DB code: M00103

CATH domain 3.30.457.10 : Copper Amine Oxidase; Chain A, domain 1
3.10.450.40 : Nuclear Transport Factor 2; Chain
2.70.98.20 : Beta-galactosidase; Chain A, domain 5 Catalytic domain
3.10.450.40 : Nuclear Transport Factor 2; Chain
E.C. 1.4.3.21
CSA 1oac
M-CSA 1oac
MACiE

CATH domain Related DB codes (homologues)
2.70.98.20 : Beta-galactosidase; Chain A, domain 5 M00202 T00206 T00250 T00251
3.10.450.40 : Nuclear Transport Factor 2; Chain M00202 T00206 T00250 T00251

Uniprot Enzyme Name
UniprotKB Protein name Synonyms RefSeq Pfam
P46883 Primary amine oxidase
EC 1.4.3.21
2-phenylethylamine oxidase
Copper amine oxidase
Tyramine oxidase
NP_415904.3 (Protein)
NC_000913.2 (DNA/RNA sequence)
YP_489655.1 (Protein)
NC_007779.1 (DNA/RNA sequence)
PF01179 (Cu_amine_oxid)
PF07833 (Cu_amine_oxidN1)
PF02727 (Cu_amine_oxidN2)
PF02728 (Cu_amine_oxidN3)
[Graphical View]

KEGG enzyme name
primary-amine oxidase
amine oxidase (ambiguous)
amine oxidase (copper-containing)
amine oxidase (pyridoxal containing) (incorrect)
benzylamine oxidase (incorrect)
CAO (ambiguous)
copper amine oxidase (ambiguous)
Cu-amine oxidase (ambiguous)
Cu-containing amine oxidase (ambiguous)
diamine oxidase (incorrect)
diamino oxhydrase (incorrect)
histamine deaminase (ambiguous)
histamine oxidase (ambiguous)
monoamine oxidase (ambiguous)
plasma monoamine oxidase (ambiguous)
polyamine oxidase (ambiguous)
semicarbazide-sensitive amine oxidase (ambiguous)
SSAO (ambiguous)

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P46883 AMO_ECOLI 2-phenylethylamine + H(2)O + O(2) = phenylacetaldehyde + NH(3) + H(2)O(2). RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2). Homodimer. Periplasm. Binds 1 copper ion per subunit. Binds 2 calcium ions per subunit. Contains 1 topaquinone per subunit.

KEGG Pathways
Map code Pathways E.C.
MAP00260 Glycine, serine and threonine metabolism
MAP00350 Tyrosine metabolism
MAP00360 Phenylalanine metabolism
MAP00410 beta-Alanine metabolism
MAP00960 Alkaloid biosynthesis II

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00070 C00076 L00003 C00375 C00001 C00007 C00071 C00014 C00027 I00021 I00022 I00023 I00024
E.C.
Compound Copper Calcium Topaquinone RCH2NH2 H2O Oxygen Aldehyde NH3 H2O2 Substrate Schiff-base (Iminoquinone=substrate) Carbanionic intermediate Product Schiff-base (Aminoquinol=product) Aminoquinol/Semiquinone Iminoquinone
Type heavy metal divalent metal (Ca2+, Mg2+) amino acids,aromatic ring (only carbon atom) amine group H2O others carbohydrate amine group,organic ion others
ChEBI 28694
30052
29108
36077
68431
15377
15379
26689
27140
16134
16240
PubChem 23978
271
22247451
962
977
222
22326046
784
1d6uA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6uB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6yA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6yB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6zA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6zB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jrqA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jrqB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lvnA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lvnB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1oacA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1oacB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1spuA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1spuB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1dyuA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1dyuB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qafA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qafB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qakA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qakB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qalA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qalB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6uA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6uB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6yA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6yB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6zA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6zB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jrqA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jrqB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lvnA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lvnB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1oacA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1oacB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1spuA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1spuB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1dyuA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1dyuB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qafA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qafB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qakA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qakB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qalA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qalB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6uA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Analogue:TYQ_466 Unbound Unbound Bound:HY1 Unbound Unbound Unbound Unbound Unbound Intermediate-bound:TYQ_466 Unbound
1d6uB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Analogue:TYQ_466 Unbound Unbound Bound:HY1 Unbound Unbound Unbound Unbound Unbound Intermediate-bound:TYQ_466 Unbound
1d6yA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Analogue:TYQ_466 Unbound Analogue:_NO Bound:HY1 Unbound Unbound Unbound Unbound Unbound Intermediate-bound:TYQ_466 Unbound
1d6yB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Analogue:TYQ_466 Unbound Analogue:_NO Bound:HY1 Unbound Unbound Unbound Unbound Unbound Intermediate-bound:TYQ_466 Unbound
1d6zA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Analogue:TYY_466 Unbound Unbound Bound:HY1 Unbound Bound:PEO Unbound Unbound Unbound Unbound Intermediate-bound:TYY_466
1d6zB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Analogue:TYY_466 Unbound Unbound Bound:HY1 Unbound Bound:PEO Unbound Unbound Unbound Unbound Intermediate-bound:TYY_466
1jrqA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jrqB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lvnA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Analogue:TYT_466 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:TYT_466 Unbound Unbound Unbound Unbound
1lvnB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Analogue:TYT_466 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:TYT_466 Unbound Unbound Unbound Unbound
1oacA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1oacB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1spuA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Analogue:PAQ_466 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PAQ_466 Unbound Unbound Unbound Unbound
1spuB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Analogue:PAQ_466 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PAQ_466 Unbound Unbound Unbound Unbound
1dyuA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1dyuB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qafA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qafB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Analogue:GOL Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qakA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qakB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qalA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qalB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_CU Bound:2x_CA Bound:TPQ_466 Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6uA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6uB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6yA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6yB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6zA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1d6zB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jrqA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1jrqB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lvnA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1lvnB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1oacA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1oacB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1spuA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1spuB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1dyuA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1dyuB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qafA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qafB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qakA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qakB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qalA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qalB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1d6uA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6uB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6yA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6yB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6zA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6zB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1jrqA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1jrqB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lvnA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lvnB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1oacA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1oacB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1spuA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1spuB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1dyuA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1dyuB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qafA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qafB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qakA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qakB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qalA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qalB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6uA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6uB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6yA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6yB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6zA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6zB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1jrqA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1jrqB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lvnA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lvnB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1oacA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1oacB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1spuA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1spuB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1dyuA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1dyuB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qafA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qafB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qakA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qakB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qalA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qalB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6uA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TYQ 466(aminoquinol)
1d6uB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TYQ 466(aminoquinol)
1d6yA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TYQ 466(aminoquinol)
1d6yB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TYQ 466(aminoquinol)
1d6zA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TYY 466(iminoquinone)
1d6zB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TYY 466(iminoquinone)
1jrqA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TPQ 466(topaquinone) mutant Y369F
1jrqB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TPQ 466(topaquinone) mutant Y369F
1lvnA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TYT 466(iminoquinone-substrate analogue)
1lvnB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TYT 466(iminoquinone-substrate analogue)
1oacA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TPQ 466(topaquinone)
1oacB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TPQ 466(topaquinone)
1spuA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) PAQ 466(2-oxy-4-hydroxy-5-(2-hydrazinopyridine)phenylalanine)
1spuB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) PAQ 466(2-oxy-4-hydroxy-5-(2-hydrazinopyridine)phenylalanine)
1dyuA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TYR 466(topaquinone)
1dyuB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369;ASP 383 HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TYR 466(topaquinone)
1qafA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369; HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TPQ 466(topaquinone) mutant D383E
1qafB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369; HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TPQ 466(topaquinone) mutant D383E
1qakA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369; HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TPQ 466(topaquinone) mutant D383A
1qakB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369; HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TPQ 466(topaquinone) mutant D383A
1qalA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369; HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TPQ 466(topaquinone) mutant D383N
1qalB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain TYR 369; HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) TPQ 466(topaquinone) mutant D383N
1d6uA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6uB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6yA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6yB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6zA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1d6zB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1jrqA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1jrqB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lvnA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lvnB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1oacA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1oacB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1spuA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1spuB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1dyuA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1dyuB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qafA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qafB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qakA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qakB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qalA04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1qalB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[5]
Scheme II, p.60-62
[6]
Fig. 1, p.1128-1129
[7]
Fig.1, p.1178-1179
[9]
Scheme 1, p.5586-5588
[10]
Fig.2, Fig.10, p.1617-1619
[11]
Scheme 23, Scheme 24, p.746-747
[12]
Fig.1, p.8224-8226
[13]
Fig.2, p.1725-1728
[15]
Fig.2, p.12814-12817
[17]
Scheme 1, Fig.1, p.4694-4605
[18]
Scheme 1, p.814-815
[21]
Fig.4, Fig.6, p.313-315
[22]
Scheme 1, Fig.1, p.494-496
[23]
Scheme 2

References
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Medline ID
PubMed ID 8155661
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Year 1994
Volume 33
Pages 4425-31
Authors Bossa M, Morpurgo GO, Morpurgo L
Title Models and molecular orbital semiempirical calculations in the study of the spectroscopic properties of bovine serum amine oxidase quinone cofactor.
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Related UniProtKB
[2]
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Comments
Medline ID
PubMed ID 8176752
Journal J Mol Biol
Year 1994
Volume 238
Pages 635-7
Authors Roh JH, Suzuki H, Kumagai H, Yamashita M, Azakami H, Murooka Y, Mikami B
Title Crystallization and preliminary X-ray analysis of copper amine oxidase from Escherichia coli K-12.
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Related UniProtKB
[3]
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Comments
Medline ID
PubMed ID 8585612
Journal Anal Biochem
Year 1995
Volume 230
Pages 159-66
Authors Steinebach V, Groen BW, Wijmenga SS, Niessen WM, Jongejan JA, Duine JA
Title Identification of topaquinone, as illustrated for pig kidney diamine oxidase and Escherichia coli amine oxidase.
Related PDB
Related UniProtKB
[4]
Resource
Comments
Medline ID
PubMed ID 7766611
Journal Biochemistry
Year 1995
Volume 34
Pages 7020-6
Authors Moenne-Loccoz P, Nakamura N, Steinebach V, Duine JA, Mure M, Klinman JP, Sanders-Loehr J
Title Characterization of the topa quinone cofactor in amine oxidase from Escherichia coli by resonance Raman spectroscopy.
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Related UniProtKB
[5]
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Comments
Medline ID
PubMed ID 8524164
Journal Methods Enzymol
Year 1995
Volume 258
Pages 53-69
Authors Sayre LM, Lee Y
Title Catalytic aerobic deamination of activated primary amines by a model for the quinone cofactor of mammalian copper amine oxidases.
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Related UniProtKB
[6]
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Comments
Medline ID
PubMed ID 8591022
Journal Structure
Year 1995
Volume 3
Pages 1127-9
Authors Fontecave M, Eklund H
Title Copper amine oxidase: a novel use for a tyrosine.
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Related UniProtKB
[7]
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Comments X-ray crystallography
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PubMed ID 8591028
Journal Structure
Year 1995
Volume 3
Pages 1171-84
Authors Parsons MR, Convery MA, Wilmot CM, Yadav KD, Blakeley V, Corner AS, Phillips SE, McPherson MJ, Knowles PF
Title Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 A resolution.
Related PDB 1oac
Related UniProtKB
[8]
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Medline ID
PubMed ID 8706668
Journal Eur J Biochem
Year 1996
Volume 238
Pages 683-9
Authors Steinebach V, De Jong GA, Wijmenga SS, De Vries S, Duine JA
Title The copper-topaquinone-phenylhydrazine-adduct geometry in Escherichia coli amine oxidase derivatized with phenylhydrazines substituted with 19F-NMR relaxation measurements.
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Related UniProtKB
[9]
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Comments
Medline ID
PubMed ID 8621418
Journal J Biol Chem
Year 1996
Volume 271
Pages 5580-8
Authors Steinebach V, de Vries S, Duine JA
Title Intermediates in the catalytic cycle of copper-quinoprotein amine oxidase from Escherichia coli.
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Related UniProtKB
[10]
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Comments X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
Medline ID 97200715
PubMed ID 9048544
Journal Biochemistry
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Authors Wilmot CM, Murray JM, Alton G, Parsons MR, Convery MA, Blakeley V, Corner AS, Palcic MM, Knowles PF, McPherson MJ, Phillips SE
Title Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction.
Related PDB 1spu
Related UniProtKB P46883
[11]
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Medline ID
PubMed ID 11848913
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Year 1998
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Related UniProtKB
[12]
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Comments X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
Medline ID 99315198
PubMed ID 10387067
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Year 1999
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Authors Murray JM, Saysell CG, Wilmot CM, Tambyrajah WS, Jaeger J, Knowles PF, Phillips SE, McPherson MJ
Title The active site base controls cofactor reactivity in Escherichia coli amine oxidase: x-ray crystallographic studies with mutational variants.
Related PDB
Related UniProtKB P46883
[13]
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Comments X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)
Medline ID 20045000
PubMed ID 10576737
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Year 1999
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Related UniProtKB P46883
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Medline ID
PubMed ID 11665487
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Title Trihydroxyphenylalanine quinone (TPQ) from copper amine oxidases and lysyl tyrosylquinone (LTQ) from lysyl oxidase.
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Related UniProtKB
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Medline ID
PubMed ID 11669617
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Related UniProtKB
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Medline ID
PubMed ID 11751046
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Related UniProtKB
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Medline ID
PubMed ID 11532005
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Related UniProtKB
[18]
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Medline ID
PubMed ID 11985492
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Year 2002
Volume 365
Pages 809-16
Authors Saysell CG, Tambyrajah WS, Murray JM, Wilmot CM, Phillips SE, McPherson MJ, Knowles PF
Title Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a substrate analogue.
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Related UniProtKB
[19]
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Comments
Medline ID
PubMed ID 11781110
Journal Biochemistry
Year 2002
Volume 41
Pages 687-96
Authors Green EL, Nakamura N, Dooley DM, Klinman JP, Sanders-Loehr J
Title Rates of oxygen and hydrogen exchange as indicators of TPQ cofactor orientation in amine oxidases.
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Related UniProtKB
[20]
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Medline ID
PubMed ID 12153561
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Year 2002
Volume 269
Pages 3645-58
Authors Shepard EM, Smith J, Elmore BO, Kuchar JA, Sayre LM, Dooley DM
Title Towards the development of selective amine oxidase inhibitors. Mechanism-based inhibition of six copper containing amine oxidases.
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Related UniProtKB
[21]
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Medline ID
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Journal Methods Enzymol
Year 2002
Volume 353
Pages 301-18
Authors Wilmot CM, Sjogren T, Carlsson GH, Berglund GI, Hajdu J
Title Defining redox state of X-ray crystal structures by single-crystal ultraviolet-visible microspectrophotometry.
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Related UniProtKB
[22]
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Medline ID
PubMed ID 12773142
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Year 2003
Volume 31
Pages 493-6
Authors Wilmot CM
Title Oxygen activation in a copper-containing amine oxidase.
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Related UniProtKB
[23]
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Medline ID
PubMed ID 15234266
Journal Arch Biochem Biophys
Year 2004
Volume 428
Pages 22-31
Authors Brazeau BJ, Johnson BJ, Wilmot CM
Title Copper-containing amine oxidases. Biogenesis and catalysis; a structural perspective.
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Related UniProtKB
[24]
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Comments
Medline ID
PubMed ID 15498552
Journal FEBS Lett
Year 2004
Volume 576
Pages 301-5
Authors Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE
Title Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine.
Related PDB 1lvn
Related UniProtKB
[25]
Resource
Comments
Medline ID
PubMed ID 15369390
Journal J Med Chem
Year 2004
Volume 47
Pages 4865-74
Authors Marti L, Abella A, De La Cruz X, Garcia-Vicente S, Unzeta M, Carpene C, Palacin M, Testar X, Orozco M, Zorzano A
Title Exploring the binding mode of semicarbazide-sensitive amine oxidase/VAP-1: identification of novel substrates with insulin-like activity.
Related PDB
Related UniProtKB

Comments
Cofactor, topaquinone (2,4,5-trihydroxyphenylalanine), is a modified residue, generated from active site tyrosine residue (Tyr466) by self-catalysis (see [6]).
Although this enzyme binds a copper ion and two calcium ions as cofactors per subunit, the calcium ions are not involved in catalysis.
The following compounds can be inculded as substrate and product, respectively:
Phenethylamine;C05332
Phenylacetaldehyde;C00601
According to the literature [13], this enzyme catalyzes two half-reactions: (I) reductive half-reaction, and (II) oxidative half-reaction. These half-reactions can be subdivided into several basic reactions in terms of RLCP classification.
(I) Reductive half-reaction:
(A) Exchange of double-bonded atoms; Schiff-base formation; Substrate amine forms a Schiff-base with topaquinone, generating iminoquinone=substrate and H2O (dehydration):
(B) Isomerization from iminoquinone=substrate complex to aminoquinol=product complex:
(C) Exchange of double-bonded atoms; Schiff-base deformation; H2O reacts with the intermediate, generating aminoquinol and product aldehyde (hydration):
(II) Oxidative half-reaction:
(D) Reduction of dioxygen (O2) by aminoquinol, to produce hydrogen peroxide (H2O2) and iminoquinone (Hydride transfer):
(E) Exchange of double-bonded atoms; Schiff-base deformation; H2O reacts with the intermediate, generating topaquinone and product ammonia (hydration):

Created Updated
2005-05-26 2009-02-26