DB code: M00167

RLCP classification 1.13.30000.10 : Hydrolysis
CATH domain 3.30.300.50 : GMP Synthetase; Chain A, domain 3
3.30.300.50 : GMP Synthetase; Chain A, domain 3
2.40.10.10 : Thrombin, subunit H Catalytic domain
2.40.10.10 : Thrombin, subunit H Catalytic domain
E.C. 3.4.21.12
CSA 2lpr
M-CSA 2lpr
MACiE

CATH domain Related DB codes (homologues)
2.40.10.10 : Thrombin, subunit H M00139 D00214 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00197 D00211 D00212 D00216 M00212 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00317 M00348 M00349 T00074 T00410 T00411

Uniprot Enzyme Name
UniprotKB Protein name Synonyms MEROPS Pfam
P00778 Alpha-lytic protease
EC 3.4.21.12
Alpha-lytic endopeptidase
S01.268 (Serine)
PF02983 (Pro_Al_protease)
PF00089 (Trypsin)
[Graphical View]

KEGG enzyme name
alpha-lytic endopeptidase
myxobacter alpha-lytic proteinase
alpha-lytic proteinase
alpha-lytic protease
Mycobacterium sorangium alpha-lytic proteinase
Myxobacter 495 alpha-lytic proteinase
alpha-lytic proteinase
Myxobacter alpha-lytic proteinase
Mycobacterium sorangium alpha-lytic proteinase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P00778 PRLA_LYSEN Preferential cleavage: Ala-|-Xaa, Val-|-Xaa in bacterial cell walls, elastin and other proteins.

KEGG Pathways
Map code Pathways E.C.

Compound table
Substrates Products Intermediates
KEGG-id C00012 C02065 C00001 C00012 C00098 I00087 I00085 I00086
E.C.
Compound Peptide Protein alanine H2O Peptide Oligopeptide Peptidyl-tetrahedral intermediate Acyl-enzyme Tetrahedral intermediate
Type peptide/protein peptide/protein H2O peptide/protein amine group,carboxyl group,peptide/protein
ChEBI 15377
PubChem 22247451
962
2proA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2proB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2proC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3proC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3proD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
4proC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
4proD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2proA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2proB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2proC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3proC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3proD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
4proC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
4proD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1boqA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbbA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbcA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbdA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbeA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbfA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbhA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbiA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbjA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbkA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gblA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbmA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p01A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p02A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p03A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p04A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p05A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p06A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p09A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p10A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p11E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p12E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qq4A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qrwA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qrxA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1talA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2alpA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2ullA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3proA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3proB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
4proA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
4proB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
5lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
6lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
7lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
8lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
9lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1boqA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbbA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2A (chain P)
1gbcA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-BLE (chain P)
1gbdA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2F (chain P)
1gbeA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbfA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2A (chain P)
1gbhA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-BLE (chain P)
1gbiA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:ALA-ALA-PRO-B2F (chain P) Unbound
1gbjA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1gbkA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2A (chain P)
1gblA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-BLE (chain P)
1gbmA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2F (chain P)
1p01A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:BOC-ALA-PRO-B2V (chain P)
1p02A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2A (chain P)
1p03A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2V (chain P)
1p04A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2I (chain P)
1p05A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-BNO (chain P)
1p06A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:ALA-ALA-PRO-B2F (chain P) Unbound
1p09A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1p10A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2V (chain P)
1p11E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:BOC-ALA-ALA-PRO-PVA-LAC-ALA (chain P), BOC-ALA-ALA-PRO-PVA (chain I)
1p12E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:BOC-ALA-ALA-PRO-PVA-LAC-ALA (chain I) Unbound
1qq4A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qrwA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1qrxA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1talA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2alpA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2V (chain P)
2ullA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-BNO (chain P)
3proA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:2AB
3proB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:2AB
4proA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
4proB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound
5lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2A (chain P)
6lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-BNO (chain P)
7lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-BLE (chain P)
8lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-B2F (chain P)
9lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:ALA-ALA-PRO-BLE (chain P)

Reference for Active-site residues
resource references E.C.
Swiss-prot;P00778

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
2proA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2proB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2proC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3proC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3proD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
4proC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
4proD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2proA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2proB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2proC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3proC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3proD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
4proC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
4proD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1boqA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 36;ASP 63
1gbaA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gbbA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gbcA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gbdA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gbeA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gbfA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gbhA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gbiA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gbjA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gbkA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gblA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1gbmA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1p01A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1p02A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1p03A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1p04A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1p05A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1p06A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1p09A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1p10A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1p11E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1p12E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1qq4A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 36;ASP 63
1qrwA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 36;ASP 63
1qrxA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 36;ASP 63
1talA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
2alpA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
2lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
2ullA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
3lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
3proA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 36;ASP 63
3proB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 36;ASP 63
4proA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 36;ASP 63
4proB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 36;ASP 63
5lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
6lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
7lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
8lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
9lprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1boqA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 143 GLY 141;SER 143
1gbaA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A, G216A
1gbbA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A, G216A
1gbcA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A, G216A
1gbdA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A, G216A
1gbeA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A, G216L
1gbfA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A, G216L
1gbhA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A, G216L
1gbiA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A, G216L
1gbjA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A
1gbkA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A
1gblA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A
1gbmA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M190A
1p01A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1p02A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1p03A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1p04A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1p05A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1p06A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1p09A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M213A
1p10A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M213A
1p11E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1p12E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1qq4A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 143 GLY 141;SER 143 mutant R102H, G134S
1qrwA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 143 GLY 141;SER 143 mutant R102H, G134S
1qrxA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 143 GLY 141;SER 143
1talA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
2alpA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
2lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M192A
2ullA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
3lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M192A
3proA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 143 GLY 141;SER 143 mutant M158A
3proB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 143 GLY 141;SER 143 mutant M158A
4proA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 143 GLY 141;SER 143 mutant M158A
4proB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 143 GLY 141;SER 143 mutant M158A
5lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M213A
6lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M213A
7lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M213A
8lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195 mutant M213A
9lprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[1]
equation (1), equation (2), equation (3), equation (4), p.768-771
[4]
Fig.1, p.424-428
[9]
Fig.6, p.7613-7614
[10]
p.7695-7696
[37]
Fig.3, p.10374-10376

References
[1]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Medline ID
PubMed ID 117110
Journal J Mol Biol
Year 1979
Volume 131
Pages 743-75
Authors Brayer GD, Delbaere LT, James MN
Title Molecular structure of the alpha-lytic protease from Myxobacter 495 at 2.8 Angstroms resolution.
Related PDB
Related UniProtKB P00778
[2]
Resource
Comments
Medline ID
PubMed ID 6769571
Journal Can J Biochem
Year 1980
Volume 58
Pages 252-71.
Authors James MN
Title An X-ray crystallographic approach to enzyme structure and function.
Related PDB
Related UniProtKB
[3]
Resource
Comments
Medline ID
PubMed ID 7038675
Journal Proc Natl Acad Sci U S A
Year 1981
Volume 78
Pages 7323-6
Authors Bachovchin WW, Kaiser R, Richards JH, Roberts JD
Title Catalytic mechanism of serine proteases: reexamination of the pH dependence of the histidyl 1J13C2-H coupling constant in the catalytic triad of alpha-lytic protease.
Related PDB
Related UniProtKB
[4]
Resource
Comments
Medline ID
PubMed ID 7049067
Journal Annu Rev Biophys Bioeng
Year 1982
Volume 11
Pages 419-44
Authors Steitz TA, Shulman RG
Title Crystallographic and NMR studies of the serine proteases.
Related PDB
Related UniProtKB
[5]
Resource
Comments
Medline ID
PubMed ID 6802183
Journal Biochim Biophys Acta
Year 1982
Volume 702
Pages 105-11
Authors Recchia J, Matthews CR, Rhee MJ, Horrocks WD Jr
Title Interresidue distance measurements in proteins. Fluorescent energy transfer between tryptophans and a Ru(III)(NH3)5-histidine complex in alpha-lytic protease and lysozyme.
Related PDB
Related UniProtKB
[6]
Resource
Comments
Medline ID
PubMed ID 6395886
Journal Biochemistry
Year 1984
Volume 23
Pages 5933-7
Authors Huang TH, Bachovchin WW, Griffin RG, Dobson CM
Title High-resolution nitrogen-15 nuclear magnetic resonance studies of alpha-lytic protease in solid state. Direct comparison of enzyme structure in solution and in the solid state.
Related PDB
Related UniProtKB
[7]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
Medline ID
PubMed ID 3900416
Journal J Mol Biol
Year 1985
Volume 184
Pages 479-502
Authors Fujinaga M, Delbaere LT, Brayer GD, James MN
Title Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure.
Related PDB 2alp
Related UniProtKB P00778
[8]
Resource
Comments
Medline ID
PubMed ID 3934665
Journal Proc Natl Acad Sci U S A
Year 1985
Volume 82
Pages 7948-51
Authors Bachovchin WW
Title Confirmation of the assignment of the low-field proton resonance of serine proteases by using specifically nitrogen-15 labeled enzyme.
Related PDB
Related UniProtKB
[9]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 3122831
Journal Biochemistry
Year 1987
Volume 26
Pages 7609-14
Authors Bone R, Shenvi AB, Kettner CA, Agard DA
Title Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid.
Related PDB 1p01
Related UniProtKB
[10]
Resource
Comments
Medline ID
PubMed ID 3207700
Journal Biochemistry
Year 1988
Volume 27
Pages 7689-97
Authors Bachovchin WW, Wong WY, Farr-Jones S, Shenvi AB, Kettner CA
Title Nitrogen-15 NMR spectroscopy of the catalytic-triad histidine of a serine protease in peptide boronic acid inhibitor complexes.
Related PDB
Related UniProtKB
[11]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 2611204
Journal Biochemistry
Year 1989
Volume 28
Pages 7600-9
Authors Bone R, Frank D, Kettner CA, Agard DA
Title Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates.
Related PDB 1p02 1p03 1p04 1p05 1p06
Related UniProtKB
[12]
Resource
Comments
Medline ID
PubMed ID 2646278
Journal J Bacteriol
Year 1989
Volume 171
Pages 1320-5
Authors Silen JL, Frank D, Fujishige A, Bone R, Agard DA
Title Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity.
Related PDB
Related UniProtKB
[13]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 2716847
Journal Nature
Year 1989
Volume 339
Pages 191-5
Authors Bone R, Silen JL, Agard DA
Title Structural plasticity broadens the specificity of an engineered protease.
Related PDB 1p09 1p10
Related UniProtKB
[14]
Resource
Comments
Medline ID
PubMed ID 2223778
Journal Biochemistry
Year 1990
Volume 29
Pages 7468-74
Authors Brothers HM 2nd, Kostic NM
Title Catalytic activity of the serine proteases alpha-chymotrypsin and alpha-lytic protease tagged at the active site with a (terpyridine)platinum(II) chromophore.
Related PDB
Related UniProtKB
[15]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 1931963
Journal Biochemistry
Year 1991
Volume 30
Pages 10388-98
Authors Bone R, Fujishige A, Kettner CA, Agard DA
Title Structural basis for broad specificity in alpha-lytic protease mutants.
Related PDB 2lpr 3lpr 5lpr 6lpr 7lpr 8lpr 9lpr
Related UniProtKB
[16]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 1998685
Journal Biochemistry
Year 1991
Volume 30
Pages 2263-72
Authors Bone R, Sampson NS, Bartlett PA, Agard DA
Title Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters.
Related PDB 1p11 1p12
Related UniProtKB
[17]
Resource
Comments
Medline ID
PubMed ID 1856870
Journal J Mol Biol
Year 1991
Volume 220
Pages 495-506
Authors Wilson C, Mace JE, Agard DA
Title Computational method for the design of enzymes with altered substrate specificity.
Related PDB
Related UniProtKB
[18]
Resource
Comments
Medline ID
PubMed ID 1896427
Journal Proteins
Year 1991
Volume 10
Pages 140-8
Authors Caldwell JW, Agard DA, Kollman PA
Title Free energy calculations on binding and catalysis by alpha-lytic protease: the role of substrate size in the P1 pocket.
Related PDB
Related UniProtKB
[19]
Resource
Comments
Medline ID
PubMed ID 1445861
Journal Biochemistry
Year 1992
Volume 31
Pages 11216-23
Authors Epstein DM, Abeles RH
Title Role of serine 214 and tyrosine 171, components of the S2 subsite of alpha-lytic protease, in catalysis.
Related PDB
Related UniProtKB
[20]
Resource
Comments
Medline ID
PubMed ID 8251483
Journal Biochemistry
Year 1993
Volume 32
Pages 12651-5
Authors Tsilikounas E, Kettner CA, Bachovchin WW
Title 11B NMR spectroscopy of peptide boronic acid inhibitor complexes of alpha-lytic protease. Direct evidence for tetrahedral boron in both boron-histidine and boron-serine adduct complexes.
Related PDB
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID 8445659
Journal J Mol Biol
Year 1993
Volume 229
Pages 996-1006
Authors Wilson C, Gregoret LM, Agard DA
Title Modeling side-chain conformation for homologous proteins using an energy-based rotamer search.
Related PDB
Related UniProtKB
[22]
Resource
Comments
Medline ID
PubMed ID 7944385
Journal Arch Biochem Biophys
Year 1994
Volume 314
Pages 132-41
Authors Haggett KD, Graham LD, Milner SJ, Whittaker RG
Title Purification and characterization of S1 mutants of alpha-lytic protease having altered catalytic properties.
Related PDB
Related UniProtKB
[23]
Resource
Comments
Medline ID
PubMed ID 8155642
Journal Biochemistry
Year 1994
Volume 33
Pages 4251-7
Authors Schellenberger V, Turck CW, Rutter WJ
Title Role of the S' subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni.
Related PDB
Related UniProtKB
[24]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 7500345
Journal J Mol Biol
Year 1995
Volume 254
Pages 720-36
Authors Mace JE, Agard DA
Title Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity.
Related PDB 1gba 1gbb 1gbc 1gbd 1gbe 1gbf 1gbh 1gbi 1gbj 1gbk 1gbl 1gbm
Related UniProtKB
[25]
Resource
Comments
Medline ID
PubMed ID 7643381
Journal J Mol Biol
Year 1995
Volume 251
Pages 116-34
Authors Mace JE, Wilk BJ, Agard DA
Title Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity.
Related PDB
Related UniProtKB
[26]
Resource
Comments
Medline ID
PubMed ID 9092819
Journal Biochemistry
Year 1997
Volume 36
Pages 3894-902
Authors Sohl JL, Shiau AK, Rader SD, Wilk BJ, Agard DA
Title Inhibition of alpha-lytic protease by pro region C-terminal steric occlusion of the active site.
Related PDB
Related UniProtKB
[27]
Resource
Comments
Medline ID
PubMed ID 9335113
Journal J Biomol NMR
Year 1997
Volume 10
Pages 21-7
Authors Davis JH, Agard DA, Handel TM, Basus VJ
Title Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to alpha-lytic protease.
Related PDB
Related UniProtKB
[28]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 9232638
Journal Protein Sci
Year 1997
Volume 6
Pages 1375-86
Authors Rader SD, Agard DA
Title Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution.
Related PDB 1tal 2ull
Related UniProtKB
[29]
Resource
Comments
Medline ID
PubMed ID 9353195
Journal Science
Year 1997
Volume 278
Pages 1128-32
Authors Ash EL, Sudmeier JL, De Fabo EC, Bachovchin WW
Title A low-barrier hydrogen bond in the catalytic triad of serine proteases? Theory versus experiment.
Related PDB
Related UniProtKB
[30]
Resource
Comments
Medline ID
PubMed ID 9601029
Journal Biochemistry
Year 1998
Volume 37
Pages 7696-707
Authors Davis JH, Agard DA
Title Relationship between enzyme specificity and the backbone dynamics of free and inhibited alpha-lytic protease.
Related PDB
Related UniProtKB
[31]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
Medline ID
PubMed ID 9724517
Journal Biochemistry
Year 1998
Volume 37
Pages 12058-67
Authors Peters RJ, Shiau AK, Sohl JL, Anderson DE, Tang G, Silen JL, Agard DA
Title Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease.
Related PDB 1boq
Related UniProtKB P00778
[32]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
Medline ID
PubMed ID 9808037
Journal Nat Struct Biol
Year 1998
Volume 5
Pages 945-50
Authors Sauter NK, Mau T, Rader SD, Agard DA
Title Structure of alpha-lytic protease complexed with its pro region.
Related PDB 2pro 3pro 4pro
Related UniProtKB P00778
[33]
Resource
Comments
Medline ID
PubMed ID 9796818
Journal Nature
Year 1998
Volume 395
Pages 817-9
Authors Sohl JL, Jaswal SS, Agard DA
Title Unfolded conformations of alpha-lytic protease are more stable than its native state.
Related PDB
Related UniProtKB
[34]
Resource
Comments
Medline ID
PubMed ID 9931265
Journal J Mol Biol
Year 1999
Volume 286
Pages 267-78
Authors Miller DW, Agard DA
Title Enzyme specificity under dynamic control: a normal mode analysis of alpha-lytic protease.
Related PDB
Related UniProtKB
[35]
Resource
Comments
Medline ID
PubMed ID 10500115
Journal Proc Natl Acad Sci U S A
Year 1999
Volume 96
Pages 11008-14
Authors Cunningham EL, Jaswal SS, Sohl JL, Agard DA
Title Kinetic stability as a mechanism for protease longevity.
Related PDB
Related UniProtKB
[36]
Resource
Comments
Medline ID
PubMed ID 10802737
Journal Nat Struct Biol
Year 2000
Volume 7
Pages 394-7
Authors Derman AI, Agard DA
Title Two energetically disparate folding pathways of alpha-lytic protease share a single transition state.
Related PDB
Related UniProtKB
[37]
Resource
Comments
Medline ID
PubMed ID 10984533
Journal Proc Natl Acad Sci U S A
Year 2000
Volume 97
Pages 10371-6
Authors Ash EL, Sudmeier JL, Day RM, Vincent M, Torchilin EV, Haddad KC, Bradshaw EM, Sanford DG, Bachovchin WW
Title Unusual 1H NMR chemical shifts support (His) Cepsilon 1...O==C H-bond: proposal for reaction-driven ring flip mechanism in serine protease catalysis.
Related PDB
Related UniProtKB
[38]
Resource
Comments
Medline ID
PubMed ID 10944390
Journal Proteins
Year 2000
Volume 41
Pages 21-32
Authors Inuzuka Y, Lazaridis T
Title On the unfolding of alpha-lytic protease and the role of the pro region.
Related PDB
Related UniProtKB
[39]
Resource
Comments
Medline ID
PubMed ID 11420442
Journal Protein Sci
Year 2001
Volume 10
Pages 1403-14
Authors Ota N, Agard DA
Title Enzyme specificity under dynamic control II: Principal component analysis of alpha-lytic protease using global and local solvent boundary conditions.
Related PDB
Related UniProtKB
[40]
Resource
Comments
Medline ID
PubMed ID 12102628
Journal Biochemistry
Year 2002
Volume 41
Pages 8860-7
Authors Cunningham EL, Mau T, Truhlar SM, Agard DA
Title The pro region N-terminal domain provides specific interactions required for catalysis of alpha-lytic protease folding.
Related PDB
Related UniProtKB
[41]
Resource
Comments
Medline ID
PubMed ID 11814352
Journal Biochemistry
Year 2002
Volume 41
Pages 1587-90
Authors Ivanov D, Bachovchin WW, Redfield AG
Title Boron-11 pure quadrupole resonance investigation of peptide boronic acid inhibitors bound to alpha-lytic protease.
Related PDB
Related UniProtKB
[42]
Resource
Comments
Medline ID
PubMed ID 11797014
Journal Nature
Year 2002
Volume 415
Pages 343-6
Authors Jaswal SS, Sohl JL, Davis JH, Agard DA
Title Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability.
Related PDB
Related UniProtKB
[43]
Resource
Comments
Medline ID
PubMed ID 14609332
Journal Biochemistry
Year 2003
Volume 42
Pages 13212-9
Authors Cunningham EL, Agard DA
Title Interdependent folding of the N- and C-terminal domains defines the cooperative folding of alpha-lytic protease.
Related PDB
Related UniProtKB
[44]
Resource
Comments
Medline ID
PubMed ID 14504841
Journal Eur Biophys J
Year 2004
Volume 33
Pages 83-8
Authors Cabrita LD, Bottomley SP
Title How do proteins avoid becoming too stable? Biophysical studies into metastable proteins.
Related PDB
Related UniProtKB
[45]
Resource
Comments
Medline ID
PubMed ID 15111063
Journal J Mol Biol
Year 2004
Volume 338
Pages 999-1013
Authors Fuhrmann CN, Kelch BA, Ota N, Agard DA
Title The 0.83 A resolution crystal structure of alpha-lytic protease reveals the detailed structure of the active site and identifies a source of conformational strain.
Related PDB
Related UniProtKB
[46]
Resource
Comments
Medline ID
PubMed ID 14739318
Journal Protein Sci
Year 2004
Volume 13
Pages 325-31
Authors Cunningham EL, Agard DA
Title Disabling the folding catalyst is the last critical step in alpha-lytic protease folding.
Related PDB
Related UniProtKB

Comments
This enzyme belongs to the peptidase family-S1E.
According to the literature [4] & [37], this enzyme has got a catalytic triad, composed of Ser/His/Asp, with a similar catalytic mechanism to that of trypsin (D00197 in EzCatDB).

Created Updated
2004-11-18 2011-02-23