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References
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[1]
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Resource
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Comments
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Medline ID
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PubMed ID
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3006670
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Journal
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Biochem J
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Year
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1986
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Volume
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233
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Pages
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493-7
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Authors
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Kim HS, Minard P, Legoy MD, Thomas D
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Title
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Inactivation of 3 alpha-hydroxysteroid dehydrogenase by superoxide radicals. Modification of histidine and cysteine residues causes the conformational change.
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Related PDB
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Related UniProtKB
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[2]
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Resource
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Comments
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Medline ID
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PubMed ID
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1793046
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Journal
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Agents Actions
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Year
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1991
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Volume
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34
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Pages
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289-93
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Authors
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Pawlowski J, Huizinga M, Penning TM
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Title
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Isolation and partial characterization of a full-length cDNA clone for 3 alpha-hydroxysteroid dehydrogenase: a potential target enzyme for nonsteroidal anti-inflammatory drugs.
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Related PDB
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Related UniProtKB
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[3]
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Resource
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Comments
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Medline ID
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PubMed ID
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1747374
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Journal
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Biochemistry
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Year
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1991
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Volume
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30
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Pages
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11553-60
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Authors
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Askonas LJ, Penning TM
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Title
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Development of affinity labeling agents based on nonsteroidal anti-inflammatory drugs: labeling of the nonsteroidal anti-inflammatory drug binding site of 3 alpha-hydroxysteroid dehydrogenase.
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Related PDB
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Related UniProtKB
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[4]
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Resource
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Comments
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Medline ID
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PubMed ID
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1788860
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Journal
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Steroids
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Year
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1991
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Volume
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56
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Pages
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420-7
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Authors
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Penning TM, Thronton R, Ricigliano JW
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Title
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Clues to the development of mechanism-based inactivators of 3 alpha-hydroxysteroid dehydrogenase: comparison of steroidal and nonsteroidal Michael acceptors and epoxides.
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Related PDB
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Related UniProtKB
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[5]
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Resource
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Comments
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Medline ID
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PubMed ID
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7945717
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Journal
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Farmaco
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Year
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1994
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Volume
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49
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Pages
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505-7
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Authors
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Plescia S, Raffa D, Daidone G, Schillaci D, Maggio B
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Title
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3 alpha-hydroxysteroid dehydrogenase inhibitory activity of some N(3)-(1-R-4-carboxypyrazol-5-yl)-1,2,3-benzotriazin-4(3H)-one and quinazolin-4(3H)-one acids.
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Related PDB
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Related UniProtKB
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[6]
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Resource
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Comments
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Medline ID
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PubMed ID
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8175784
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Journal
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J Biol Chem
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Year
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1994
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Volume
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269
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Pages
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13502-10
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Authors
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Pawlowski JE, Penning TM
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Title
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Overexpression and mutagenesis of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis.
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Related PDB
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Related UniProtKB
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[7]
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Resource
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Comments
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X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS)
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Medline ID
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94195773
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PubMed ID
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8146147
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Journal
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Proc Natl Acad Sci U S A
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Year
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1994
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Volume
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91
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Pages
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2517-21
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Authors
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Hoog SS, Pawlowski JE, Alzari PM, Penning TM, Lewis M
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Title
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Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily.
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Related PDB
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1ral
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Related UniProtKB
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P23457
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[8]
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Resource
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Comments
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Medline ID
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PubMed ID
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7676484
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Journal
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Steroids
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Year
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1995
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Volume
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60
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Pages
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491-6
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Authors
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Hu Y, Sherwin PF, Covey DF
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Title
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Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-15-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer.
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Related PDB
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Related UniProtKB
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[9]
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Resource
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Comments
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X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS)
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Medline ID
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96346063
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PubMed ID
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8718859
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Journal
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Biochemistry
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Year
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1996
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Volume
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35
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Pages
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10702-11
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Authors
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Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M
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Title
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Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.
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Related PDB
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1lwi
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Related UniProtKB
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P23457
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[10]
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Resource
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Comments
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Medline ID
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PubMed ID
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8943801
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Journal
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J Endocrinol
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Year
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1996
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Volume
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150 Suppl
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Pages
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S175-87
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Authors
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Penning TM
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Title
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3 alpha-hydroxysteroid dehydrogenase: three dimensional structure and gene regulation.
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Related PDB
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Related UniProtKB
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[11]
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Resource
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Comments
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Medline ID
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PubMed ID
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8883217
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Journal
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Steroids
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Year
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1996
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Volume
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61
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Pages
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508-23
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Authors
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Penning TM, Pawlowski JE, Schlegel BP, Jez JM, Lin HK, Hoog SS, Bennett MJ, Lewis M
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Title
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Mammalian 3 alpha-hydroxysteroid dehydrogenases.
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Related PDB
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Related UniProtKB
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[12]
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Resource
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Comments
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Medline ID
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PubMed ID
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9059665
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Journal
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Adv Exp Med Biol
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Year
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1997
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Volume
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414
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Pages
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579-600
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Authors
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Jez JM, Flynn TG, Penning TM
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Title
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A nomenclature system for the aldo-keto reductase superfamily.
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Related PDB
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Related UniProtKB
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[13]
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Resource
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Comments
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Medline ID
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PubMed ID
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9059653
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Journal
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Adv Exp Med Biol
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Year
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1997
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Volume
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414
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Pages
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475-90
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Authors
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Penning TM
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Title
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Hydroxysteroid dehydrogenases. New drug targets of the aldo-keto reductase superfamily.
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Related PDB
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Related UniProtKB
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[14]
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Resource
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Comments
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Medline ID
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PubMed ID
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9029723
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Journal
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Steroids
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Year
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1997
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Volume
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62
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Pages
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101-11
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Authors
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Penning TM, Bennett MJ, Smith-Hoog S, Schlegel BP, Jez JM, Lewis M
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Title
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Structure and function of 3 alpha-hydroxysteroid dehydrogenase.
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Related PDB
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Related UniProtKB
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[15]
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Resource
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Comments
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X-ray crystallography
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Medline ID
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PubMed ID
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9261071
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Journal
|
Structure
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Year
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1997
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Volume
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5
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Pages
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799-812
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Authors
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Bennett MJ, Albert RH, Jez JM, Ma H, Penning TM, Lewis M
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Title
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Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
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Related PDB
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1afs
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Related UniProtKB
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[16]
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Resource
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Comments
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Medline ID
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PubMed ID
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9657682
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Journal
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Biochemistry
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Year
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1998
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Volume
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37
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Pages
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9695-703
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Authors
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Jez JM, Penning TM
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Title
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Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase.
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Related PDB
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Related UniProtKB
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[17]
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Resource
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Comments
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Medline ID
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PubMed ID
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9692994
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Journal
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Biochemistry
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Year
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1998
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Volume
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37
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Pages
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11003-11
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Authors
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Schlegel BP, Ratnam K, Penning TM
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Title
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Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine.
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Related PDB
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Related UniProtKB
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[18]
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Resource
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Comments
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Medline ID
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PubMed ID
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10549852
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Journal
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Biol Pharm Bull
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Year
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1999
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Volume
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22
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Pages
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1038-46
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Authors
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Yamano S, Ichinose F, Todaka T, Toki S
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Title
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Purification and characterization of two major forms of naloxone reductase from rabbit liver cytosol, new members of aldo-keto reductase superfamily.
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Related PDB
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Related UniProtKB
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[19]
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Resource
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Comments
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Medline ID
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PubMed ID
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10418995
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Journal
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J Steroid Biochem Mol Biol
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Year
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1999
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Volume
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69
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Pages
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211-25
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Authors
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Penning TM
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Title
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Molecular determinants of steroid recognition and catalysis in aldo-keto reductases. Lessons from 3alpha-hydroxysteroid dehydrogenase.
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Related PDB
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Related UniProtKB
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[20]
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Resource
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Comments
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Medline ID
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PubMed ID
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10500147
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Journal
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Proc Natl Acad Sci U S A
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Year
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1999
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Volume
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96
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Pages
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11161-6
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Authors
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Ma H, Penning TM
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Title
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Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins.
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Related PDB
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Related UniProtKB
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[21]
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Resource
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Comments
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Medline ID
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PubMed ID
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10998348
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Journal
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Biochem J
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Year
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2000
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Volume
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351
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Pages
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67-77
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Authors
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Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K
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Title
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Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.
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Related PDB
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Related UniProtKB
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[22]
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Resource
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Comments
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Medline ID
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PubMed ID
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10876166
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Journal
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J Biochem (Tokyo)
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Year
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2000
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Volume
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128
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Pages
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121-8
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Authors
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Yamamoto T, Nozaki A, Shintani S, Ishikura S, Katagiri Y, Hara A
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Title
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Structure-specific effects of thyroxine analogs on human liver 3 alpha-hydroxysteroid dehydrogenase.
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Related PDB
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Related UniProtKB
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[23]
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Resource
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Comments
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Medline ID
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PubMed ID
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11306084
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Journal
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Chem Biol Interact
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Year
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2001
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Volume
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130-132
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Pages
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659-71
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Authors
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Penning TM, Ma H, Jez JM
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Title
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Engineering steroid hormone specificity into aldo-keto reductases.
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Related PDB
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Related UniProtKB
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[24]
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Resource
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Comments
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Medline ID
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PubMed ID
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11165022
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Journal
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Mol Cell Endocrinol
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Year
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2001
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Volume
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171
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Pages
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137-49
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Authors
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Penning TM, Burczynski ME, Jez JM, Lin HK, Ma H, Moore M, Ratnam K, Palackal N
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Title
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Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).
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Related PDB
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Related UniProtKB
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[25]
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Resource
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Comments
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Medline ID
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PubMed ID
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12943710
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Journal
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J Steroid Biochem Mol Biol
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Year
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2003
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Volume
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85
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Pages
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247-55
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Authors
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Penning TM, Jin Y, Heredia VV, Lewis M
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Title
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Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms.
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Related PDB
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Related UniProtKB
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