-32
Authors Kim SC, Raushel FM
Title Mechanism-based inactivation of rabbit muscle phosphoglucomutase by nojirimycin 6-phosphate.
Related PDB
Related UniProtKB
[7]
Resource
Comments
Medline ID
PubMed ID 1712631
Journal Biochemistry
Year 1991
Volume 30
Pages 6866-75
Authors Ray WJ Jr, Bolin JT, Puvathingal JM, Minor W, Liu YW, Muchmore SW
Title Removal of salt from a salt-induced protein crystal without cross-linking. Preliminary examination of "desalted" crystals of phosphoglucomutase by X-ray crystallography at low temperature.
Related PDB
Related UniProtKB
[8]
Resource
Comments
Medline ID
PubMed ID 1829964
Journal Biochemistry
Year 1991
Volume 30
Pages 6875-85
Authors Ray WJ Jr, Puvathingal JM, Liu YW
Title Formation of substrate and transition-state analogue complexes in crystals of phosphoglucomutase after removing the crystallization salt.
Related PDB
Related UniProtKB
[9]
Resource
Comments
Medline ID
PubMed ID 1531025
Journal Biochemistry
Year 1992
Volume 31
Pages 498-505
Authors Percival MD, Withers SG
Title Binding energy and catalysis: deoxyfluoro sugars as probes of hydrogen bonding in phosphoglucomutase.
Related PDB
Related UniProtKB
[10]
Resource
Comments
Medline ID
PubMed ID 1531026
Journal Biochemistry
Year 1992
Volume 31
Pages 505-12
Authors Percival MD, Withers SG
Title 19F NMR investigations of the catalytic mechanism of phosphoglucomutase using fluorinated substrates and inhibitors.
Related PDB
Related UniProtKB
[11]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS)
Medline ID 92210613
PubMed ID 1532581
Journal J Biol Chem
Year 1992
Volume 267
Pages 6322-37
Authors Dai JB, Liu Y, Ray WJ Jr, Konno M
Title The crystal structure of muscle phosphoglucomutase refined at 2.7-angstrom resolution.
Related PDB 2pmg
Related UniProtKB P00949
[12]
Resource
Comments
Medline ID
PubMed ID 8418859
Journal Biochemistry
Year 1993
Volume 32
Pages 48-57
Authors Ray WJ Jr, Post CB, Liu Y, Rhyu GI
Title Structural changes at the metal ion binding site during the phosphoglucomutase reaction.
Related PDB
Related UniProtKB
[13]
Resource
Comments
Medline ID
PubMed ID 8418857
Journal Biochemistry
Year 1993
Volume 32
Pages 38-47
Authors Ray WJ Jr, Post CB, Puvathingal JM
Title Reaction of the isosteric methylenephosphonate analog of alpha-D-glucose 1-phosphate with phosphoglucomutase. Induced-fit specificity revisited.
Related PDB
Related UniProtKB
[14]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)
Medline ID
PubMed ID 15299905
Journal Acta Crystallogr D Biol Crystallogr
Year 1997
Volume 53
Pages 392-405
Authors Liu Y, Ray WJ Jr, Baranidharan S
Title Structure of rabbit muscle phosphoglucomutase refined at 2.4-A
Related PDB 1lxt
Related UniProtKB P00949
[15]
Resource
Comments
Medline ID
PubMed ID 10506283
Journal Protein Eng
Year 1999
Volume 12
Pages 737-46
Authors Levin S, Almo SC, Satir BH
Title Functional diversity of the phosphoglucomutase superfamily: structural implications.
Related PDB
Related UniProtKB
[16]
Resource
Comments
Medline ID
PubMed ID 11779235
Journal J Mol Biol
Year 2002
Volume 315
Pages 141-53
Authors Muller S, Diederichs K, Breed J, Kissmehl R, Hauser K, Plattner H, Welte W
Title Crystal structure analysis of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase), from Paramecium reveals significant conformational variability.
Related PDB 1kfi 1kfq
Related UniProtKB P47244
[17]
Resource
Comments
Medline ID
PubMed ID 11839312
Journal Structure (Camb)
Year 2002
Volume 10
Pages 269-79
Authors Regni C, Tipton PA, Beamer LJ
Title Crystal structure of PMM/PGM: an enzyme in the biosynthetic pathway of P. aeruginosa virulence factors.
Related PDB
Related UniProtKB
[18]
Resource
Comments
Medline ID
PubMed ID 12924943
Journal Biochemistry
Year 2003
Volume 42
Pages 9946-51
Authors Naught LE, Regni C, Beamer LJ, Tipton PA
Title Roles of active site residues in Pseudomonas aeruginosa phosphomannomutase/phosphoglucomutase.
Related PDB
Related UniProtKB
[19]
Resource
Comments
Medline ID
PubMed ID 14725765
Journal Structure (Camb)
Year 2004
Volume 12
Pages 55-63
Authors Regni C, Naught L, Tipton PA, Beamer LJ
Title Structural basis of diverse substrate recognition by the enzyme PMM/PGM from P. aeruginosa.
Related PDB
Related UniProtKB

Comments
This enzyme catalyzes two phosphoryl transfer reactions as follows:
(A) Transfer of phosphoryl group from hydroxyl group of Ser116 to 6-OH of glucose-1-phosphate, forming glucose-1,6-diphosphate:
(B) Transfer of phosphoryl group from 1-OH of a glucose-1,6-diphosphate intermediate to Ser:

Created Updated
2005-06-10 2009-02-26