DB code: S00033

RLCP classification 10.21100.110.10515 : Electron transfer
CATH domain 1.10.630.10 : Cytochrome p450 Catalytic domain
E.C. 1.14.15.1
CSA 1akd
M-CSA 1akd
MACiE M0133

CATH domain Related DB codes (homologues)
1.10.630.10 : Cytochrome p450 S00031 M00154 S00030

Uniprot Enzyme Name
UniprotKB Protein name Synonyms Pfam
P00183 Camphor 5-monooxygenase
EC 1.14.15.1
Cytochrome P450-cam
Cytochrome P450cam
PF00067 (p450)
[Graphical View]

KEGG enzyme name
camphor 5-monooxygenase
camphor 5-exo-methylene hydroxylase
2-bornanone 5-exo-hydroxylase
bornanone 5-exo-hydroxylase
camphor 5-exo-hydroxylase
camphor 5-exohydroxylase
camphor hydroxylase
d-camphor monooxygenase
methylene hydroxylase
methylene monooxygenase
D-camphor-exo-hydroxylase
camphor methylene hydroxylase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P00183 CPXA_PSEPU (+)-camphor + putidaredoxin + O(2) = (+)-exo- 5-hydroxycamphor + oxidized putidaredoxin + H(2)O. Cytoplasm (By similarity). Heme group.

KEGG Pathways
Map code Pathways E.C.

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00032 C00808 C02069 C00007 C03448 C03302 C00001
E.C. (Ferric superoxy form)
(1-)
(Ferric peroxoanion form)
(2-)
(Ferric hydroperoxo form)
(1-)
(Compound I)
Compound Heme (+)-Camphor Putidaredoxin O2 (+)-exo-5-Hydroxycamphor Oxidized putidaredoxin H2O FeIII-O-O FeIII-O-O FeIII-O-OH FeIV=O
Type aromatic ring (with nitrogen atoms),carboxyl group,heavy metal carbohydrate heavy metal,peptide/protein,sulfide group others carbohydrate heavy metal,peptide/protein,sulfide group H2O
ChEBI 17627
26355
15379
26689
27140
20570
15377
PubChem 9543187
977
440017
22247451
962
1akdA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1c8jA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
1c8jB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
1cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-BNZ Unbound Unbound Unbound Unbound Unbound
1dz4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1dz4B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1dz6A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1dz6B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1dz8A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Bound:OXY Unbound Unbound
1dz8B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1dz9A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound Bound:__O
1dz9B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound Unbound
1gebA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1gekA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-NBN Unbound Unbound Unbound Unbound Unbound
1gemA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-NBN Unbound Unbound Unbound Unbound Unbound
1gjmA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
1iwiA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1iwjA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1iwkA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
1j51A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:TCZ Unbound Unbound Unbound Unbound
1j51B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:TCZ Unbound Unbound Unbound Unbound
1j51C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:TCZ Unbound Unbound Unbound Unbound
1j51D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
1k2oA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:RFA-RFB Unbound Unbound Unbound Unbound
1k2oB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:RFA-RFB Unbound Unbound Unbound Unbound
1lwlA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:DSO Unbound Unbound Unbound Unbound
1mpwA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Analogue:TMH Unbound
1mpwB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Analogue:TMH Unbound
1nooA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Bound:CAH Unbound
1o76A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Analogue:CYN Unbound Unbound
1o76B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Analogue:CYN Unbound Unbound
1p2yA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-NCT Unbound Unbound Unbound Unbound Unbound
1p7rA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:NCT Unbound Unbound Unbound Unbound
1phaA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-PFZ Unbound Unbound Unbound Unbound Unbound
1phbA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-PFZ Unbound Unbound Unbound Unbound Unbound
1phcA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
1phdA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-PIM Unbound Unbound Unbound Unbound Unbound
1pheA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:PIM Unbound Unbound Unbound Unbound Analogue:SO4
1phfA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-PIM Unbound Unbound Unbound Unbound Unbound
1phgA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-MYT Unbound Unbound Unbound Unbound Unbound
1qmqA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:LRB-DRB Unbound Unbound Unbound Unbound
1re9A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:DSO Unbound Unbound Unbound Unbound
1rf9A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:DBR Unbound Unbound Unbound Unbound
1t85A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Analogue:CMO Unbound Unbound
1t86A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1t86B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1t87A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1t87B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Analogue:CMO Unbound Unbound
1t88A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1t88B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1uyuA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1uyuB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1yrcA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
1yrdA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
2a1mA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Bound:OXY Unbound Unbound
2a1mB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Bound:OXY Unbound Unbound
2a1nA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Bound:OXY Unbound Unbound
2a1nB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Bound:OXY Unbound Unbound
2a1oA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Bound:OXY Unbound Unbound
2a1oB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Bound:OXY Unbound Unbound
2cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
2cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
2fe6A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:MNR Unbound Unbound Unbound Unbound Unbound
2ferA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:MNR Unbound Unbound Unbound Unbound Unbound
2feuA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:MNR Bound:CAM Unbound Unbound Unbound Unbound
2feuB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:MNR Bound:CAM Unbound Unbound Unbound Unbound
2frzA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
2frzB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
2gqxA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:5CL Unbound Unbound Unbound Unbound
2gqxB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
2gr6A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
2gr6B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
2h7qA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-IMD Unbound Unbound Unbound Unbound Unbound
2h7rA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:HEM-1MZ Unbound Unbound Unbound Unbound Unbound
2h7sA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
2h7sC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Unbound Unbound
2qblA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
2qbmA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Analogue:CYN Unbound Unbound
2qbnA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
2qboA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Analogue:CYN Unbound Unbound
2zawA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:6HE Bound:CAM Unbound Unbound Unbound Unbound
2zaxA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
3cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:ADM Unbound Unbound Unbound Unbound
3cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Analogue:CMO Unbound Unbound
4cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
4cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:ADM Unbound Unbound Unbound Unbound
5cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
5cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:ADO Unbound Unbound Unbound Unbound
6cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Bound:CAM Unbound Unbound Unbound Unbound
6cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:CAE Unbound Unbound Unbound Unbound
7cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Analogue:NCM Unbound Unbound Unbound Unbound
8cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:HEM Unbound Unbound Unbound Analogue:TCM Unbound

Reference for Active-site residues
resource references E.C.
literature [9], [11], [30], [37]

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1akdA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1c8jA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87W, Y96F
1c8jB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87W, Y96F
1cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1dz4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1dz4B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1dz6A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1dz6B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1dz8A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1dz8B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1dz9A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1dz9B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1gebA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251; CYS 357(Iron binding) mutant T252I
1gekA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1gemA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1gjmA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1iwiA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1iwjA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant R109K
1iwkA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant R112K
1j51A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87Y, Y96F, V247L, C334A
1j51B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87Y, Y96F, V247L, C334A
1j51C Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87Y, Y96F, V247L, C334A
1j51D Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87Y, Y96F, V247L, C334A
1k2oA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutation C334A
1k2oB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutation C334A
1lwlA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1mpwA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87W, Y96F, V247L, C334A
1mpwB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87W, Y96F, V247L, C334A
1nooA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1o76A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1o76B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1p2yA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1p7rA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1phaA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1phbA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1phcA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1phdA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1pheA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1phfA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1phgA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1qmqA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant C334A
1re9A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 102;LYS 168;ARG 176;ASP 241;THR 242 CYS 347(Iron binding)
1rf9A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1t85A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant C334A, L358P
1t86A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant C334A, L358P
1t86B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant C334A, L358P
1t87A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant C334A
1t87B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant C334A
1t88A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant C334A
1t88B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant C334A
1uyuA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1uyuB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1yrcA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
1yrdA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
2a1mA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
2a1mB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
2a1nA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;;THR 252 CYS 357(Iron binding) mutant D251N
2a1nB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;;THR 252 CYS 357(Iron binding) mutant D251N
2a1oA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251; CYS 357(Iron binding) mutant T252A
2a1oB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251; CYS 357(Iron binding) mutant T252A
2cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251; CYS 357(Iron binding) mutant T252A
2cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
2fe6A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
2ferA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
2feuA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
2feuB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
2frzA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87W, Y96F, V247L, C334A
2frzB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87W, Y96F, V247L, C334A
2gqxA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87W, Y96F, L244A, V247L, C334A
2gqxB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87W, Y96F, L244A, V247L, C334A
2gr6A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87W, Y96F, L244A, V247L, C334A
2gr6B Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant F87W, Y96F, L244A, V247L, C334A
2h7qA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
2h7rA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant L244A
2h7sA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant L244A
2h7sC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant L244A
2qblA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant G248T
2qbmA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant G248T
2qbnA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant G248V
2qboA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding) mutant G248V
2zawA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
2zaxA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
3cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
3cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
4cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
4cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
5cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
5cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
6cp4A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;;THR 252 CYS 357(Iron binding) mutant D251N
6cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
7cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)
8cppA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 112;LYS 178;ARG 186;ASP 251;THR 252 CYS 357(Iron binding)

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[1]
p.16129
[8]
p.7590-7591
[11]
Fig.1, p.11426-11428
[12]
p.2680
[17]
Fig.1, Fig.3, p.677-678
[21]
Fig.1, p.1179-1182
[25]
Fig.10, p.1076
[30]
p.9216-9218, Fig.10
[31]
p.166
[32]
Fig.1, p.176-177
[37]
p.972-973, Fig.6
[40]
[41]
Fig.1, p.1617-1621
[42]
Fig.1
[52]
p.14512-14513
[54]
Fig.4
[55]
p.31662-31663
[58]
Fig.1, p.508-514
[60]
Scheme 1, p.477-479
[61]
Fig.1, p.14136-14139

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Related UniProtKB P00183
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Related UniProtKB
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Related UniProtKB
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Related UniProtKB
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Related UniProtKB
[12]
Resource
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Medline ID
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Related PDB 4cpp 6cpp 8cpp
Related UniProtKB
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Medline ID
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Related UniProtKB
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Comments
Medline ID
PubMed ID 1749772
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Year 1991
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Title A 175-psec molecular dynamics simulation of camphor-bound cytochrome P-450cam.
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Related UniProtKB
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Medline ID
PubMed ID 1449498
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Related PDB
Related UniProtKB
[16]
Resource
Comments CIRCULAR DICHROISM SPECTROSCOPY
Medline ID 92305023
PubMed ID 1610873
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Related UniProtKB P00183
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Medline ID
PubMed ID 1537455
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Related UniProtKB
[18]
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Medline ID
PubMed ID 8485133
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Related PDB 1pha 1phb
Related UniProtKB
[19]
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Comments
Medline ID
PubMed ID 8332592
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Related PDB
Related UniProtKB
[20]
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Comments
Medline ID
PubMed ID 8034004
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Year 1994
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Related UniProtKB
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Medline ID
PubMed ID 8120894
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Related UniProtKB
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Comments
Medline ID
PubMed ID 7700866
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Related UniProtKB
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Medline ID
PubMed ID 8519982
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Related UniProtKB
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Medline ID
PubMed ID 8637849
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Related UniProtKB
[25]
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Medline ID
PubMed ID 7549871
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Related UniProtKB
[26]
Resource
Comments STRUCTURE BY NMR
Medline ID 97459726
PubMed ID 9315686
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Related UniProtKB P00183
[27]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS)
Medline ID 98019009
PubMed ID 9357977
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Related UniProtKB P00183
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Comments
Medline ID
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Related UniProtKB
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Medline ID
PubMed ID 9761931
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Related PDB
Related UniProtKB
[30]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)
Medline ID 98313255
PubMed ID 9649301
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Year 1998
Volume 37
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Authors Vidakovic M, Sligar SG, Li H, Poulos TL
Title Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect.
Related PDB 5cp4 6cp4
Related UniProtKB P00183
[31]
Resource
Comments
Medline ID
PubMed ID 9675266
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Year 1998
Volume 1386
Pages 157-67
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Related PDB
Related UniProtKB
[32]
Resource
Comments
Medline ID
PubMed ID 9675270
Journal Biochim Biophys Acta
Year 1998
Volume 1386
Pages 168-78
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Related PDB
Related UniProtKB
[33]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
Medline ID
PubMed ID
Journal J Am Chem Soc
Year 1998
Volume 120
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Title Covalent attachment of an electroactive sulfydryl reagent in the active site of cytochrome P450cam as revealed by the crystal structure of the modified protein.
Related PDB 1gjm
Related UniProtKB P00183
[34]
Resource
Comments
Medline ID
PubMed ID 9888815
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Year 1999
Volume 38
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Related PDB
Related UniProtKB
[35]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS)
Medline ID 20027486
PubMed ID 10557259
Journal Proc Natl Acad Sci U S A
Year 1999
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Related PDB 1qmq
Related UniProtKB P00183
[36]
Resource
Comments
Medline ID
PubMed ID 10601869
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Year 2000
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Title Assignment of heme methyl 1H-NMR resonances of high-spin and low-spin ferric complexes of cytochrome p450cam using one-dimensional and two-dimensional paramagnetic signals enhancement (PASE) magnetization transfer experiments.
Related PDB
Related UniProtKB
[37]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS)
Medline ID 21062556
PubMed ID 11098139
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Related UniProtKB P00183
[38]
Resource
Comments
Medline ID
PubMed ID 11051557
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Related PDB
Related UniProtKB
[39]
Resource
Comments
Medline ID
PubMed ID 11051567
Journal J Inorg Biochem
Year 2000
Volume 81
Pages 221-8
Authors Dmochowski IJ, Winkler JR, Gray HB
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Related PDB
Related UniProtKB
[40]
Resource
Comments
Medline ID
PubMed ID 10742167
Journal Nat Struct Biol
Year 2000
Volume 7
Pages 270
Authors Feng HP
Title Picture story. Freeze frame.
Related PDB
Related UniProtKB
[41]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)
Medline ID 20165028
PubMed ID 10698731
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Year 2000
Volume 287
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Authors Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG
Title The catalytic pathway of cytochrome p450cam at atomic resolution.
Related PDB 1dz4 1dz6 1dz8 1dz9
Related UniProtKB P00183
[42]
Resource
Comments
Medline ID
PubMed ID 11583152
Journal Biochemistry
Year 2001
Volume 40
Pages 9532-8
Authors French KJ, Strickler MD, Rock DA, Rock DA, Bennett GA, Wahlstrom JL, Goldstein BM, Jones JP
Title Benign synthesis of 2-ethylhexanoic acid by cytochrome P450cam: enzymatic, crystallographic, and theoretical studies.
Related PDB
Related UniProtKB
[43]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS)
Medline ID 21159060
PubMed ID 11258878
Journal Biochemistry
Year 2001
Volume 40
Pages 2669-77
Authors Lee DS, Park SY, Yamane K, Obayashi E, Hori H, Shiro Y
Title Structural characterization of n-butyl-isocyanide complexes of cytochromes P450nor and P450cam.
Related PDB 1gek 1gem
Related UniProtKB P00183
[44]
Resource
Comments
Medline ID
PubMed ID 11688945
Journal J Comput Aided Mol Des
Year 2001
Volume 15
Pages 649-57
Authors Keseru GM
Title A virtual high throughput screen for high affinity cytochrome P450cam substrates. Implications for in silico prediction of drug metabolism.
Related PDB
Related UniProtKB
[45]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS)
Medline ID 21532932
PubMed ID 11606730
Journal Proc Natl Acad Sci U S A
Year 2001
Volume 98
Pages 12420-5
Authors Dunn AR, Dmochowski IJ, Bilwes AM, Gray HB, Crane BR
Title Probing the open state of cytochrome P450cam with ruthenium-linker substrates.
Related PDB 1k2o
Related UniProtKB P00183
[46]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12197708
Journal J Am Chem Soc
Year 2002
Volume 124
Pages 10254-5
Authors Dunn AR, Hays AM, Goodin DB, Stout CD, Chiu R, Winkler JR, Gray HB
Title Fluorescent probes for cytochrome p450 structural characterization and inhibitor screening.
Related PDB 1lwl
Related UniProtKB
[47]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12114516
Journal J Biol Chem
Year 2002
Volume 277
Pages 37519-26
Authors Chen X, Christopher A, Jones JP, Bell SG, Guo Q, Xu F, Rao Z, Wong LL
Title Crystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzene.
Related PDB 1j51
Related UniProtKB
[48]
Resource
Comments SUBSTRATE-PROTEIN INTERACTION
Medline ID 22222631
PubMed ID 12237225
Journal J Inorg Biochem
Year 2002
Volume 91
Pages 597-606
Authors Deprez E, Gill E, Helms V, Wade RC, Hui Bon Hoa G
Title Specific and non-specific effects of potassium cations on substrate-protein interactions in cytochromes P450cam and P450lin.
Related PDB
Related UniProtKB P00183
[49]
Resource
Comments
Medline ID
PubMed ID 12211002
Journal Proteins
Year 2002
Volume 49
Pages 216-31
Authors Kirton SB, Kemp CA, Tomkinson NP, St-Gallay S, Sutcliffe MJ
Title Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.
Related PDB
Related UniProtKB
[50]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID
Journal Arch Biochem Biophys
Year 2003
Volume 409
Pages 25-31
Authors Fedorov R, Ghosh DK, Schlichting I
Title Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase-structural models of the short-lived oxygen complexes.
Related PDB 1o76
Related UniProtKB
[51]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 14556625
Journal Biochemistry
Year 2003
Volume 42
Pages 11943-50
Authors Strickler M, Goldstein BM, Maxfield K, Shireman L, Kim G, Matteson DS, Jones JP
Title Crystallographic studies on the complex behavior of nicotine binding to P450cam (CYP101).
Related PDB 1p2y 1p7r
Related UniProtKB
[52]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 14661963
Journal Biochemistry
Year 2003
Volume 42
Pages 14507-14
Authors Nagano S, Shimada H, Tarumi A, Hishiki T, Kimata-Ariga Y, Egawa T, Suematsu M, Park SY, Adachi S, Shiro Y, Ishimura Y
Title Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam.
Related PDB 1iwi 1iwj 1iwk
Related UniProtKB
[53]
Resource
Comments
Medline ID
PubMed ID 15522298
Journal J Mol Biol
Year 2004
Volume 344
Pages 455-69
Authors Hays AM, Dunn AR, Chiu R, Gray HB, Stout CD, Goodin DB
Title Conformational states of cytochrome P450cam revealed by trapping of synthetic molecular wires.
Related PDB 1re9 1rf9
Related UniProtKB
[54]
Resource
Comments
Medline ID
PubMed ID 15269210
Journal J Biol Chem
Year 2004
Volume 279
Pages 42844-9
Authors Nagano S, Tosha T, Ishimori K, Morishima I, Poulos TL
Title Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding.
Related PDB 1t85 1t86 1t87 1t88
Related UniProtKB
[55]
Resource
Comments
Medline ID
PubMed ID 15219983
Journal J Inorg Biochem
Year 2004
Volume 98
Pages 1175-82
Authors Wade RC, Winn PJ, Schlichting I, Sudarko
Title A survey of active site access channels in cytochromes P450.
Related PDB 1uyu
Related UniProtKB
[56]
Resource
Comments
Medline ID
PubMed ID 15858263
Journal Acta Crystallogr D Biol Crystallogr
Year 2005
Volume 61
Pages 539-44
Authors Meilleur F, Dauvergne MT, Schlichting I, Myles DA
Title Production and X-ray crystallographic analysis of fully deuterated cytochrome P450cam.
Related PDB 1yrc 1yrd
Related UniProtKB
[57]
Resource
Comments
Medline ID
PubMed ID 15994329
Journal J Biol Chem
Year 2005
Volume 280
Pages 31659-63
Authors Nagano S, Poulos TL
Title Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism.
Related PDB 2a1m 2a1n 2a1o
Related UniProtKB
[58]
Resource
Comments
Medline ID
PubMed ID 16510191
Journal J Inorg Biochem
Year 2006
Volume 100
Pages 507-18
Authors Makris TM, von Koenig K, Schlichting I, Sligar SG
Title The status of high-valent metal oxo complexes in the P450 cytochromes.
Related PDB 2fe6 2fer 2feu
Related UniProtKB
[59]
Resource
Comments
Medline ID
PubMed ID 16943206
Journal Protein Eng Des Sel
Year 2006
Volume 19
Pages 491-6
Authors Verras A, Alian A, de Montellano PR
Title Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450(cam) by an L244A mutation.
Related PDB 2h7q 2h7r 2h7s
Related UniProtKB
[60]
Resource
Comments
Medline ID
PubMed ID 17962225
Journal Protein Eng Des Sel
Year 2007
Volume 20
Pages 473-80
Authors Xu F, Bell SG, Rao Z, Wong LL
Title Structure-activity correlations in pentachlorobenzene oxidation by engineered cytochrome P450cam.
Related PDB 2frz 2gqz 2gr6
Related UniProtKB
[61]
Resource
Comments
Medline ID
PubMed ID 18001135
Journal Biochemistry
Year 2007
Volume 46
Pages 14129-40
Authors Makris TM, von Koenig K, Schlichting I, Sligar SG
Title Alteration of P450 distal pocket solvent leads to impaired proton delivery and changes in heme geometry.
Related PDB 2qbl 2qbm 2qbn 2qbo
Related UniProtKB
[62]
Resource
Comments
Medline ID
PubMed ID 18088124
Journal J Am Chem Soc
Year 2008
Volume 130
Pages 432-3
Authors Harada K, Sakurai K, Ikemura K, Ogura T, Hirota S, Shimada H, Hayashi T
Title Evaluation of the functional role of the heme-6-propionate side chain in cytochrome P450cam.
Related PDB 2zaw 2zax
Related UniProtKB

Comments
Putidaredoxin (PDB;1oqq) is a electron-transfer protein from Pseudomonas putida, which is homologous to ferredoxin (PDB;1a70), with [2Fe-2S] as a cofactor. This enzyme accepts one electron at a time from putidaredoxin, indicating that the two association-dissociation interactions between this enzyme and putidaredoxin occur.
(A) Electron transfer from [2Fe-2S] (of putidaredoxin) to heme group of this enzyme, reducing the heme-iron from the ferric (FeIII) to the ferrous state (FeII):
(A1) Indirect transfer from [2Fe-2S] to Asp38 through Cys39 (bound to [2Fe-2S]) (of putidaredoxin).
(A2) Indirect transfer from Asp38 (of putidaredoxin) to Heme propionate group (acidic group) through Arg112 (of this enzyme) (see [31]).
(C) Electron transfer from [2Fe-2S] (of putidaredoxin) to heme group of this enzyme, decomposing the oxygenated intermediate:
The following reactions involve proton shuttle through Lys178, Arg186, Asp251, Thr252 (see [37], [41]).
(B) Oxygenation of camphor by O2 at heme, giving 5-hydroxycamphor and water (H2O):
(B1) Peroxygenation step from O2 to produce O-OH:
(B2) Water(H2O) release from the active site:
(B3) Hydroxylation step of camphor:

Created Updated
2004-10-21 2009-02-26