DB code: M00332

RLCP classification 3.103.130000.1162 : Transfer
CATH domain -.-.-.- :
2.60.40.10 : Immunoglobulin-like
2.60.40.10 : Immunoglobulin-like
2.60.40.10 : Immunoglobulin-like
2.60.40.10 : Immunoglobulin-like
-.-.-.- :
-.-.-.- :
3.30.200.20 : Phosphorylase Kinase; domain 1
1.10.510.10 : Transferase(Phosphotransferase); domain 1 Catalytic domain
-.-.-.- :
E.C. 2.7.10.1
CSA
M-CSA
MACiE

CATH domain Related DB codes (homologues)
1.10.510.10 : Transferase(Phosphotransferase); domain 1 M00125 M00124 M00131 T00224 M00127 M00129 M00130 M00132 M00136 M00196 M00197 M00198 M00304 M00323 M00325 M00326 M00327 M00328 M00329 M00330 M00331 M00333 M00335 M00339 M00344
2.60.40.10 : Immunoglobulin-like M00131 T00257 T00005 M00113 M00127 M00132 M00323 M00325 M00327 M00329 M00330 M00331 T00307 D00166 D00500 M00112 M00193 T00063 T00065 T00067 T00245
3.30.200.20 : Phosphorylase Kinase; domain 1 M00125 M00124 M00131 T00224 M00127 M00129 M00130 M00132 M00136 M00196 M00197 M00198 M00304 M00323 M00325 M00326 M00327 M00328 M00329 M00330 M00331 M00333 M00335 M00339 M00344 D00298

Uniprot Enzyme Name
UniprotKB Protein name Synonyms RefSeq MEROPS Pfam
Q12866 Tyrosine-protein kinase Mer
EC 2.7.10.1
Proto-oncogene c-Mer
Receptor tyrosine kinase MerTK
NP_006334.2 (Protein)
NM_006343.2 (DNA/RNA sequence)
I43.001 ()
PF00041 (fn3)
PF07679 (I-set)
PF07714 (Pkinase_Tyr)
[Graphical View]

KEGG enzyme name
Receptor protein-tyrosine kinase
ATP:protein-tyrosine O-phosphotransferase (ambiguous)
MER
MERTK
Protein-tyrosine kinase (ambiguous)
Protein tyrosine kinase (ambiguous)
Receptor protein tyrosine kinase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
Q12866 MERTK_HUMAN ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Interacts (upon activation) with TNK2, stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6 (By similarity). Interacts with VAV1 in a phosphotyrosine-independent manner. Membrane, Single-pass type I membrane protein (By similarity).

KEGG Pathways
Map code Pathways E.C.

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00305 C00002 C00585 C00008 C01167
E.C.
Compound Mg ATP [protein]-L-tyrosine ADP [protein]-L-tyrosine phosphate
Type divalent metal (Ca2+, Mg2+) amine group,nucleotide aromatic ring (only carbon atom),peptide/protein amine group,nucleotide aromatic ring (only carbon atom),peptide/protein,phosphate group/phosphate ion
ChEBI 18420
15422
16761
PubChem 888
5957
6022
2dbjA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
2p0cA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:ANP Unbound Unbound Unbound
2p0cB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:ANP Unbound Unbound Unbound
3bprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
3bprB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
3bprC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
3bprD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
3brbA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Bound:ADP Unbound
3brbB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Bound:ADP Unbound
2p0cA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound
2p0cB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound
3bprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
3bprB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
3bprC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
3bprD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound
3brbA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound
3brbB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
Literature [4] & Swiss-prot;Q12866

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
2dbjA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2p0cA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain invisible 596-597, 622-632, 658-664
2p0cB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain invisible 596-598, 622-632, 658-664
3bprA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain invisible 623-628, 662-666
3bprB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain invisible 624-630, 660-666
3bprC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain invisible 623-630, 663-666
3bprD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain invisible 623-630, 662-666
3brbA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain invisible 622-624, 659-665
3brbB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
2p0cA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASP 723;ARG 727 ASN 728;ASP 741 (Magnesium binding) invisible 745-762
2p0cB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASP 723;ARG 727 ASN 728;ASP 741 (Magnesium binding) invisible 745-762
3bprA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASP 723;ARG 727 ASN 728;ASP 741 (Magnesium binding) invisible 746-762
3bprB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASP 723;ARG 727 ASN 728;ASP 741 (Magnesium binding) invisible 746-762
3bprC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASP 723;ARG 727 ASN 728;ASP 741 (Magnesium binding) invisible 746-762
3bprD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASP 723;ARG 727 ASN 728;ASP 741 (Magnesium binding) invisible 746-762
3brbA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASP 723;ARG 727 ASN 728;ASP 741 (Magnesium binding) invisible 746-761
3brbB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ASP 723;ARG 727 ASN 728;ASP 741 (Magnesium binding) invisible 745-762

References for Catalytic Mechanism
References Sections No. of steps in catalysis

References
[1]
Resource
Comments
Medline ID
PubMed ID 8702477
Journal J Biol Chem
Year 1996
Volume 271
Pages 18355-62
Authors Ling L, Templeton D, Kung HJ
Title Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase.
Related PDB
Related UniProtKB
[2]
Resource
Comments
Medline ID
PubMed ID 9160883
Journal Oncogene
Year 1997
Volume 14
Pages 2033-9
Authors Chen J, Carey K, Godowski PJ
Title Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.
Related PDB
Related UniProtKB
[3]
Resource
Comments
Medline ID
PubMed ID 16737840
Journal Cytokine Growth Factor Rev
Year 2006
Volume 17
Pages 295-304
Authors Hafizi S, Dahlback B
Title Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.
Related PDB
Related UniProtKB
[4]
Resource
Comments
Medline ID
PubMed ID 19028587
Journal J Struct Biol
Year 2009
Volume 165
Pages 88-96
Authors Huang X, Finerty P Jr, Walker JR, Butler-Cole C, Vedadi M, Schapira M, Parker SA, Turk BE, Thompson DA, Dhe-Paganon S
Title Structural insights into the inhibited states of the Mer receptor tyrosine kinase.
Related PDB 2p0c 3bpr 3brb
Related UniProtKB Q12866

Comments
This enzyme belongs to Tyr protein kinase family.
The catalytic domain of this enzyme is homologous to that of vascular endothelial growth factor receptor (M00131 in EzCatDB).
The extracellular region of this enzyme is composed of two immunoglobulin (Ig) repeats and two fibronectin type three (Fn-III) repeats (see [2] and [3]).

Created Updated
2011-11-17 2012-12-11