DB code: S00221

CATH domain 3.20.20.70 : TIM Barrel Catalytic domain
E.C. 4.1.1.23
CSA 1eix 1dbt
M-CSA 1eix 1dbt
MACiE M0050

CATH domain Related DB codes (homologues)
3.20.20.70 : TIM Barrel S00215 S00217 S00218 S00219 S00532 S00198 S00220 S00745 S00537 S00538 S00539 S00826 S00841 S00235 S00239 S00240 S00243 S00244 S00199 S00200 S00201 S00222 S00847 S00224 S00225 S00226 D00014 D00029 M00141 T00015 T00239 D00664 D00665 D00804 D00863 T00089

Uniprot Enzyme Name
UniprotKB Protein name Synonyms RefSeq Pfam
O26232 Orotidine 5''-phosphate decarboxylase
EC 4.1.1.23
OMP decarboxylase
OMPDCase
OMPdecase
NP_275272.1 (Protein)
NC_000916.1 (DNA/RNA sequence)
PF00215 (OMPdecase)
[Graphical View]
P03962 Orotidine 5''-phosphate decarboxylase
EC 4.1.1.23
OMP decarboxylase
OMPDCase
OMPdecase
Uridine 5''-monophosphate synthase
UMP synthase
NP_010893.3 (Protein)
NM_001178836.3 (DNA/RNA sequence)
PF00215 (OMPdecase)
[Graphical View]
P25971 Orotidine 5''-phosphate decarboxylase
EC 4.1.1.23
OMP decarboxylase
OMPDCase
OMPdecase
NP_389438.1 (Protein)
NC_000964.3 (DNA/RNA sequence)
PF00215 (OMPdecase)
[Graphical View]
P08244 Orotidine 5''-phosphate decarboxylase
EC 4.1.1.23
OMP decarboxylase
OMPDCase
OMPdecase
NP_415797.1 (Protein)
NC_000913.2 (DNA/RNA sequence)
YP_489549.1 (Protein)
NC_007779.1 (DNA/RNA sequence)
PF00215 (OMPdecase)
[Graphical View]

KEGG enzyme name
orotidine-5'-phosphate decarboxylase
orotidine-5'-monophosphate decarboxylase
orotodylate decarboxylase
orotidine phosphate decarboxylase
OMP decarboxylase
orotate monophosphate decarboxylase
orotidine monophosphate decarboxylase
orotidine phosphate decarboxylase
OMP-DC
orotate decarboxylase
orotidine 5'-phosphate decarboxylase
orotidylic decarboxylase
orotidylic acid decarboxylase
orotodylate decarboxylase
ODCase
orotic decarboxylase
orotidine-5'-phosphate carboxy-lyase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
O26232 PYRF_METTH Orotidine 5''-phosphate = UMP + CO(2). Homodimer.
P03962 PYRF_YEAST Orotidine 5''-phosphate = UMP + CO(2).
P25971 PYRF_BACSU Orotidine 5''-phosphate = UMP + CO(2). Homodimer.
P08244 PYRF_ECOLI Orotidine 5''-phosphate = UMP + CO(2). Homodimer.

KEGG Pathways
Map code Pathways E.C.
MAP00240 Pyrimidine metabolism

Compound table
Substrates Products Intermediates
KEGG-id C01103 C00105 C00011
E.C.
Compound Orotidine 5'-phosphate UMP CO2 literature
Type amide group,carbohydrate,nucleotide amide group,nucleotide others [18]
ChEBI 15842
16695
16526
PubChem 160617
6030
280
1dbtA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:U5P Unbound Unbound
1dbtB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:U5P Unbound Unbound
1dbtC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:U5P Unbound Unbound
1dqwA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1dqwB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1dqwC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1dqwD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1dqxA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1dqxB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1dqxC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1dqxD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1dv7A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1dvjA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:UP6 Unbound Unbound
1dvjB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:UP6 Unbound Unbound
1dvjC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:UP6 Unbound Unbound
1dvjD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Analogue:UP6 Unbound Unbound
1eixA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:BMQ Unbound Unbound Unbound
1eixB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:BMQ Unbound Unbound Unbound
1eixC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:BMQ Unbound Unbound Unbound
1eixD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:BMQ Unbound Unbound Unbound
1jjkA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkF Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkG Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkI Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkK Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkM Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkN Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkO Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1jjkP Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Transition-state-analogue:BMP
1l2uA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound
1l2uB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
Swiss-prot;O26232, P03962, P25971

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1dbtA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 62
1dbtB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 62
1dbtC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 62
1dqwA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 93
1dqwB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 93
1dqwC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 93
1dqwD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 93
1dqxA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 93
1dqxB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 93
1dqxC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 93
1dqxD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 93
1dv7A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 72
1dvjA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 72
1dvjB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 72
1dvjC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 72
1dvjD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 72
1eixA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1eixB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1eixC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1eixD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkF Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkG Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkI Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkK Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkM Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkN Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkO Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1jjkP Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1l2uA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73
1l2uB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain LYS 73

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[6]
p.12167-12168
[7]
p.336-341
[9]
[11]
Fig.6, Fig.7, p.4222-4224 2
[12]
p.8116-8117
[14]
Fig.3, Fig.4, Fig.5, p.4572-4574
[15]
p.14731-14733
[16]
Fig.2, p.714-716
[17]
Scheme 1, Fig.7, p.2009-2010 2
[18]
Fig.7, p.2014-2016 3
[19]
Scheme II, p.2020-2022 3
[20]
[22]
Fig.1, Fig.2, p.104-105
[23]
Scheme 3, Scheme 4, p.114-118
[24]
Fig.12, p.12846-12848
[26]
Fig.8, p.863-874
[32]
Fig. 1 p.268

References
[1]
Resource
Comments
Medline ID
PubMed ID 6894094
Journal Biochemistry
Year 1980
Volume 19
Pages 6068-74
Authors Traut TW, Payne RC
Title Dependence of the catalytic activities on the aggregation and conformation states of uridine 5'-phosphate synthase.
Related PDB
Related UniProtKB
[2]
Resource
Comments
Medline ID
PubMed ID 6894093
Journal Biochemistry
Year 1980
Volume 19
Pages 6062-8
Authors Traut TW, Payne RC, Jones ME
Title Dependence of the aggregation and conformation states of uridine 5'-phosphate synthase on pyrimidine nucleotides. Evidence for a regulatory site.
Related PDB
Related UniProtKB
[3]
Resource
Comments
Medline ID
PubMed ID 2334689
Journal Biochemistry
Year 1990
Volume 29
Pages 3198-202
Authors Acheson SA, Bell JB, Jones ME, Wolfenden R
Title Orotidine-5'-monophosphate decarboxylase catalysis: kinetic isotope effects and the state of hybridization of a bound transition-state analogue.
Related PDB
Related UniProtKB
[4]
Resource
Comments
Medline ID
PubMed ID 2008434
Journal Proteins
Year 1991
Volume 9
Pages 143-51
Authors Bell JB, Jones ME, Carter CW Jr
Title Crystallization of yeast orotidine 5'-monophosphate decarboxylase complexed with 1-(5'-phospho-beta-D-ribofuranosyl) barbituric acid.
Related PDB
Related UniProtKB
[5]
Resource
Comments
Medline ID
PubMed ID 1457411
Journal Biochemistry
Year 1992
Volume 31
Pages 12155-61
Authors Shostak K, Jones ME
Title Orotidylate decarboxylase: insights into the catalytic mechanism from substrate specificity studies.
Related PDB
Related UniProtKB
[6]
Resource
Comments
Medline ID
PubMed ID 1457412
Journal Biochemistry
Year 1992
Volume 31
Pages 12162-8
Authors Smiley JA, Jones ME
Title A unique catalytic and inhibitor-binding role for Lys93 of yeast orotidylate decarboxylase.
Related PDB
Related UniProtKB
[7]
Resource
Comments
Medline ID
PubMed ID 1499340
Journal Curr Top Cell Regul
Year 1992
Volume 33
Pages 331-42
Authors Jones ME
Title Orotidylate decarboxylase of yeast and man.
Related PDB
Related UniProtKB
[8]
Resource
Comments
Medline ID
PubMed ID 8631878
Journal J Biol Chem
Year 1996
Volume 271
Pages 10704-8
Authors Yablonski MJ, Pasek DA, Han BD, Jones ME, Traut TW
Title Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase.
Related PDB
Related UniProtKB
[9]
Resource
Comments
Medline ID
PubMed ID 9139656
Journal Science
Year 1997
Volume 276
Pages 942-5
Authors Lee JK, Houk KN
Title A proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylase.
Related PDB
Related UniProtKB
[10]
Resource
Comments
Medline ID
PubMed ID 10334928
Journal Biochem Biophys Res Commun
Year 1999
Volume 259
Pages 133-5
Authors Cui W, DeWitt JG, Miller SM, Wu W
Title No metal cofactor in orotidine 5'-monophosphate decarboxylase.
Related PDB
Related UniProtKB
[11]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 10757968
Journal Biochemistry
Year 2000
Volume 39
Pages 4217-24
Authors Harris P, Navarro Poulsen JC, Jensen KF, Larsen S
Title Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase.
Related PDB 1eix
Related UniProtKB
[12]
Resource
Comments
Medline ID
PubMed ID 10889016
Journal Biochemistry
Year 2000
Volume 39
Pages 8113-8
Authors Miller BG, Snider MJ, Short SA, Wolfenden R
Title Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5'-phosphate decarboxylase.
Related PDB
Related UniProtKB
[13]
Resource
Comments
Medline ID
PubMed ID 10995247
Journal Biochemistry
Year 2000
Volume 39
Pages 11788-800
Authors Porter DJ, Short SA
Title Yeast orotidine-5'-phosphate decarboxylase: steady-state and pre-steady-state analysis of the kinetic mechanism of substrate decarboxylation.
Related PDB
Related UniProtKB
[14]
Resource
Comments
Medline ID
PubMed ID 10769111
Journal Biochemistry
Year 2000
Volume 39
Pages 4569-74
Authors Rishavy MA, Cleland WW
Title Determination of the mechanism of orotidine 5'-monophosphate decarboxylase by isotope effects.
Related PDB
Related UniProtKB
[15]
Resource
Comments
Medline ID
PubMed ID 11101287
Journal Biochemistry
Year 2000
Volume 39
Pages 14728-38
Authors Warshel A, Strajbl M, Villa J, Florian J
Title Remarkable rate enhancement of orotidine 5'-monophosphate decarboxylase is due to transition-state stabilization rather than to ground-state destabilization.
Related PDB
Related UniProtKB
[16]
Resource
Comments
Medline ID
PubMed ID 11114509
Journal Curr Opin Struct Biol
Year 2000
Volume 10
Pages 711-8
Authors Begley TP, Appleby TC, Ealick SE
Title The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase.
Related PDB
Related UniProtKB
[17]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 10681442
Journal Proc Natl Acad Sci U S A
Year 2000
Volume 97
Pages 2005-10
Authors Appleby TC, Kinsland C, Begley TP, Ealick SE
Title The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase.
Related PDB 1dbt
Related UniProtKB
[18]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
Medline ID 20160896
PubMed ID 10681417
Journal Proc Natl Acad Sci U S A
Year 2000
Volume 97
Pages 2011-6
Authors Miller BG, Hassell AM, Wolfenden R, Milburn MV, Short SA
Title Anatomy of a proficient enzyme: the structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog.
Related PDB 1dqw 1dqx
Related UniProtKB P03962
[19]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
Medline ID 20160897
PubMed ID 10681441
Journal Proc Natl Acad Sci U S A
Year 2000
Volume 97
Pages 2017-22
Authors Wu N, Mo Y, Gao J, Pai EF
Title Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase.
Related PDB 1dv7 1dvj
Related UniProtKB O26232
[20]
Resource
Comments
Medline ID
PubMed ID 11526316
Journal Acta Crystallogr D Biol Crystallogr
Year 2001
Volume 57
Pages 1251-9
Authors Poulsen JC, Harris P, Jensen KF, Larsen S
Title Selenomethionine substitution of orotidine-5'-monophosphate decarboxylase causes a change in crystal contacts and space group.
Related PDB 1jjk
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID 11371183
Journal Biochemistry
Year 2001
Volume 40
Pages 6227-32
Authors Miller BG, Butterfoss GL, Short SA, Wolfenden R
Title Role of enzyme-ribofuranosyl contacts in the ground state and transition state for orotidine 5'-phosphate decarboxylase: a role for substrate destabilization?
Related PDB
Related UniProtKB
[22]
Resource
Comments
Medline ID
PubMed ID 11300698
Journal Bioorg Chem
Year 2001
Volume 29
Pages 96-106
Authors Smiley JA, Hay KM, Levison BS
Title A reexamination of the substrate utilization of 2-thioorotidine-5'-monophosphate by yeast orotidine-5'-monophosphate decarboxylase.
Related PDB
Related UniProtKB
[23]
Resource
Comments
Medline ID
PubMed ID 11828434
Journal Chembiochem
Year 2001
Volume 2
Pages 113-8
Authors Houk KN, Lee JK, Tantillo DJ, Bahmanyar S, Hietbrink BN
Title Crystal structures of orotidine monophosphate decarboxylase: does the structure reveal the mechanism of nature's most proficient enzyme?
Related PDB
Related UniProtKB
[24]
Resource
Comments
Medline ID
PubMed ID 11749542
Journal J Am Chem Soc
Year 2001
Volume 123
Pages 12837-48
Authors Lee TS, Chong LT, Chodera JD, Kollman PA
Title An alternative explanation for the catalytic proficiency of orotidine 5'-phosphate decarboxylase.
Related PDB
Related UniProtKB
[25]
Resource
Comments
Medline ID
PubMed ID 11278904
Journal J Biol Chem
Year 2001
Volume 276
Pages 15174-6
Authors Miller BG, Snider MJ, Wolfenden R, Short SA
Title Dissecting a charged network at the active site of orotidine-5'-phosphate decarboxylase.
Related PDB
Related UniProtKB
[26]
Resource
Comments
Medline ID
PubMed ID 12045113
Journal Annu Rev Biochem
Year 2002
Volume 71
Pages 847-85
Authors Miller BG, Wolfenden R
Title Catalytic proficiency: the unusual case of OMP decarboxylase.
Related PDB
Related UniProtKB
[27]
Resource
Comments
Medline ID
PubMed ID 11900527
Journal Biochemistry
Year 2002
Volume 41
Pages 3861-9
Authors Wise E, Yew WS, Babbitt PC, Gerlt JA, Rayment I
Title Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase.
Related PDB
Related UniProtKB
[28]
Resource
Comments
Medline ID
PubMed ID 11900543
Journal Biochemistry
Year 2002
Volume 41
Pages 4002-11
Authors Wu N, Gillon W, Pai EF
Title Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography.
Related PDB
Related UniProtKB
[29]
Resource
Comments
Medline ID
PubMed ID 12430437
Journal Chem Commun (Camb)
Year 2002
Volume (20)
Pages 2354-5
Authors Kurinovich MA, Phillips LM, Sharma S, Lee JK
Title The gas phase proton affinity of uracil: measuring multiple basic sites and implications for the enzyme mechanism of orotidine 5'-monophosphate decarboxylase.
Related PDB
Related UniProtKB
[30]
Resource
Comments
Medline ID
PubMed ID 12011084
Journal J Biol Chem
Year 2002
Volume 277
Pages 28080-7
Authors Wu N, Pai EF
Title Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylase.
Related PDB
Related UniProtKB
[31]
Resource
Comments
Medline ID
PubMed ID 12054799
Journal J Mol Biol
Year 2002
Volume 318
Pages 1019-29
Authors Harris P, Poulsen JC, Jensen KF, Larsen S
Title Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase.
Related PDB 1l2u
Related UniProtKB
[32]
Resource
Comments
Medline ID
PubMed ID 12667491
Journal Arch Biochem Biophys
Year 2003
Volume 412
Pages 267-71
Authors Smiley JA, DelFraino BJ, Simpson BA
Title Hydrogen isotope tracing in the reaction of orotidine-5'-monophosphate decarboxylase.
Related PDB
Related UniProtKB

Comments

Created Updated
2004-04-04 2009-02-26