DB code: M00151

CATH domain 1.10.620.20 : Ribonucleotide Reductase, subunit A Catalytic domain
1.10.620.20 : Ribonucleotide Reductase, subunit A
1.20.1280.10 : Monooxygenase
1.20.1280.30 : Monooxygenase
E.C. 1.14.13.25
CSA 1mhy
M-CSA 1mhy
MACiE

CATH domain Related DB codes (homologues)
1.10.620.20 : Ribonucleotide Reductase, subunit A S00028 M00204 M00205

Uniprot Enzyme Name
UniprotKB Protein name Synonyms RefSeq Pfam
P22869 Methane monooxygenase component A alpha chain
EC 1.14.13.25
Methane hydroxylase
YP_113659.1 (Protein)
NC_002977.6 (DNA/RNA sequence)
PF02332 (Phenol_Hydrox)
[Graphical View]
P27353 Methane monooxygenase component A alpha chain
EC 1.14.13.25
Methane hydroxylase
PF02332 (Phenol_Hydrox)
[Graphical View]
P18798 Methane monooxygenase component A beta chain
EC 1.14.13.25
Methane hydroxylase
YP_113660.1 (Protein)
NC_002977.6 (DNA/RNA sequence)
PF02332 (Phenol_Hydrox)
[Graphical View]
P27354 Methane monooxygenase component A beta chain
EC 1.14.13.25
Methane hydroxylase
PF02332 (Phenol_Hydrox)
[Graphical View]
P11987 Methane monooxygenase component A gamma chain
EC 1.14.13.25
Methane hydroxylase
YP_113663.1 (Protein)
NC_002977.6 (DNA/RNA sequence)
PF02964 (MeMO_Hyd_G)
[Graphical View]
P27355 Methane monooxygenase component A gamma chain
EC 1.14.13.25
Methane hydroxylase
PF02964 (MeMO_Hyd_G)
[Graphical View]

KEGG enzyme name
methane monooxygenase
methane hydroxylase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P27355 MEMG_METTR Methane + NAD(P)H + O(2) = methanol + NAD(P)(+) + H(2)O. M.trichosporium has two forms of methane monooxygenase, a soluble and a membrane-bound type. The soluble type consists of four components (A to D): protein A, comprising three chains, in an alpha-2, beta-2, gamma-2 configuration, is a nonheme iron protein containing an unusual mu-hydroxo bridge structure at its active site and interacts with both oxygen and methane.
P22869 MEMA_METCA Methane + NAD(P)H + O(2) = methanol + NAD(P)(+) + H(2)O. M.capsulatus has two forms of methane monooxygenase, a soluble and a membrane-bound type. The soluble type consists of four components (A to D): protein A, comprising three chains, in an alpha-2, beta-2, gamma-2 configuration, is a nonheme iron protein containing an unusual mu-hydroxo bridge structure at its active site and interacts with both oxygen and methane. Binds 2 iron ions.
P27353 MEMA_METTR Methane + NAD(P)H + O(2) = methanol + NAD(P)(+) + H(2)O. M.trichosporium has two forms of methane monooxygenase, a soluble and a membrane-bound type. The soluble type consists of four components (A to D): protein A, comprising three chains, in an alpha-2, beta-2, gamma-2 configuration, is a nonheme iron protein containing an unusual mu-hydroxo bridge structure at its active site and interacts with both oxygen and methane. Binds 2 iron ions.
P18798 MEMB_METCA Methane + NAD(P)H + O(2) = methanol + NAD(P)(+) + H(2)O. M.capsulatus has two forms of methane monooxygenase, a soluble and a membrane-bound type. The soluble type consists of four components (A to D): protein A, comprising three chains, in an alpha-2, beta-2, gamma-2 configuration, is a nonheme iron protein containing an unusual mu-hydroxo bridge structure at its active site and interacts with both oxygen and methane.
P27354 MEMB_METTR Methane + NAD(P)H + O(2) = methanol + NAD(P)(+) + H(2)O. M.trichosporium has two forms of methane monooxygenase, a soluble and a membrane-bound type. The soluble type consists of four components (A to D): protein A, comprising three chains, in an alpha-2, beta-2, gamma-2 configuration, is a nonheme iron protein containing an unusual mu-hydroxo bridge structure at its active site and interacts with both oxygen and methane.
P11987 MEMG_METCA Methane + NAD(P)H + O(2) = methanol + NAD(P)(+) + H(2)O. M.capsulatus has two forms of methane monooxygenase, a soluble and a membrane-bound type. The soluble type consists of four components (A to D): protein A, comprising three chains, in an alpha-2, beta-2, gamma-2 configuration, is a nonheme iron protein containing an unusual mu-hydroxo bridge structure at its active site and interacts with both oxygen and methane.

KEGG Pathways
Map code Pathways E.C.
MAP00680 Methane metabolism

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00023 C01438 C00007 C00080 C00005 C00004 C00132 C00001 C00006 C00003
E.C.
Compound Iron Methane O2 H+ NADPH NADH Methanol H2O NADP+ NAD+
Type heavy metal others others others amide group,amine group,nucleotide amide group,amine group,nucleotide carbohydrate H2O amide group,amine group,nucleotide amide group,amine group,nucleotide
ChEBI 18248
82664
16183
15379
26689
27140
15378
16474
16908
17790
15377
18009
15846
PubChem 23925
297
977
1038
5884
439153
887
22247451
962
5886
5893
1fyzA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2xFE2 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fyzB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2xFE2 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz0A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2xFE2 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz0B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2xFE2 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz1A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Analogue:FMT Unbound Unbound
1fz1B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz2A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2xFE2 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz2B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2xFE2 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz3A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Analogue:FMT Unbound Unbound
1fz3B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Analogue:FMT Unbound Unbound
1fz4B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz5A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:FE2 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz5B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:FE2 Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz7A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Analogue:FMT Unbound Unbound
1fz7B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Analogue:EOH Unbound Unbound
1mhyD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mhzD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mmoD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Analogue:ACY Unbound Unbound
1mmoE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Analogue:ACY Unbound Unbound
1mtyD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mtyE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_FE Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fyzC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fyzD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz0C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz0D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz1C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz1D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz2C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz2D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz3C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz3D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz4C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz4D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz5C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz5D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz7C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz7D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mhyB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mhzB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mmoB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mmoC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mtyB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mtyC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fyzE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fyzF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz0E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz0F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz1E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz1F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz2E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz2F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz3E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz3F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz4E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz4F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz5E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz5F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz7E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz7F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mhyG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mhzG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mmoG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mmoH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mtyG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mtyH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fyzE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fyzF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz0E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz0F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz1E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz1F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz2E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz2F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz3E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz3F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz4E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz4F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz5E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz5F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz7E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1fz7F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mhyG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mhzG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mmoG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mmoH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mtyG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1mtyH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
Swiss-prot;P22869, P27353 & literature [3], [7] & [8]

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1fyzA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fyzB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz0A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz0B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz1A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz1B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz2A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz2B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz3A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz3B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz4B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz5A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz5B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz7A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fz7B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1mhyD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1mhzD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1mmoD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1mmoE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1mtyD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1mtyE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain CYS 151;THR 213 GLU 114;GLU 144;HIS 147(Iron-1 binding);GLU 209;GLU 243;HIS 246(Iron-2 binding)
1fyzC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fyzD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz0C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz0D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz1C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz1D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz2C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz2D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz3C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz3D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz4C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz4D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz5C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz5D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz7C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz7D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mhyB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mhzB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mmoB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mmoC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mtyB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mtyC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fyzE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fyzF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz0E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz0F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz1E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz1F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz2E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz2F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz3E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz3F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz4E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz4F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz5E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz5F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz7E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz7F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mhyG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mhzG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mmoG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mmoH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mtyG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mtyH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fyzE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fyzF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz0E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz0F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz1E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz1F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz2E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz2F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz3E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz3F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz4E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz4F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz5E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz5F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz7E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1fz7F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mhyG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mhzG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mmoG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mmoH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mtyG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1mtyH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[3]
Fig.3
[4]
SCHEME 1, p.17596 4
[6]
SCHEME 1, SCHEME 2 6
[7]
p.541
[8]
Fig.6, p.412-416
[10]
Fig.1,p.65-67 5
[11]
Fig.1, Fig.8, p.5232-5233 7
[13]
Fig.1, p.560-562 7
[14]
p.143-147
[15]
Scheme 1 4
[18]
Scheme 2, Scheme 4 4
[19]
Scheme 4, p.4430-4431 3
[21]
Fig.5, p.10774-10776
[23]
Scheme 1 7
[24]
Fig.2 4
[25]
Fig.1, p.28 5
[25]
Scheme 2 4
[26]
Scheme 1 7
[28]
p.831-835
[29]
p.1795
[37]
Fig.7, p.71-73

References
[1]
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Comments
Medline ID
PubMed ID 2840063
Journal Biochem Biophys Res Commun
Year 1988
Volume 154
Pages 165-70
Authors Fox BG, Lipscomb JD
Title Purification of a high specific activity methane monooxygenase hydroxylase component from a type II methanotroph.
Related PDB
Related UniProtKB
[2]
Resource
Comments
Medline ID
PubMed ID 2542319
Journal J Biol Chem
Year 1989
Volume 264
Pages 10023-33
Authors Fox BG, Froland WA, Dege JE, Lipscomb JD
Title Methane monooxygenase from Methylosinus trichosporium OB3b. Purification and properties of a three-component system with high specific activity from a type II methanotroph.
Related PDB
Related UniProtKB
[3]
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Medline ID
PubMed ID 1644180
Journal FEBS Lett
Year 1992
Volume 307
Pages 257-62
Authors Nordlund P, Dalton H, Eklund H
Title The active site structure of methane monooxygenase is closely related to the binuclear iron center of ribonucleotide reductase.
Related PDB
Related UniProtKB
[4]
Resource
Comments
Medline ID
PubMed ID 1325441
Journal J Biol Chem
Year 1992
Volume 267
Pages 17588-97
Authors Froland WA, Andersson KK, Lee SK, Liu Y, Lipscomb JD
Title Methane monooxygenase component B and reductase alter the regioselectivity of the hydroxylase component-catalyzed reactions. A novel role for protein-protein interactions in an oxygenase mechanism.
Related PDB
Related UniProtKB
[5]
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Comments
Medline ID
PubMed ID 8223558
Journal Eur J Biochem
Year 1993
Volume 217
Pages 217-23
Authors Atta M, Fontecave M, Wilkins PC, Dalton H
Title Abduction of iron(III) from the soluble methane monooxygenase hydroxylase and reconstitution of the binuclear site with iron and manganese.
Related PDB
Related UniProtKB
[6]
Resource
Comments
Medline ID
PubMed ID 8408008
Journal J Biol Chem
Year 1993
Volume 268
Pages 21569-77
Authors Lee SK, Nesheim JC, Lipscomb JD
Title Transient intermediates of the methane monooxygenase catalytic cycle.
Related PDB
Related UniProtKB
[7]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
Medline ID 94077176
PubMed ID 8255292
Journal Nature
Year 1993
Volume 366
Pages 537-43
Authors Rosenzweig AC, Frederick CA, Lippard SJ, Nordlund P
Title Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane.
Related PDB 1mmo
Related UniProtKB P22869 P18798 P11987
[8]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
Medline ID 98092034
PubMed ID 9432288
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Year 1995
Volume 2
Pages 409-18
Authors Rosenzweig AC, Nordlund P, Takahara PM, Frederick CA, Lippard SJ
Title Geometry of the soluble methane monooxygenase catalytic diiron center in two oxidation states.
Related PDB
Related UniProtKB P22869
[9]
Resource
Comments
Medline ID
PubMed ID
Journal J Inorg Biochem
Year 1995
Volume 58
Pages 235-44
Authors Semrau JD, Zolandz D, Lidstrom ME, Chan SI
Title The role of copper in the pMMO of Methylococcus capsulatus bath: a structural vs. catalytic function.
Related PDB
Related UniProtKB
[10]
Resource
Comments
Medline ID
PubMed ID 9056845
Journal Biochem Soc Trans
Year 1997
Volume 25
Pages 65-9
Authors Fontecave M, Menage S, Duboc-Toia C, Vincent JM, Lambeaux C
Title Model complexes of di-iron sites in methane mono-oxygenase and ribonucleotide reductase: structure and reactivity.
Related PDB
Related UniProtKB
[11]
Resource
Comments
Medline ID
PubMed ID 9136884
Journal Biochemistry
Year 1997
Volume 36
Pages 5223-33
Authors Liu Y, Nesheim JC, Paulsen KE, Stankovich MT, Lipscomb JD
Title Roles of the methane monooxygenase reductase component in the regulation of catalysis.
Related PDB
Related UniProtKB
[12]
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Comments
Medline ID
PubMed ID 9054392
Journal J Biol Chem
Year 1997
Volume 272
Pages 7022-6
Authors Davydov A, Davydov R, Graslund A, Lipscomb JD, Andersson KK
Title Radiolytic reduction of methane monooxygenase dinuclear iron cluster at 77 K. EPR evidence for conformational change upon reduction or binding of component B to the diferric state.
Related PDB
Related UniProtKB
[13]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 9070438
Journal Protein Sci
Year 1997
Volume 6
Pages 556-68
Authors Elango N, Radhakrishnan R, Froland WA, Wallar BJ, Earhart CA, Lipscomb JD, Ohlendorf DH
Title Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b.
Related PDB 1mhy 1mhz
Related UniProtKB
[14]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
Medline ID 97469634
PubMed ID 9329079
Journal Proteins
Year 1997
Volume 29
Pages 141-52
Authors Rosenzweig AC, Brandstetter H, Whittington DA, Nordlund P, Lippard SJ, Frederick CA
Title Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions.
Related PDB 1mty
Related UniProtKB P22869
[15]
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Comments
Medline ID
PubMed ID 8999792
Journal Science
Year 1997
Volume 275
Pages 515-8
Authors Shu L, Nesheim JC, Kauffmann K, Munck E, Lipscomb JD, Que L Jr
Title An Fe2IVO2 diamond core structure for the key intermediate Q of methane monooxygenase.
Related PDB
Related UniProtKB
[16]
Resource
Comments
Medline ID
PubMed ID 10231531
Journal Biochemistry
Year 1999
Volume 38
Pages 5799-812
Authors Chang SL, Wallar BJ, Lipscomb JD, Mayo KH
Title Solution structure of component B from methane monooxygenase derived through heteronuclear NMR and molecular modeling.
Related PDB
Related UniProtKB
[17]
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Medline ID
PubMed ID 10346895
Journal Biochemistry
Year 1999
Volume 38
Pages 6752-60
Authors Gallagher SC, Callaghan AJ, Zhao J, Dalton H, Trewhella J
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Related UniProtKB
[18]
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Medline ID
PubMed ID 10504247
Journal Biochemistry
Year 1999
Volume 38
Pages 12768-85
Authors Gassner GT, Lippard SJ
Title Component interactions in the soluble methane monooxygenase system from Methylococcus capsulatus (Bath).
Related PDB
Related UniProtKB
[19]
Resource
Comments
Medline ID
PubMed ID 10194363
Journal Biochemistry
Year 1999
Volume 38
Pages 4423-32
Authors Lee SK, Lipscomb JD
Title Oxygen activation catalyzed by methane monooxygenase hydroxylase component: proton delivery during the O-O bond cleavage steps.
Related PDB
Related UniProtKB
[20]
Resource
Comments
Medline ID
PubMed ID 10381404
Journal Chem Biol
Year 1999
Volume 6
Pages 441-9
Authors Brandstetter H, Whittington DA, Lippard SJ, Frederick CA
Title Mutational and structural analyses of the regulatory protein B of soluble methane monooxygenase from Methylococcus capsulatus (Bath).
Related PDB
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID 10196150
Journal J Biol Chem
Year 1999
Volume 274
Pages 10771-6
Authors Valentine AM, LeTadic-Biadatti MH, Toy PH, Newcomb M, Lippard SJ
Title Oxidation of ultrafast radical clock substrate probes by the soluble methane monooxygenase from Methylococcus capsulatus (Bath).
Related PDB
Related UniProtKB
[22]
Resource
Comments
Medline ID
PubMed ID 10393915
Journal Proc Natl Acad Sci U S A
Year 1999
Volume 96
Pages 7877-82
Authors Walters KJ, Gassner GT, Lippard SJ, Wagner G
Title Structure of the soluble methane monooxygenase regulatory protein B.
Related PDB
Related UniProtKB
[23]
Resource
Comments
Medline ID
PubMed ID 11063587
Journal Biochemistry
Year 2000
Volume 39
Pages 13503-15
Authors Brazeau BJ, Lipscomb JD
Title Kinetics and activation thermodynamics of methane monooxygenase compound Q formation and reaction with substrates.
Related PDB
Related UniProtKB
[24]
Resource
Comments
Medline ID
PubMed ID 10742188
Journal Curr Opin Chem Biol
Year 2000
Volume 4
Pages 235-41
Authors Westerheide L, Pascaly M, Krebs B
Title Methane monooxygenase and its related biomimetic models.
Related PDB
Related UniProtKB
[25]
Resource
Comments
Medline ID
PubMed ID 10714702
Journal J Inorg Biochem
Year 2000
Volume 78
Pages 23-34
Authors Yoshizawa K
Title Two-step concerted mechanism for methane hydroxylation on the diiron active site of soluble methane monooxygenase.
Related PDB
Related UniProtKB
[26]
Resource
Comments
Medline ID
PubMed ID 11329291
Journal Biochemistry
Year 2001
Volume 40
Pages 2220-33
Authors Wallar BJ, Lipscomb JD
Title Methane monooxygenase component B mutants alter the kinetics of steps throughout the catalytic cycle.
Related PDB
Related UniProtKB
[27]
Resource
Comments
Medline ID
PubMed ID 11459514
Journal J Am Chem Soc
Year 2001
Volume 123
Pages 7194-5
Authors White MC, Doyle AG, Jacobsen EN
Title A synthetically useful, self-assembling MMO mimic system for catalytic alkene epoxidation with aqueous H2O2.
Related PDB
Related UniProtKB
[28]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS).
Medline ID 21350666
PubMed ID 11456616
Journal J Am Chem Soc
Year 2001
Volume 123
Pages 827-38
Authors Whittington DA, Lippard SJ
Title Crystal structures of the soluble methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath) demonstrating geometrical variability at the dinuclear iron active site.
Related PDB 1fyz 1fz0 1fz1 1fz2 1fz3 1fz4 1fz5
Related UniProtKB P22869
[29]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11456795
Journal J Am Chem Soc
Year 2001
Volume 123
Pages 1794-5
Authors Whittington DA, Sazinsky MH, Lippard SJ
Title X-ray crystal structure of alcohol products bound at the active site of soluble methane monooxygenase hydroxylase.
Related PDB 1fz7
Related UniProtKB
[30]
Resource
Comments
Medline ID
PubMed ID 11851404
Journal Biochemistry
Year 2002
Volume 41
Pages 2571-9
Authors Balendra S, Lesieur C, Smith TJ, Dalton H
Title Positively charged amino acids are essential for electron transfer and protein-protein interactions in the soluble methane monooxygenase complex from Methylococcus capsulatus (Bath).
Related PDB
Related UniProtKB
[31]
Resource
Comments
Medline ID
PubMed ID 11772001
Journal Biochemistry
Year 2002
Volume 41
Pages 42-51
Authors Muller J, Lugovskoy AA, Wagner G, Lippard SJ
Title NMR structure of the [2Fe-2S] ferredoxin domain from soluble methane monooxygenase reductase and interaction with its hydroxylase.
Related PDB
Related UniProtKB
[32]
Resource
Comments
Medline ID
PubMed ID 11952785
Journal Eur J Biochem
Year 2002
Volume 269
Pages 1835-43
Authors Callaghan AJ, Smith TJ, Slade SE, Dalton H
Title Residues near the N-terminus of protein B control autocatalytic proteolysis and the activity of soluble methane mono-oxygenase.
Related PDB
Related UniProtKB
[33]
Resource
Comments
Medline ID
PubMed ID 11849083
Journal Inorg Chem
Year 2002
Volume 41
Pages 827-37
Authors Lee D, Lippard SJ
Title Synthetic analogue of the [Fe(2)(mu-OH)(2)(mu-O(2)CR)](3+) core of soluble methane monooxygenase hydroxylase via synthesis and dioxygen reactivity of carboxylate-bridged diiron(II) complexes.
Related PDB
Related UniProtKB
[34]
Resource
Comments
Medline ID
PubMed ID 11942853
Journal J Am Chem Soc
Year 2002
Volume 124
Pages 4135-48
Authors Musaev DG, Basch H, Morokuma K
Title Theoretical study of the mechanism of alkane hydroxylation and ethylene epoxidation reactions catalyzed by diiron bis-oxo complexes. The effect of substrate molecules.
Related PDB
Related UniProtKB
[35]
Resource
Comments
Medline ID
PubMed ID 12059209
Journal J Am Chem Soc
Year 2002
Volume 124
Pages 6879-86
Authors Newcomb M, Shen R, Lu Y, Coon MJ, Hollenberg PF, Kopp DA, Lippard SJ
Title Evaluation of norcarane as a probe for radicals in cytochome p450- and soluble methane monooxygenase-catalyzed hydroxylation reactions.
Related PDB
Related UniProtKB
[36]
Resource
Comments
Medline ID
PubMed ID 11890772
Journal J Am Chem Soc
Year 2002
Volume 124
Pages 2416-7
Authors Tshuva EY, Lee D, Bu W, Lippard SJ
Title Catalytic oxidation by a carboxylate-bridged non-heme diiron complex.
Related PDB
Related UniProtKB
[37]
Resource
Comments
Medline ID
PubMed ID 11913390
Journal J Comput Chem
Year 2002
Volume 23
Pages 59-76
Authors Torrent M, Musaev DG, Basch H, Morokuma K
Title Computational studies of reaction mechanisms of methane monooxygenase and ribonucleotide reductase.
Related PDB
Related UniProtKB

Comments
This enzyme, methane monooxygenase (MMO; EC 1.14.13.25), is made up of three components, component A (MMO hydroxylase, MMOH), component B (MMOB: Swiss-prot, P27356), and component C (MMO reductase, MMOR: Swiss-prot, P22868, Q53563).
Whilst the component B (MMOB) is a regulatory unit of this enzyme by interacting with alpha chains of the component A, the component C (MMOR) transfers two electron from NADH to the component A, with FAD and [2Fe-2S] cluster.
This entry corresponds to the component A (MMOH). The component A (MMOH) consists of two alpha chains (Swiss-prot, P22869, P27353) with the binuclear iron center, two beta chains (Swiss-prot, P18798, P27354) and two gamma chains (Swiss-prot, P11987, P27355).
This enzyme catalyzes the following reactions:
(A) Oxygenation of methane (CH4) by O2, giving methanol (CH3OH) and water (H2O) at dinuclear iron site:
(B) Reduction of dinuclear iron site by NAD(P)H:

Created Updated
2004-07-29 2018-04-23