DB code: M00212

RLCP classification 1.13.30000.10 : Hydrolysis
CATH domain 2.10.25.10 : Laminin
2.10.25.10 : Laminin
2.40.10.10 : Thrombin, subunit H Catalytic domain
2.40.10.10 : Thrombin, subunit H Catalytic domain
E.C. 3.4.21.69
CSA
M-CSA
MACiE

CATH domain Related DB codes (homologues)
2.40.10.10 : Thrombin, subunit H M00139 D00214 M00167 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00197 D00211 D00212 D00216 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00317 M00348 M00349 T00074 T00410 T00411
2.10.25.10 : Laminin M00139 M00133 M00152 M00155 M00315 M00316

Uniprot Enzyme Name
UniprotKB Protein name Synonyms Contains RefSeq MEROPS Pfam
P04070 Vitamin K-dependent protein C
EC 3.4.21.69
Anticoagulant protein C
Autoprothrombin IIA
Blood coagulation factor XIV
Vitamin K-dependent protein C light chain
Vitamin K-dependent protein C heavy chain
Activation peptide
NP_000303.1 (Protein)
NM_000312.3 (DNA/RNA sequence)
S01.218 (Serine)
PF00594 (Gla)
PF00089 (Trypsin)
[Graphical View]

KEGG enzyme name
protein C (activated)
blood-coagulation factor XIVa
activated blood coagulation factor XIV
activated protein C
autoprothrombin II-A
protein Ca
APC
GSAPC

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P04070 PROC_HUMAN Degradation of blood coagulation factors Va and VIIIa. Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain, this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.

KEGG Pathways
Map code Pathways E.C.

Compound table
Substrates Products Intermediates
KEGG-id C03780 C04001 C00017 C00001 C00017 C00012 I00087 I00085 I00086
E.C.
Compound Blood coagulation Factor Va Blood coagulation Factor VIIIa Protein H2O Protein Peptide Peptidyl-tetrahedral intermediate Acyl-enzyme Tetrahedral intermediate
Type peptide/protein peptide/protein peptide/protein H2O peptide/protein peptide/protein
ChEBI 15377
PubChem 22247451
962
1autL01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1autL02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1autC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:DPN-PRO-MAI(chain P)
1autC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
Swiss-prot;P04070 & literature [29], [35]

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1autL01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1autL02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1autC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1autC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[29]

References
[1]
Resource
Comments
Medline ID
PubMed ID 3584108
Journal J Biol Chem
Year 1987
Volume 262
Pages 7105-8
Authors Hill KA, Castellino FJ
Title Topographical relationships between the monovalent and divalent cation binding sites of des-1-41-light chain bovine plasma protein C and des-1-41-light chain-activated bovine plasma protein C.
Related PDB
Related UniProtKB
[2]
Resource
Comments
Medline ID
PubMed ID 3584107
Journal J Biol Chem
Year 1987
Volume 262
Pages 7098-104
Authors Hill KA, Steiner SA, Castellino FJ
Title 205Tl+ as a spectroscopic probe of the monovalent cation binding sites of bovine plasma activated protein C and des-1-41-light-chain-activated protein C.
Related PDB
Related UniProtKB
[3]
Resource
Comments
Medline ID
PubMed ID 2839161
Journal Biochem J
Year 1988
Volume 251
Pages 229-36
Authors Hill KA, Steiner SA, Castellino FJ
Title Estimation of the distance between the divalent cation binding site of des-1-41-light chain-activated bovine plasma protein C and a nitroxide spin label attached to the active-site serine residue.
Related PDB
Related UniProtKB
[4]
Resource
Comments
Medline ID
PubMed ID 2538457
Journal J Biol Chem
Year 1989
Volume 264
Pages 4743-6
Authors Esmon CT
Title The roles of protein C and thrombomodulin in the regulation of blood coagulation.
Related PDB
Related UniProtKB
[5]
Resource
Comments
Medline ID
PubMed ID 1939075
Journal J Biol Chem
Year 1991
Volume 266
Pages 20139-45
Authors Fay PJ, Smudzin TM, Walker FJ
Title Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity.
Related PDB
Related UniProtKB
[6]
Resource
Comments
Medline ID
PubMed ID 1761551
Journal J Biol Chem
Year 1991
Volume 266
Pages 24514-9
Authors Mesters RM, Houghten RA, Griffin JH
Title Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity.
Related PDB
Related UniProtKB
[7]
Resource
Comments
Medline ID
PubMed ID 1657904
Journal J Biol Chem
Year 1991
Volume 266
Pages 19886-9
Authors Zushi M, Gomi K, Honda G, Kondo S, Yamamoto S, Hayashi T, Suzuki K
Title Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C.
Related PDB
Related UniProtKB
[8]
Resource
Comments
Medline ID
PubMed ID 1317308
Journal FASEB J
Year 1992
Volume 6
Pages 2561-7
Authors Walker FJ, Fay PJ
Title Regulation of blood coagulation by the protein C system.
Related PDB
Related UniProtKB
[9]
Resource
Comments
Medline ID
PubMed ID 1309772
Journal J Biol Chem
Year 1992
Volume 267
Pages 703-6
Authors Hogg PJ, Ohlin AK, Stenflo J
Title Identification of structural domains in protein C involved in its interaction with thrombin-thrombomodulin on the surface of endothelial cells.
Related PDB
Related UniProtKB
[10]
Resource
Comments
Medline ID
PubMed ID 1464619
Journal J Biol Chem
Year 1992
Volume 267
Pages 26078-84
Authors Zhang L, Castellino FJ
Title Influence of specific gamma-carboxyglutamic acid residues on the integrity of the calcium-dependent conformation of human protein C.
Related PDB
Related UniProtKB
[11]
Resource
Comments
Medline ID
PubMed ID 8216224
Journal Biochem J
Year 1993
Volume 295
Pages 239-45
Authors Hermans JM, Stone SR
Title Interaction of activated protein C with serpins.
Related PDB
Related UniProtKB
[12]
Resource
Comments
Medline ID
PubMed ID 8251484
Journal Biochemistry
Year 1993
Volume 32
Pages 12656-63
Authors Mesters RM, Heeb MJ, Griffin JH
Title A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va.
Related PDB
Related UniProtKB
[13]
Resource
Comments VARIANTS TRP-38; CYS-42; HIS-42; GLN-271 AND ASN-294.
Medline ID 93313192
PubMed ID 8324221
Journal Blood
Year 1993
Volume 82
Pages 159-68
Authors Gandrille S, Alhenc-Gelas M, Gaussem P, Aillaud MF, Dupuy E, Juhan-Vague I, Aiach M
Title Five novel mutations located in exons III and IX of the protein C gene in patients presenting with defective protein C anticoagulant activity.
Related PDB
Related UniProtKB P04070
[14]
Resource
Comments
Medline ID
PubMed ID 8130392
Journal Glycobiology
Year 1993
Volume 3
Pages 597-608
Authors Yan SB, Chao YB, van Halbeek H
Title Novel Asn-linked oligosaccharides terminating in GalNAc beta (1-->4)[Fuc alpha (1-->3)]GlcNAc beta (1-->.) are present in recombinant human protein C expressed in human kidney 293 cells.
Related PDB
Related UniProtKB
[15]
Resource
Comments NUCLEOTIDE SEQUENCE OF 43-64 FROM NUCLEIC ACID, AND VARIANT GLY-57 (YONAGO).
Medline ID 93237511
PubMed ID 8477066
Journal Int J Hematol
Year 1993
Volume 57
Pages 9-14
Authors Mimuro J, Muramatsu S, Kaneko M, Yoshitake S, Iijima K, Nakamura K, Sakata Y, Matsuda M
Title An abnormal protein C (protein C Yonago) with an amino acid substitution of Gly for Arg-15 caused by a single base mutation of C to G in codon 57 (CGG-->GGG). Deteriorated calcium-dependent conformation of the gamma-carboxyglutamic acid domain relevant to a thrombotic tendency.
Related PDB
Related UniProtKB P04070
[16]
Resource
Comments
Medline ID
PubMed ID 8104182
Journal J Biol Chem
Year 1993
Volume 268
Pages 19943-8
Authors Rezaie AR, Esmon CT
Title Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors.
Related PDB
Related UniProtKB
[17]
Resource
Comments
Medline ID
PubMed ID 8505327
Journal J Biol Chem
Year 1993
Volume 268
Pages 12040-5
Authors Zhang L, Castellino FJ
Title The contributions of individual gamma-carboxyglutamic acid residues in the calcium-dependent binding of recombinant human protein C to acidic phospholipid vesicles.
Related PDB
Related UniProtKB
[18]
Resource
Comments
Medline ID
PubMed ID 8401232
Journal Protein Sci
Year 1993
Volume 2
Pages 1482-9
Authors Mesters RM, Heeb MJ, Griffin JH
Title Interactions and inhibition of blood coagulation factor Va involving residues 311-325 of activated protein C.
Related PDB
Related UniProtKB
[19]
Resource
Comments REVIEW ON PROC VARIANTS.
Medline ID 93190290
PubMed ID 8446940
Journal Thromb Haemost
Year 1993
Volume 69
Pages 77-84
Authors Reitsma PH, Poort SR, Bernardi F, Gandrille S, Long GL, Sala N, Cooper DN
Title Protein C deficiency: a database of mutations. For the Protein C & S Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis.
Related PDB
Related UniProtKB P04070
[20]
Resource
Comments
Medline ID
PubMed ID 7980464
Journal Biochem J
Year 1994
Volume 303
Pages 929-33
Authors Grinnell BW, Gerlitz B, Berg DT
Title Identification of a region in protein C involved in thrombomodulin-stimulated activation by thrombin: potential repulsion at anion-binding site I in thrombin.
Related PDB
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID 8043441
Journal Br J Haematol
Year 1994
Volume 86
Pages 590-600
Authors Murakawa M, Okamura T, Kamura T, Kuroiwa M, Harada M, Niho Y
Title A comparative study of partial primary structures of the catalytic region of mammalian protein C.
Related PDB
Related UniProtKB
[22]
Resource
Comments
Medline ID
PubMed ID 7989361
Journal J Biol Chem
Year 1994
Volume 269
Pages 31869-80
Authors Kalafatis M, Rand MD, Mann KG
Title The mechanism of inactivation of human factor V and human factor Va by activated protein C.
Related PDB
Related UniProtKB
[23]
Resource
Comments
Medline ID
PubMed ID 7906267
Journal J Biol Chem
Year 1994
Volume 269
Pages 3151-4
Authors Rezaie AR, Mather T, Sussman F, Esmon CT
Title Mutation of Glu-80-->Lys results in a protein C mutant that no longer requires Ca2+ for rapid activation by the thrombin-thrombomodulin complex.
Related PDB
Related UniProtKB
[24]
Resource
Comments
Medline ID
PubMed ID 8106403
Journal J Biol Chem
Year 1994
Volume 269
Pages 3590-5
Authors Zhang L, Castellino FJ
Title The binding energy of human coagulation protein C to acidic phospholipid vesicles contains a major contribution from leucine 5 in the gamma-carboxyglutamic acid domain.
Related PDB
Related UniProtKB
[25]
Resource
Comments Model
Medline ID 94272342
PubMed ID 8003977
Journal Protein Sci
Year 1994
Volume 3
Pages 588-99
Authors Fisher CL, Greengard JS, Griffin JH
Title Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen.
Related PDB 2pct
Related UniProtKB
[26]
Resource
Comments
Medline ID
PubMed ID 7548032
Journal Biochemistry
Year 1995
Volume 34
Pages 12775-81
Authors Persson E, Ezban M, Shymko RM
Title Kinetics of the interaction between the human factor VIIIa subunits: effects of pH, ionic strength, Ca2+ concentration, heparin, and activated protein C-catalyzed proteolysis.
Related PDB
Related UniProtKB
[27]
Resource
Comments
Medline ID
PubMed ID 7547963
Journal Biochemistry
Year 1995
Volume 34
Pages 12221-6
Authors Rezaie AR, Esmon CT
Title Tryptophans 231 and 234 in protein C report the Ca(2+)-dependent conformational change required for activation by the thrombin-thrombomodulin complex.
Related PDB
Related UniProtKB
[28]
Resource
Comments
Medline ID
PubMed ID 7673148
Journal J Biol Chem
Year 1995
Volume 270
Pages 21158-66
Authors Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, Schwarz HP, Rosing J
Title Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.
Related PDB
Related UniProtKB
[29]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 84-461.
Medline ID 97157472
PubMed ID 9003757
Journal EMBO J
Year 1996
Volume 15
Pages 6822-31
Authors Mather T, Oganessyan V, Hof P, Huber R, Foundling S, Esmon C, Bode W
Title The 2.8 A crystal structure of Gla-domainless activated protein C.
Related PDB 1aut
Related UniProtKB P04070
[30]
Resource
Comments
Medline ID
PubMed ID 8902996
Journal Thromb Haemost
Year 1996
Volume 76
Pages 556-60
Authors De Cristofaro R
Title Effect of thrombomodulin on the molecular recognition and early catalytic events in thrombin-protein C interaction.
Related PDB
Related UniProtKB
[31]
Resource
Comments
Medline ID
PubMed ID 8713779
Journal Thromb Haemost
Year 1996
Volume 75
Pages 49-55
Authors Mori T, Takeya H, Nishioka J, Gabazza EC, Suzuki K
Title beta 2-Glycoprotein I modulates the anticoagulant activity of activated protein C on the phospholipid surface.
Related PDB
Related UniProtKB
[32]
Resource
Comments
Medline ID
PubMed ID 8815576
Journal Thromb Haemost
Year 1996
Volume 75
Pages 275-82
Authors Nishioka J, Ido M, Hayashi T, Suzuki K
Title The Gla26 residue of protein C is required for the binding of protein C to thrombomodulin and endothelial cell protein C receptor, but not to protein S and factor Va.
Related PDB
Related UniProtKB
[33]
Resource
Comments
Medline ID
PubMed ID 9334197
Journal J Biol Chem
Year 1997
Volume 272
Pages 26279-84
Authors Regan LM, Mollica JS, Rezaie AR, Esmon CT
Title The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C.
Related PDB
Related UniProtKB
[34]
Resource
Comments
Medline ID
PubMed ID 9300501
Journal Protein Sci
Year 1997
Volume 6
Pages 2016-27
Authors Egan JO, Kalafatis M, Mann KG
Title The effect of Arg306-->Ala and Arg506-->Gln substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S.
Related PDB
Related UniProtKB
[35]
Resource
Comments
Medline ID
PubMed ID 9198204
Journal Thromb Haemost
Year 1997
Volume 78
Pages 501-11
Authors Bode W, Brandstetter H, Mather T, Stubbs MT
Title Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C.
Related PDB
Related UniProtKB
[36]
Resource
Comments
Medline ID
PubMed ID 9988741
Journal J Biol Chem
Year 1999
Volume 274
Pages 4970-6
Authors He X, Rezaie AR
Title Identification and characterization of the sodium-binding site of activated protein C.
Related PDB
Related UniProtKB
[37]
Resource
Comments
Medline ID
PubMed ID 10096438
Journal Life Sci
Year 1999
Volume 64
Pages 879-85
Authors Martinez-Cruz R, Cordoba F, Mireles-Lopez JC, Zenteno E, Perez-Ortega E, Martinez M, Perez-Campos E
Title Effects of concanavalin A on protein-C activity.
Related PDB
Related UniProtKB
[38]
Resource
Comments
Medline ID
PubMed ID 10223294
Journal Proteins
Year 1999
Volume 35
Pages 218-34
Authors Knobe KE, Berntsdotter A, Shen L, Morser J, Dahlback B, Villoutreix BO
Title Probing the activation of protein C by the thrombin-thrombomodulin complex using structural analysis, site-directed mutagenesis, and computer modeling.
Related PDB
Related UniProtKB
[39]
Resource
Comments
Medline ID
PubMed ID 10456457
Journal Thromb Haemost
Year 1999
Volume 82
Pages 72-9
Authors Shen L, Villoutreix BO, Dahlback B
Title Involvement of Lys 62(217) and Lys 63(218) of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor.
Related PDB
Related UniProtKB
[40]
Resource
Comments
Medline ID
PubMed ID 10715104
Journal Biochemistry
Year 2000
Volume 39
Pages 2853-60
Authors Shen L, Dahlback B, Villoutreix BO
Title Tracking structural features leading to resistance of activated protein C to alpha 1-antitrypsin.
Related PDB
Related UniProtKB
[41]
Resource
Comments
Medline ID
PubMed ID 11106601
Journal Biophys J
Year 2000
Volume 79
Pages 2925-43
Authors Perera L, Foley C, Darden TA, Stafford D, Mather T, Esmon CT, Pedersen LG
Title Modeling zymogen protein C.
Related PDB
Related UniProtKB
[42]
Resource
Comments
Medline ID
PubMed ID 10688829
Journal Blood
Year 2000
Volume 95
Pages 1714-20
Authors O'Brien LM, Mastri M, Fay PJ
Title Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor Xase.
Related PDB
Related UniProtKB
[43]
Resource
Comments
Medline ID
PubMed ID 11380450
Journal Br J Haematol
Year 2001
Volume 113
Pages 642-8
Authors Lind B, Koefoed P, Thorsen S
Title Symptomatic type 1 protein C deficiency caused by a de novo Ser270Leu mutation in the catalytic domain.
Related PDB
Related UniProtKB
[44]
Resource
Comments
Medline ID
PubMed ID 11309403
Journal J Biol Chem
Year 2001
Volume 276
Pages 23105-8
Authors Friedrich U, Nicolaes GA, Villoutreix BO, Dahlback B
Title Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va.
Related PDB
Related UniProtKB
[45]
Resource
Comments
Medline ID
PubMed ID 11814362
Journal Biochemistry
Year 2002
Volume 41
Pages 1672-80
Authors Silveira JR, Kalafatis M, Tracy PB
Title Carbohydrate moieties on the procofactor factor V, but not the derived cofactor factor Va, regulate its inactivation by activated protein C.
Related PDB
Related UniProtKB
[46]
Resource
Comments
Medline ID
PubMed ID 11994010
Journal Biochemistry
Year 2002
Volume 41
Pages 6149-57
Authors Yang L, Manithody C, Rezaie AR
Title Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C.
Related PDB
Related UniProtKB
[47]
Resource
Comments
Medline ID
PubMed ID 12034704
Journal J Biol Chem
Year 2002
Volume 277
Pages 24851-4
Authors Oganesyan V, Oganesyan N, Terzyan S, Qu D, Dauter Z, Esmon NL, Esmon CT
Title The crystal structure of the endothelial protein C receptor and a bound phospholipid.
Related PDB
Related UniProtKB
[48]
Resource
Comments
Medline ID
PubMed ID 12029084
Journal J Biol Chem
Year 2002
Volume 277
Pages 28987-95
Authors Schmidt AE, Padmanabhan K, Underwood MC, Bode W, Mather T, Bajaj SP
Title Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops.
Related PDB
Related UniProtKB
[49]
Resource
Comments
Medline ID
PubMed ID 12595311
Journal Blood
Year 2003
Volume 101
Pages 4802-7
Authors Manithody C, Fay PJ, Rezaie AR
Title Exosite-dependent regulation of factor VIIIa by activated protein C.
Related PDB
Related UniProtKB
[50]
Resource
Comments
Medline ID
PubMed ID 12393635
Journal Blood
Year 2003
Volume 101
Pages 20-30
Authors Mann KG, Kalafatis M
Title Factor V: a combination of Dr Jekyll and Mr Hyde.
Related PDB
Related UniProtKB
[51]
Resource
Comments
Medline ID
PubMed ID 12446455
Journal Blood
Year 2003
Volume 101
Pages 2277-84
Authors Sun YH, Shen L, Dahlback B
Title Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding.
Related PDB
Related UniProtKB
[52]
Resource
Comments
Medline ID
PubMed ID 12970121
Journal Chest
Year 2003
Volume 124
Pages 26S-32S
Authors Esmon CT
Title The protein C pathway.
Related PDB
Related UniProtKB
[53]
Resource
Comments
Medline ID
PubMed ID 12554095
Journal Trends Cardiovasc Med
Year 2003
Volume 13
Pages 8-15
Authors Rezaie AR
Title Exosite-dependent regulation of the protein C anticoagulant pathway.
Related PDB
Related UniProtKB
[54]
Resource
Comments
Medline ID
PubMed ID 15337738
Journal J Biol Chem
Year 2004
Volume 279
Pages 47528-35
Authors Sun YH, Tran S, Norstrom EA, Dahlback B
Title Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C.
Related PDB
Related UniProtKB
[55]
Resource
Comments
Medline ID
PubMed ID 14660667
Journal J Biol Chem
Year 2004
Volume 279
Pages 6567-75
Authors van der Neut Kolfschoten M, Dirven RJ, Vos HL, Tans G, Rosing J, Bertina RM
Title Factor Va is inactivated by activated protein C in the absence of cleavage sites at Arg-306, Arg-506, and Arg-679.
Related PDB
Related UniProtKB
[56]
Resource
Comments
Medline ID
PubMed ID 15254039
Journal J Biol Chem
Year 2004
Volume 279
Pages 38519-24
Authors Yang L, Prasad S, Di Cera E, Rezaie AR
Title The conformation of the activation peptide of protein C is influenced by Ca2+ and Na+ binding.
Related PDB
Related UniProtKB
[57]
Resource
Comments
Medline ID
PubMed ID 15943976
Journal FEBS Lett
Year 2005
Volume 579
Pages 3310-6
Authors Dahlback B, Villoutreix BO
Title The anticoagulant protein C pathway.
Related PDB
Related UniProtKB
[58]
Resource
Comments
Medline ID
PubMed ID 16113785
Journal Thromb Haemost
Year 2005
Volume 94
Pages 60-8
Authors Yang L, Manithody C, Rezaie AR
Title The functional significance of the autolysis loop in protein C and activated protein C.
Related PDB
Related UniProtKB
[59]
Resource
Comments
Medline ID
PubMed ID 16418283
Journal Proc Natl Acad Sci U S A
Year 2006
Volume 103
Pages 879-84
Authors Yang L, Manithody C, Rezaie AR
Title Activation of protein C by the thrombin-thrombomodulin complex: Cooperative roles of Arg-35 of thrombin and Arg-67 of protein C.
Related PDB
Related UniProtKB

Comments
This enzyme belongs to the peptidase family-S1.
This enzyme is composed of a light chain and a heavy chain, which a single polypeptide is cleaved into. The light chain is composed of two EGF-like domains, whereas the heavy chain has the same catalytic domain as that of trypsin (D00197 in EzCatDB).

Created Updated
2004-08-24 2011-02-21