DB code: M00317

RLCP classification 1.13.30000.10 : Hydrolysis
CATH domain 3.40.50.410 : Rossmann fold
2.40.10.10 : Thrombin, subunit H Catalytic domain
2.40.10.10 : Thrombin, subunit H Catalytic domain
2.-.-.- :
2.60.40.690 : Immunoglobulin-like
2.60.120.290 : Jelly Rolls
1.50.10.20 : Glycosyltransferase
2.60.40.690 : Immunoglobulin-like
2.40.50.120 : OB fold (Dihydrolipoamide Acetyltransferase, E2P)
E.C. 3.4.21.47
CSA
M-CSA
MACiE

CATH domain Related DB codes (homologues)
2.40.10.10 : Thrombin, subunit H M00139 D00214 M00167 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00197 D00211 D00212 D00216 M00212 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00348 M00349 T00074 T00410 T00411
2.60.120.290 : Jelly Rolls M00139 M00227 M00315 M00316 M00348

Uniprot Enzyme Name
UniprotKB Protein name Synonyms Contains RefSeq MEROPS Pfam
P00751 Complement factor B
EC 3.4.21.47
C3/C5 convertase
Glycine-rich beta glycoprotein
GBG
PBF2
Properdin factor B
Complement factor B Ba fragment
Complement factor B Bb fragment
NP_001701.2 (Protein)
NM_001710.5 (DNA/RNA sequence)
S01.196 (Serine)
PF00084 (Sushi)
PF00089 (Trypsin)
PF00092 (VWA)
[Graphical View]
P01024 Complement C3
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
Complement C3 beta chain
Complement C3 alpha chain
C3a anaphylatoxin
Acylation stimulating protein
(ASP)
C3adesArg
Complement C3b alpha'' chain
Complement C3c alpha'' chain fragment 1
Complement C3dg fragment
Complement C3g fragment
Complement C3d fragment
Complement C3f fragment
Complement C3c alpha'' chain fragment 2
NP_000055.2 (Protein)
NM_000064.2 (DNA/RNA sequence)
I39.950 ()
PF00207 (A2M)
PF07678 (A2M_comp)
PF01835 (A2M_N)
PF07703 (A2M_N_2)
PF07677 (A2M_recep)
PF01821 (ANATO)
PF01759 (NTR)
PF10569 (Thiol-ester_cl)
[Graphical View]
Q91132 Cobra venom factor
CVF
CVFk
Complement C3 homolog
Cobra venom factor alpha chain
Cobra venom factor gamma chain
Cobra venom factor beta chain
I39.950 ()
PF00207 (A2M)
PF07678 (A2M_comp)
PF01835 (A2M_N)
PF07703 (A2M_N_2)
PF07677 (A2M_recep)
PF01821 (ANATO)
PF01759 (NTR)
PF10569 (Thiol-ester_cl)
[Graphical View]

KEGG enzyme name
Alternative-complement-pathway C3/C5 convertase
Complement component C3/C5 convertase (alternative)
Proenzyme factor B
Properdin factor B
C3 proactivator
Glycine-rich beta-glycoprotein
Heat-labile factor
C3 convertase
C3b,Bb,CVF,Bb,C5 convertase
(C3b)n,Bb
Complement C 3(C 5) convertase (amplification)
Alternative complement pathway C3(C5) convertase
C5 convertase
CVF,Bb
(CVF)-dependent glycine-rich-beta-glucoprotein
Cobra venom factor-dependent C3 convertase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P00751 CFAB_HUMAN Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b. Monomer. Secreted.
P01024 CO3_HUMAN C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with CR2 and VSIG4. Secreted.
Q91132 CO3_NAJKA Heterotrimer of alpha, beta and gamma chains. disulfide-linked. Secreted.

KEGG Pathways
Map code Pathways E.C.

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00305 L00091 L00092 C00001 L00093 L00079 L00094 L00095 I00087 I00085 I00086
E.C.
Compound Magnesium Complement C3 alpha chain Complement C5 alpha chain H2O Complement component C3a Complement component C3b Complement component C5a Complement component C5b Peptidyl-tetrahedral intermediate Acyl-enzyme tetrahedral intermediate
Type divalent metal (Ca2+, Mg2+) peptide/protein peptide/protein H2O peptide/protein peptide/protein peptide/protein peptide/protein
ChEBI 18420
15377
PubChem 888
962
22247451
1q0pA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1rrkA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_CO Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1rs0A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1rtkA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2ok5A04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winI01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winJ01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winK01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winL01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbF04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbH04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjI04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NI Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjJ04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NI Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjK04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NI Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjL04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_NI Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hrzD04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0D04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0I04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1rrkA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1rs0A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1rtkA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1dleA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1dleB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2ok5A05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winI02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winJ02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winK02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winL02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbF05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbH05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjI05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjJ05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjK05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjL05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hrzD05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0D05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0I05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1rrkA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1rs0A03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Transition-state-analogue:DFP Unbound Unbound
1rtkA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:GBS Unbound
1dleA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
1dleB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2ok5A06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winI03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winJ03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winK03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winL03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbF06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbH06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjI06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjJ06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjK06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjL06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hrzD06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0D06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0I06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hrzB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0G01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hrzB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0G02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hrzC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0C01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0H01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winD04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winF04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winH04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbD04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjD04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjF04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjH04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winB05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winD05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winF05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winH05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbB05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbD05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjB05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjD05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjF05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjH05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hrzC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0C02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0H02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winB06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winD06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winF06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2winH06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbB06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwbD06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjB06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjD06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjF06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
2xwjH06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hrzC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0C03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound
3hs0H03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
Literature [8] & Swiss-prot;P00751

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1q0pA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
1rrkA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
1rs0A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
1rtkA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2ok5A04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2winI01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2winJ01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2winK01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2winL01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2xwbF04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2xwbH04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2xwjI04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2xwjJ04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2xwjK04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
2xwjL04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
3hrzD04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
3hs0D04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
3hs0I04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 253;SER 255;THR 328(Magnesium binding)
1rrkA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
1rs0A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
1rtkA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
1dleA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
1dleB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 57;ASP 102
2ok5A05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
2winI02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
2winJ02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
2winK02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
2winL02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
2xwbF05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
2xwbH05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
2xwjI05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
2xwjJ05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
2xwjK05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
2xwjL05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
3hrzD05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
3hs0D05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
3hs0I05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 501;ASP 551
1rrkA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
1rs0A03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
1rtkA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
1dleA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
1dleB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 195 GLY 193;SER 195
2ok5A06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2winI03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2winJ03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2winK03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2winL03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2xwbF06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2xwbH06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2xwjI06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2xwjJ06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2xwjK06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2xwjL06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
3hrzD06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
3hs0D06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
3hs0I06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 674 GLY 672;SER 674
2winB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwbB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwbD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hrzB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hs0B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hs0G01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwbB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwbD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hrzB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hs0B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hs0G02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwbB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwbD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hrzC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hs0C01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hs0H01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winD04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winF04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winH04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwbB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwbD04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjB04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjD04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjF04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjH04 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winB05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winD05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winF05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winH05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwbB05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwbD05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjB05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjD05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjF05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2xwjH05 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hrzC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hs0C02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hs0H02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2winB06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASN 1641(Magnesium binding)
2winD06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASN 1641(Magnesium binding)
2winF06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASN 1641(Magnesium binding)
2winH06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASN 1641(Magnesium binding)
2xwbB06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASN 1641(Magnesium binding)
2xwbD06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASN 1641(Magnesium binding)
2xwjB06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASN 1641(Magnesium binding)
2xwjD06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASN 1641(Magnesium binding)
2xwjF06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASN 1641(Magnesium binding)
2xwjH06 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASN 1641(Magnesium binding)
3hrzC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 1620(Magnesium binding)
3hs0C03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
3hs0H03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[16]
Figure 5
[17]
Figure 1
[20]
Figure 1
[21]
Figure 3
[22]
Figure 6

References
[1]
Resource
Comments
Medline ID
PubMed ID 6559201
Journal J Immunol
Year 1984
Volume 132
Pages 1430-4
Authors Fishelson Z, Pangburn MK, Muller-Eberhard HJ
Title Characterization of the initial C3 convertase of the alternative pathway of human complement.
Related PDB
Related UniProtKB
[2]
Resource
Comments
Medline ID
PubMed ID 3638964
Journal Biochem J
Year 1986
Volume 235
Pages 723-30
Authors Pangburn MK, Muller-Eberhard HJ
Title The C3 convertase of the alternative pathway of human complement. Enzymic properties of the bimolecular proteinase.
Related PDB
Related UniProtKB
[3]
Resource
Comments
Medline ID
PubMed ID 3643213
Journal J Biol Chem
Year 1987
Volume 262
Pages 1519-25
Authors Pryzdial EL, Isenman DE
Title Alternative complement pathway activation fragment Ba binds to C3b. Evidence that formation of the factor B-C3b complex involves two discrete points of contact.
Related PDB
Related UniProtKB
[4]
Resource
Comments
Medline ID
PubMed ID 2433342
Journal J Immunol
Year 1987
Volume 138
Pages 1143-9
Authors Ueda A, Kearney JF, Roux KH, Volanakis JE
Title Probing functional sites on complement protein B with monoclonal antibodies. Evidence for C3b-binding sites on Ba.
Related PDB
Related UniProtKB
[5]
Resource
Comments
Medline ID
PubMed ID 3183384
Journal J Immunol
Year 1988
Volume 141
Pages 3895-901
Authors Kinoshita T, Takata Y, Kozono H, Takeda J, Hong KS, Inoue K
Title C5 convertase of the alternative complement pathway: covalent linkage between two C3b molecules within the trimolecular complex enzyme.
Related PDB
Related UniProtKB
[6]
Resource
Comments
Medline ID
PubMed ID 7649982
Journal J Biol Chem
Year 1995
Volume 270
Pages 19716-22
Authors Hourcade DE, Wagner LM, Oglesby TJ
Title Analysis of the short consensus repeats of human complement factor B by site-directed mutagenesis.
Related PDB
Related UniProtKB
[7]
Resource
Comments
Medline ID
PubMed ID 9642242
Journal J Biol Chem
Year 1998
Volume 273
Pages 16828-35
Authors Rawal N, Pangburn MK
Title C5 convertase of the alternative pathway of complement. Kinetic analysis of the free and surface-bound forms of the enzyme.
Related PDB
Related UniProtKB
[8]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 467-764.
Medline ID
PubMed ID 10637221
Journal EMBO J
Year 2000
Volume 19
Pages 164-73
Authors Jing H, Xu Y, Carson M, Moore D, Macon KJ, Volanakis JE, Narayana SV
Title New structural motifs on the chymotrypsin fold and their potential roles in complement factor B.
Related PDB 1dle
Related UniProtKB P00751
[9]
Resource
Comments
Medline ID
PubMed ID 10617628
Journal J Biol Chem
Year 2000
Volume 275
Pages 378-85
Authors Xu Y, Circolo A, Jing H, Wang Y, Narayana SV, Volanakis JE
Title Mutational analysis of the primary substrate specificity pocket of complement factor B. Asp(226) is a major structural determinant for p(1)-Arg binding.
Related PDB
Related UniProtKB
[10]
Resource
Comments
Medline ID
PubMed ID 10640753
Journal J Immunol
Year 2000
Volume 164
Pages 1379-85
Authors Rawal N, Pangburn MK
Title Functional role of the noncatalytic subunit of complement C5 convertase.
Related PDB
Related UniProtKB
[11]
Resource
Comments
Medline ID
PubMed ID 10966820
Journal J Mol Biol
Year 2000
Volume 301
Pages 1267-85
Authors Hinshelwood J, Perkins SJ
Title Conformational changes during the assembly of factor B from its domains by (1)H NMR spectroscopy and molecular modelling: their relevance to the regulation of factor B activity.
Related PDB
Related UniProtKB
[12]
Resource
Comments
Medline ID
PubMed ID 11414354
Journal Immunol Rev
Year 2001
Volume 180
Pages 123-35
Authors Xu Y, Narayana SV, Volanakis JE
Title Structural biology of the alternative pathway convertase.
Related PDB
Related UniProtKB
[13]
Resource
Comments
Medline ID
PubMed ID 11367526
Journal Int Immunopharmacol
Year 2001
Volume 1
Pages 415-22
Authors Rawal N, Pangburn MK
Title Structure/function of C5 convertases of complement.
Related PDB
Related UniProtKB
[14]
Resource
Comments
Medline ID
PubMed ID 11160326
Journal J Immunol
Year 2001
Volume 166
Pages 2635-42
Authors Rawal N, Pangburn M
Title Formation of high-affinity C5 convertases of the alternative pathway of complement.
Related PDB
Related UniProtKB
[15]
Resource
Comments
Medline ID
PubMed ID 12440962
Journal Biochem Soc Trans
Year 2002
Volume 30
Pages 1006-10
Authors Pangburn MK, Rawal N
Title Structure and function of complement C5 convertase enzymes.
Related PDB
Related UniProtKB
[16]
Resource
Comments
Medline ID
PubMed ID 12475199
Journal Chem Rev
Year 2002
Volume 102
Pages 4501-24
Authors Hedstrom L
Title Serine protease mechanism and specificity.
Related PDB
Related UniProtKB
[17]
Resource
Comments
Medline ID
PubMed ID 15068800
Journal Mol Cell
Year 2004
Volume 14
Pages 17-28
Authors Ponnuraj K, Xu Y, Macon K, Moore D, Volanakis JE, Narayana SV
Title Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.
Related PDB 1rrk 1rs0 1rtk
Related UniProtKB P00751
[18]
Resource
Comments
Medline ID
PubMed ID 15016353
Journal Structure
Year 2004
Volume 12
Pages 371-8
Authors Bhattacharya AA, Lupher ML Jr, Staunton DE, Liddington RC
Title Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation.
Related PDB 1q0p
Related UniProtKB P00751
[19]
Resource
Comments
Medline ID
PubMed ID 16301317
Journal J Biol Chem
Year 2006
Volume 281
Pages 2128-32
Authors Hourcade DE
Title The role of properdin in the assembly of the alternative pathway C3 convertases of complement.
Related PDB
Related UniProtKB
[20]
Resource
Comments
Medline ID
PubMed ID 17310251
Journal Nat Struct Mol Biol
Year 2007
Volume 14
Pages 224-8
Authors Milder FJ, Gomes L, Schouten A, Janssen BJ, Huizinga EG, Romijn RA, Hemrika W, Roos A, Daha MR, Gros P
Title Factor B structure provides insights into activation of the central protease of the complement system.
Related PDB 2ok5
Related UniProtKB P00751
[21]
Resource
Comments
Medline ID
PubMed ID 18064050
Journal Nat Rev Immunol
Year 2008
Volume 8
Pages 48-58
Authors Gros P, Milder FJ, Janssen BJ
Title Complement driven by conformational changes.
Related PDB
Related UniProtKB
[22]
Resource
Comments
Medline ID
PubMed ID 19574954
Journal EMBO J
Year 2009
Volume 28
Pages 2469-78
Authors Janssen BJ, Gomes L, Koning RI, Svergun DI, Koster AJ, Fritzinger DC, Vogel CW, Gros P
Title Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex.
Related PDB 3hrz 3hs0
Related UniProtKB P00751 Q91132
[23]
Resource
Comments
Medline ID
PubMed ID 19890040
Journal J Immunol
Year 2009
Volume 183
Pages 7347-51
Authors Torreira E, Tortajada A, Montes T, Rodriguez de Cordoba S, Llorca O
Title Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase.
Related PDB
Related UniProtKB
[24]
Resource
Comments
Medline ID
PubMed ID 19503103
Journal Nat Immunol
Year 2009
Volume 10
Pages 721-7
Authors Rooijakkers SH, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJ, van Strijp JA, Gros P
Title Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
Related PDB 2win
Related UniProtKB P00751 P01024
[25]
Resource
Comments
Medline ID
PubMed ID 19136636
Journal Proc Natl Acad Sci U S A
Year 2009
Volume 106
Pages 882-7
Authors Torreira E, Tortajada A, Montes T, Rodriguez de Cordoba S, Llorca O
Title 3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase.
Related PDB
Related UniProtKB
[26]
Resource
Comments
Medline ID
PubMed ID 21205667
Journal Science
Year 2010
Volume 330
Pages 1816-20
Authors Forneris F, Ricklin D, Wu J, Tzekou A, Wallace RS, Lambris JD, Gros P
Title Structures of C3b in complex with factors B and D give insight into complement convertase formation.
Related PDB 2xwb 2xwj
Related UniProtKB

Comments
This enzyme belongs to peptidase family-S1.
There are three types of activation of complement system: the classical pathway, the alternative pathway, or the lectin pathway (see [25]). The formation of C3-convertases is common to each pathway: C3bBb in the alternative pathway; C4b2a in the classical pathway/lectin pathway (see [25]). This enzyme corresponds to the C3-convertase in the alternative pathway.
This enzyme is composed of C-terminal fragment of complement factor B, Bb (residues 260-764 of uniprot;P00751), and C-terminal chain of complement factor C3, C3b (residues 749-1663 of uniprot;P01024) (see [21]). Bb contains catalytic domain of serine protease, whereas C3b is involved in covalent attachment to target surfaces. When Bb binds one unit of C3b to form C3bBb complex, this enzyme can activate C3 to produce C3a and C3b as C3 convertase. In contrast, this enzyme can also activate complement factor C5 to produce C5a and C5b as C5 convertase, if Bb binds two units of C3b to generate (C3b)2Bb complex.
Moreover, factor B is cleaved to generate Bb by factor D (EC 3.4.21.46; D00429 in EzCatDB), when it is in complex with complement subcomponent C3b or with cobra venom factor (see [21]). According to the literature [22], the cobra venom factor (Uniprot;Q91132) is a potent homologue of C3b that generates more stable convertases.
Since this enzyme has got the same catalytic site as trypsin, it must catalyze the trypsin-like reaction.

Created Updated
2011-05-09 2011-08-27